Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 8, Issue 3, 2010

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Existing treatments for depression usually take several weeks to achieve their antidepressant effects, and a significant number of patients do not have adequate improvement or are treatment refractory even after long-term drug administration. Moreover, the increased risk of suicide is a serious public health concern that can occur particularly during the initial stages of antidepressant pharmacotherapy. Thus, there is an u Read More

After the completion of the human genome sequence, international efforts have been directed to the characterization of the genomes of human-associated resident microbes. The Human Microbiome Project was launched in 2007 with the aim of sequencing the resident microbiota from different sites of the human body. In this paper, we introduce the Human Microbiome Project, the role of the human microbiome in healt Read More

There have been a number of notable strides in Hungary in the field of population pharmacogenomics. This paper aims to summarize and share the recent experiences in population genomics and personalized medicine in Hungary with leaders of the Genomic National Technology Platform. The present day Hungary differs from other populations in the region as Hungary was established some 1100 years ago, with founders o Read More

The high-throughput ‘omics’ technologies and especially metabolomics can play a major role in advancing the field of personalized medicine and associated fields like nutrition science. Current nutrition research is not mechanism driven making it difficult to fully understand (or forecast) the effects of diet and nutritional interventions. The omics biotechnology platforms can offer a more complete understanding of the comple Read More

While the role of accumulations of mutations has been historically emphasized in the etiology of human cancers, converging evidence strongly implicates contributory epigenetic mechanisms as well. Recently, there have been accumulating observations on the role which epigenetics plays in the regulation of ABCB1 drug transporter expression and its ability to contribute to cancer incidence and multi-drug resistance (MDR) to Read More

It is well established that major psychosis (schizophrenia and bipolar disorder) has a strong hereditary basis. However, no unequivocal genetic mutation or polymorphism underlying these disorders has been identified thus far. This paper discusses the role of epigenetics (heritable changes in gene expression not involving changes in DNA sequence) in the pathogenesis of the major psychoses. Importantly, epigenetics offers a c Read More