Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 12, Issue 1, 2014

With growing information on antiretroviral drug pharmacogenetics, several studies have been conducted in African countries. One unique strand of knowledge that is currently emerging is the use of dried plasma spot devices in rural communities in Africa with a view to individualizying drugs employed against HIV infection. The results are encouraging as a relatively inexpensive test could inform on the probability of adverse r Read More

For more than 60 years, genetic variation had been recognized as an important determinant of inter-individual variability in drug efficacy and drug safety. Pharmacogenomics, studying the variations of DNA sequence and gene expression related to drug responses, is the whole genome application of pharmacogenetics. The aim of PGt/PGx is to elucidate functionally relevant genomic determinants for drug metabolism, tr Read More

Pharmacogenomics as a science aims at individualizing the treatment based on the genetic makeup, to mitigate the chances of adverse drug events and/or to maximize the efficacy in a sub-population. Pharmacometrics is the science of quantifying disease, drug and trial characteristics with the goal to influence key drug development, regulatory and therapeutic decisions. Pharmacometric analysis as a tool has revolution Read More

Personalized medicine will play an important role in the treatment of infectious diseases. Molecular microbiology diagnostics have the potential to identify pathogens with great accuracy and rapidity. The speed of identification is particularly crucial to effective clinical management of many infections. An important complement to precision diagnostic techniques is moving towards point-of-care application, to avoid the costly Read More

The inter-patient differences in drug response is documented to be attributable to heritable genetic variations in the nucleotide sequence of drug-metabolizing enzymes. The identification of variant allele frequencies in specific ethnic groups is important to individualize drug dosing and improve therapeutics. This study aimed to detect single-nucleotide polymorphism (SNP) in CYP3A4 and the homozygous deletion (0/0) of GSTM1 Read More

Concerns about genetic discrimination (GD) have been reported since the 1980s. The potential chilling effects of GD both in the clinical and research settings have prompted the adoption of a myriad of laws and moratoria on access to genetic data in Europe and the United States. Recent studies in Canada, Australia and Germany concerning patients and family members at-risk for Huntington’s disease have raised concern Read More