Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 10, Issue 1, 2012

Full Text Available.

Full Text Available.

Traditional Chinese Medicine (TCM) is a range of medical practices and health interventions used in China for more than four millennia. While TCM continues to impact healthcare and population health in the Asia-Pacific, it has also received growing attention globally over the last decade. This paper argues that we are currently at a critical junction to accelerate both TCM and its evidence base with the availability of genomics a Read More

Some empirical studies and recent developments in pharmacokinetic theory suggest that statistical randomeffects linear models are valuable tools that allow describing simultaneously patient populations as a whole and patients as individuals. This remarkable characteristic indicates that these models may be useful in the development of personalized medicine, which aims at finding treatment regimes that are appropriate for p Read More

Pharmacogenomics has long attempted to identify genome-drug interactions and environmental exposures as guideposts for personalized medicine. However, non-drug related environmental factors, too, can interact with the host genome and potentially cause confounding in explaining drug-genome interactions. One such environmental factor that has been bracketed out in the past is the ambient temperatur Read More

The health burden resulting from parasitic and infectious diseases such as HIV/AIDS, tuberculosis and malaria, requires that available medication and limited healthcare resources be used optimally. However, due to co-morbidities, patients are often exposed to many drugs concurrently. Most of these drugs are metabolised by similar enzymes which are polymorphic, thus, drug-drug interactions are a constant problem. Quantit Read More

Janus Kinases (JAKs) and Signal Transducer and Activator of Transcription proteins (STATs) are central mediators of cytokine and growth factor signaling pathways that are constitutively active in several cancers and play an important role in cancer progression. Glioblastoma multiforme (GBM; WHO grade IV) is the most commonly occurring brain tumor with very poor prognosis, limited options of treatment and a median Read More

The field of personalized medicine is currently broadening in scope in at least three crucial dimensions. First, while genetics/genomics individual variability is an important aspect of personalized medicine, it is clear that environmental, nutritional, lifestyle and social risk factors play a crucial role for suboptimal therapeutics or disease susceptibility. Second, personalized medicine can inform not only drug therapy but also prev Read More

In order for the promise of personalised medicine to be realized, a thorough understanding and description of the genetic variants that affect drugs side effects and therapeutic response must be realized for all populations in the world. Although certain populations can have the patterns of genetic variation imputed or extrapolated from other related populations, African populations are too heterogeneous to extrapolate gen Read More

The reader will find below the list of expert reviewers who dedicated their time and expertise to the peer-review process of the Journal over the past year. Rigorous, objective and timely peer-review is crucial to sustain the high publication standards of the CPPM. I am glad to take this opportunity to thank the CPPM editors and the reviewers for their availability, promptness and valuable comments that support the edito Read More