Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 9, Issue 4, 2011

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In 2011, genetic privacy bills were introduced in two US states proposing that genetic information and material are an individual's exclusive property. Using the bills as a catalyst for broader discussion, the author introduces several themes. On a primary level, the scientific, medical, and broader community should be cognizant of the bills as they may be precursors to new legislation with potential future impact on genomi Read More

Proteomics, the study of entire compendium of proteins encoded by a genome, is now established as a leading technological platform for numerous areas of clinical research in personalized medicine: understanding of disease pathogenesis, detection of disease specific biomarkers and identification of novel drug and vaccine targets, to name a few. The successful integration of nanotechnology with proteomics has introd Read More

A properly validated biological marker (biomarker) would offer undeniable value as a prognostic or diagnostic indicator of a disorder and/or its response to a therapeutic intervention. However, upon their discovery, a biomarker candidate must traverse a rigorous and exhaustive testing protocol aimed to challenge the validity of its proposed application. This validation trajectory establishes both the quality of a biomarker' Read More

Pharmacogenomics is a field with origins in the study of monogenic variations in drug metabolism in the 1950s. Perhaps because of these historical underpinnings, there has been an intensive investigation of ‘hepatic pharmacogenes’ such as CYP450s and liver drug metabolism using pharmacogenomics approaches over the past five decades. Surprisingly, kidney pathophysiology, attendant diseases and treatment out Read More

In pharmacogenomics studies, the analysis of gene-gene interactions increasingly plays a crucial role in characterizing a phenotypic trait that involves complex pharmacological mechanisms. Genetic association studies using individual genes may overlook the significant associations which can only be identified when the combinations of multiple genomic loci are employed. Indeed, by employing the candidate-gene approac Read More

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