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- Volume 20, Issue 30, 2014
Current Pharmaceutical Design - Volume 20, Issue 30, 2014
Volume 20, Issue 30, 2014
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Editorial (Thematic Issues: Basic and Clinical Aspects of Melatonin in the Gastrointestinal Tract. New Advancements and Future Perspectives)
Authors: Thomas Brzozowski and Jolanta JaworekThis special issue of Current Pharmaceutical Design is intended to provide an update on the role of melatonin, originally discovered as the major secretory product of the pineal gland, in the treatment of upper and lower of the gastrointestinal (GI) tract disorders. It has become evident that melatonin is a widely-produced and ubiquitously-distributed molecule with multiple critical functions in all organs and in all organisms bu Read More
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Melatonin in the Biliary Tract and Liver: Health Implications
Melatonin is a widely-produced and ubiquitously-distributed molecule with multiple critical functions in all organs and organisms. These functions are mediated by both receptor-mediated and receptor-independent actions of the indole. This survey reviews the reports documenting the presence and function of melatonin in the hepatobiliary system. The published data document the exceptionally high concentrations of Read More
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Detection of Melatonin Production from the Intestinal Epithelium Using Electrochemical Methods
Authors: Paul P. Bertrand, Kate E. Polglaze, Rebecca L. Bertrand, Shaun L. Sandow and Maria J. PozoThe role of melatonin in the gastrointestinal (GI) tract had previously been limited to its well-described anti-oxidant properties. Recent studies have, however, expanded the role of melatonin in the intestine, showing that it acts as a hormone with local paracrine actions to modulate GI function and the release of other hormones. The GI epithelium produces melatonin from the active precursor serotonin, which is thought to com Read More
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Mechanisms of Esophageal Protection, Gastroprotection and Ulcer Healing by Melatonin. Implications for the Therapeutic use of Melatonin in Gastroesophageal Reflux Disease (GERD) and Peptic Ulcer Disease
Melatonin is a potent reactive oxygen metabolite scavenger and antioxidant that has been shown to influence many physiological functions of the gastrointestinal (GI) tract including secretion, motility, digestion and absorption of nutrients. The role of melatonin in gastroduodenal defense and ulcer healing has been the subject of recent investigations. Melatonin produced in the GI mucosa plays an important role in protection a Read More
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Melatonin, Autophagy and Intestinal Bowel Disease
Authors: Elena Talero, Sofia Garcia-Maurino and Virginia MotilvaThe intestinal epithelium forms a barrier against the intestinal contents and the wider environment, allowing entry of selected molecules for nutrition and programming of the mucosal immune system, but excluding toxins and most microorganisms. Many receptors and signalling pathways are coupled and implicated in the epithelial control and significant advances have been achieved in the understanding of the p Read More
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Protective Role of Melatonin in Liver Damage
Authors: Cezary Chojnacki, Ewa Walecka-Kapica, Marek Romanowski, Jan Chojnacki and Grazyna KlupinskaThe liver plays a key role in the detoxification of numerous molecules which results in the formation of an excessive number of toxic reactive oxygen species. This results in oxidative damage to the hepatocytes, which when severe, compromises the function of this critical organ. A variety of antioxidants protect the liver from free radical-mediated damage, one of the best of which is melatonin. Clinical studies have confirm Read More
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The Role of Melatonin in Pancreatic Protection: Could Melatonin be Used in the Treatment of Acute Pancreatitis?
