Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 8, Issue 2, 2010

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Sepsis is one of the most complex human diseases that continue to be associated with high mortality rates and substantial medical costs. It is an infection-induced, complex traits systemic syndrome that engages most of the body's systems and organs. Whereas several etiologic agents can elicit sepsis, disease susceptibility, severity and therapeutic outcomes are modulated by a complex interaction of numerous environmen Read More

There has been a fundamental shift in biopharmaceutical research from a linear, systematic investigation to a more whole organism, systems-oriented analysis program. The impetus behind this change is an acknowledgment that the current novel target and drug discovery model was flawed due in part to an overly simplified view of disease biology, i.e., a unidirectional path from one gene to one protein to one mechan Read More

The objective of this study was to evaluate hospital directors' (study A) and community pharmacists' (study B) attitudes towards pharmacogenomics research and DNA banks in Japan. This is significant because pharmacotherapy is offered by both community pharmacies and hospitals in Japan. A total of 943 directors of all Japanese national, municipal and university hospitals were chosen for the study A. For the study B, 905 com Read More

Antiplatelet therapy with aspirin and clopidogrel, aimed to inhibit platelet function and reactivity, is the recommended standard of care for reducing the occurrence of cardiovascular events in patients with acute coronary syndromes undergoing percutaneous coronary intervention with stent implantation. However, major adverse cardiovascular events including the severe complication of stent thrombosis occur in patients taki Read More

Pharmacogenomics, applied as an aspect of molecular autopsy, might become an integral part of forensic medicine in the near future. Pharmacogenomics is the study of the relationship between an individual's genetic/genomic information and the disposition/response to medications. As a result, pharmacogenomics may provide a deeper mechanistic insight necessary for forensic pathologists to fully unde Read More

There have been many studies of phase-I drug metabolism (e.g., CYP450s) in personalized medicine research. By contrast, functional genetic variation in the phase-II detoxification pathways is relatively less appreciated. UDP-glucuronosyltransferases (UGTs) comprise a group of catabolic enzymes involved in the detoxification and excretion of drugs. This family glucuronidates many xenobiotic and endogenous substances i Read More