Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 13, Issue 2, 2015

Background: Obsessive-compulsive disorder (OCD) is a common mental illness and a ubiquitous cause of disability. Approximately half of the patients with OCD only partially respond or do not respond at all to current ways of treatment. Even patients responding to treatment usually need high doses of medication and/or intense psychotherapy for a long time. It is obvious that therapeutic approaches to OCD need improvin Read More

Background: There is a plethora of studies indicating temporal relationship between utilization of Omega-3-fatty acids and amelioration of emotional distress including depression. Some studies have also emerged to indicate the role of fish oil (FO) as adjunct therapy for depressive symptoms in clinical literature. In order for such view to have heuristic value, pre-clinical behavioral paradigms are needed to scrutinize Read More

Background: The survival of all biological systems depends on a series of complex pathways of maintenance and repair systems, which are the crucial components of the homeodynamic space of an individual. A progressive failure of maintenance and the consequent shrinkage of the homeodynamic space are the fundamental basis of ageing, age-related diseases and eventual death. Mechanisms: Although longevity a Read More

Background: Mitochondria are critically important in providing cellular energy ATP. They also play important roles in anti-oxidant defense, fat oxidation, intermediary metabolism and cell death processes. It is well-established that mitochondrial functions are suppressed through nitroxidative stress when living cells or organisms are exposed to potentially toxic agents including alcohol, high fat diets, smoking and c Read More

Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been described. Many efforts have been made to explore the mechanisms for the neuro-protective properties of natural compounds. This rev Read More

Acute myeloid leukemia (AML) is the most common leukemia diagnosed in adults and curative treatments remain currently a great challenge. AML occur in about 60% of patients over 60 years with unsatisfactory survival results, which have not improved significantly over the last two decades, in spite of improved supportive care. Global genomic instability is the hallmark of the disease, leading to chromosomal/molecular alterat Read More