Acute pancreatitis is a disease, which could be manifested as either a mild edematous form or a more severe necrotizing pancreatitis which has a poor prognosis. The etiology and pathogenesis of this ailment is not completely clear. Melatonin is an indoleamine which is produced from L-tryptophan in the pineal gland and in the other tissue including gastrointestinal tract. Both melatonin and its precursor have been demo Read More
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Melatonin and Glucose Metabolism: Clinical Relevance
Authors: Lardone P.J., Alvarez-Sanchez Sanchez N., Guerrero J.M. and Carrillo-Vico A.The role of melatonin in glucose homeostasis is an active area of investigation. There is a growing body of evidence suggesting a link between disturbances in melatonin production and impaired insulin, glucose, lipid metabolism, and antioxidant capacity. Furthermore, melatonin has been found to influence insulin secretion both in vivo and in vitro, and night-time melatonin levels are related to night-time insulin concentrati Read More
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Editorial: Targeting Neuregulin1 and HER Receptor Tyrosine Kinases for Therapy of Breast Cancer and Heart Failure
By Xinhua YanThe Neuregulin1 proteins and HER receptor tyrosine kinases are pivotal for function and disease development of multiple organ systems, including breast cancer and the heart [1, 2]. The HER2 receptor is mutated or overexpressed in about 20-30% of metastatic breast cancers [3]. Therefore, it is a major drug target of breast cancer therapy. Trastuzumab, a monoclonal antibody that directly binds and blocks the HER2 receptor, i Read More
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Neuregulin Signaling in Pieces—Evolution of the Gene Family
More LessParacrine and juxtacrine signaling via proteins expressed on the cell surface are an integral part of metazoan biology. More than one-half billion years ago epidermal growth factor (EGF) and its cognate receptor formed a functional binding partnership, which has been conserved through evolution in essentially all eubilaterate members of the animal kingdom. Early chordates spawned offspring of these seminal genes to b Read More
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Heregulin in Breast Cancer: Old Story, New Paradigm
Authors: Ashwani Khurana, Anatilde Gonzalez-Guerrico and Ruth LupuHeregulin (HRG), a combinatorial ligand for the epidermal growth factor receptor family, is expressed in about 30% of breast cancer tumors. HRG induces tumorigenicity and metastasis of breast cancer cells and promotes hormone-independent growth [1]. Although HRG has been studied mostly in the context of the HRG receptor family, accumulating evidence suggests that HRG plays distinctive and causative roles in brea Read More
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Breast Cancer Biomarkers: Risk Assessment, Diagnosis, Prognosis, Prediction of Treatment Efficacy and Toxicity, and Recurrence
Authors: Amy M. Braden, Rachel V. Stankowski, Jessica M. Engel and Adedayo A. OnitiloBreast cancer is the most common cancer amongst women in the United States and around the world. Although widespread use of adjuvant chemotherapeutic and hormonal agents has improved mortality from breast cancer, it remains challenging to determine on an individual basis who will benefit from such treatments and who will be likely to encounter toxicities. With the rising costs of healthcare and the introduction of Read More
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Cardiovascular Effects of Neuregulin-1/ErbB Signaling: Role in Vascular Signaling and Angiogenesis
Authors: Nadia Hedhli, April Kalinowski and Kerry S. RussellThe NRG/erbB pathway has emerged as an important therapeutic target for cancer growth as well as cardiac related diseases. This discovery stems back to findings showing that overexpression of erbB2 receptors increases the metastatic potential of breast cancer in patients. Blocking this receptor using a monoclonal antibody (trastuzumab) inhibits tumor growth and offers significantly improved outcomes. However, excite Read More
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The Developing Role of Neuregulin1 In Cardiac Regenerative Stem Cell Therapy
Authors: Christopher P. Blomberg, Juyong Lee and James P. MorganMyocardial infarction, heart failure, and chronic ischemic heart disease account for the majority of the cardiovascular burden. The current treatment strategies focus on limiting the progression of disease and preserving cardiac myocardium. The goal of stem cell therapy, on the other hand, is to reverse or replace damaged cardiac tissue. Over the past two decades many studies have been conducted to understand ste Read More
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Anti-HER2 Cancer Therapy and Cardiotoxicity
Authors: Tania Babar, Christopher Blomberg, Eileen Hoffner and Xinhua YanA significant milestone in the treatment of breast cancer is the identification of the HER2 receptor as a drug target for cancer therapies. Trastuzumab (Herceptin), a monoclonal antibody that blocks the HER2 receptor, is among the first of such drugs approved by the US Food and Drug Administration for targeted cancer therapy. Clinical studies have shown that Trastuzumab significantly improves the overall survival of br Read More
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Tumor Dormancy and the Angiogenic Switch: Possible Implications of Bone Marrow- Derived Cells
Authors: Yuval Shaked, Sandra McAllister, Ofer Fainaru and Nava AlmogAlthough escape from tumor dormancy has long been recognized as an important problem in the treatment of cancer, the molecular and cellular regulators underlying this transition remain poorly understood. The inability of the cancer cells to induce a complete and successful process of angiogenesis can result in tumor dormancy. In this case, the acquisition of sufficient angiogenic potential will result in the escape from in Read More
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Mathematical Modeling of Tumor Growth and Treatment
Authors: Heiko Enderling and Mark A.J. ChaplainUsing mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research. An increasing number of mathematical, physical, computational and engineering techniques have been applied to various aspects of tumor growth, with the ultimate goal of understanding the response of the cancer p Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
- Issue 42
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- Issue 40
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- Issue 38
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- Issue 31
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- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 18
- Issue 24
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- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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