Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 15, Issue 1, 2017

Background: Cardiovascular diseases are the leading causes of mortality and hospitalizations especially in elderly patients, whose therapeutic management is particularly challenging due to the lack of specific recommendations, particularly in old patients with multiple comorbidities and disability. The ageing process is highly heterogeneous with several possible phenotypes ranging from healthy ageing to frailty. While in h Read More

Background: In the last decades aging of population is becoming even more prevalent, with consequent increasing requirement in health assistance and services. Physical and social environments can affect health directly, or through barriers or incentives conditioning opportunities, decisions and behavior. Moreover, the relationship with environment varies according to several personal characteristics including famil Read More

Background: Cardiovascular side effects occur rarely after iodinated contrast media administration and no real data can be found in literature. The presence of cardiovascular risk factors increases the incidence of these adverse reactions. Objective: Aim of the study was the analysis of the cardiovascular side effects due to use of intra-venous iodinated contrast media in diagnostic imaging. Methods: A MEDLINE and Pubmed Read More

Background: Cardiovascular disease is the leading cause of morbidity and mortality worldwide in developed countries, and its social and economic burden is expected to increase dramatically over the next decades. Despite significative improvement in the pharmacological treatment, and the huge advances in prevention, the quest for new molecular targets and for novel, more efficient and personalized therapies is still a priori Read More

Background: Cardiovascular diseases (CVD) are the leading causes of death worldwide. Objective: The aim of this review is to evaluate several non-pharmacological approaches to fight the development of CVD. Results: Various strategies have been used to induce lifestyle changes in order to reduce CVD development. In recent years, accumulating evidence has suggested that plant-foods polyphenols, due to their biological pr Read More

Background: The definition of the individual's molecular profile will promote a specific and tailored therapeutic approach for each patient. This method has found application in specific drug decision-making in the oncology field, but not for cardiovascular pathologies. Objective: In this review, we describe some relevant molecular features of the cardiovascular disease in the context of personalized medicine, discussing Read More

Background: Variability in response to pharmacological treatment is one of the most important issues in the clinical practice at first exclusively attributed to clinical and demographic factors such as age, sex, nutritional status, alcohol abuse, smoking, presence of comorbidities and polypharmacy. Nowadays, it is well known that also genetic factors can modify the outcomes of pharmacological treatments. Polymorph Read More