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- Volume 20, Issue 29, 2014
Current Pharmaceutical Design - Volume 20, Issue 29, 2014
Volume 20, Issue 29, 2014
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Editorial (Thematic Issue: Crosstalk Between the Nervous and the Immune Systems in Health and Sickness)
More LessToday it is recognized that the regulatory systems namely nervous, endocrine and immune systems, do not function independently but are intimately linked, constituting a psychoneuroimmunoendocrine system. The communication between these physiological systems, is the basis of the maintenance of homeostasis and therefore of health. Each of these homeostatic systems is complex and more so, the interactions betw Read More
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The Effect of Psychological Stress and Social Isolation on Neuroimmunoendocrine Communication
Authors: Julia Cruces, Cesar Venero, Inmaculada Pereda-Peeez and Monica De la FuenteThe adaptive response to physical or psychological challenges or threats involves the modulation of the three regulatory systems: the nervous, endocrine and immune systems. Correct communication between these systems is required to maintain a homeostatic balance, and to guarantee the health and survival of the individual. While the stress response is essential for survival, failure to cope with a stress can impair the fu Read More
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Neuroimmune Interactions and Psychologycal Stress Induced by Cohabitation with a Sick Partner: A Review
Authors: Joao Palermo-Neto and Glaucie Jussilane AlvesThis study reviews the neuroimmunological consequences elicited in mice from long-term cohabitation with tumor-bearing conspecifics. Two types of experiments were performed; one used Swiss female mice and Ehrlich tumor cells, and the other used C57Bl/6 female mice and B16F10 melanoma cells. The female Swiss mice and the C57Bl/6 mice were divided into two groups, i.e., control and experimental. One mouse i Read More
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Chronobiology of the Neuroimmunoendocrine System and Aging
Authors: Ianire Mate, Juan Antonio Madrid and Monica De la FuenteThe health maintenance depends on the preservation of the homeostatic systems, such as nervous, endocrine and immune system, and a proper communication between them. In this regard, the circadian system, which promotes a better physiological system functions and thus well being, could be considered part of that homeostatic complex, since the neuroimmunoendocrine system possesses circadian patterns in most v Read More
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Increase of Oxidation and Inflammation in Nervous and Immune Systems with Aging and Anxiety
Authors: Carmen Vida, Eva M. Gonzalez and Monica De la FuenteAccording to the oxidation-inflammation theory of aging, chronic oxidative stress and inflammatory stress situations (with higher levels of oxidant and inflammatory compounds and lower antioxidant and anti-inflammatory defenses) are the basis of the agerelated impairment of organism functions, including those of the nervous and immune systems, as well as of the neuroimmune communication, which explains the alter Read More
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The Pivotal Role of Nitric Oxide: Effects on the Nervous and Immune Systems
Nitric oxide (NO) has an important role in physiological and pathological processes in general, and in particular plays a homeostatic role in the nervous and immune systems. The many different physiological functions of NO include those of a mediator of blood vessel dilation, neurotransmitter, neuromodulator and inductor of mitochondrial biogenesis. In addition, NO can transform into highly reactive and har Read More
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Physiology and Therapeutic Potential of the Thymic Peptide Thymulin
Thymulin is a thymic hormone exclusively produced by the epithelial cells of the thymus. After its discovery and initial characterization in the ‘70s, it was demonstrated that the production and secretion of thymulin are strongly influenced by the neuro-endocrine system. Conversely, a growing body of evidence, to be reviewed here, suggests that thymulin is a hypophysiotropic peptide. Additionally, a substantial body of informati Read More
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Role of the Endocannabinoid System in the Neuroendocrine Responses to Inflammation
Authors: Andrea De Laurentiis, Hugo A. Araujo and Valeria RettoriA few years ago the endocannabinoid system has been recognized as a major neuromodulatory system whose main functions are to exert and maintain the body homeostasis. Several different endocannabinoids are synthesized in a broad class of cell types, including those in the brain and the immune system; they bind to cannabinoid G-protein-coupled receptors, having profound effects on a variety of behavioral, neuroen Read More
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Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System
The central nervous system (CNS) innate immune response includes an arsenal of molecules and receptors expressed by professional phagocytes, glial cells and neurons that is involved in host defence and clearance of toxic and dangerous cell debris. However, any uncontrolled innate immune responses within the CNS are widely recognized as playing a major role in the development of autoimmune disorders and neurodegener Read More
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Crosstalk between Behavior and Immune System During the Prodromal Stages of Alzheimer’s Disease
Authors: Lydia Gimenez-Llort, Virginia Torres-Lista and Monica De la FuenteThe crosstalk in the functional interplay of the neuroimmune system is essential to ensure homeostasis preservation and health. Alzheimer’s disease (AD) can be understood in the context of aging of this neuroimmune communication. AD has an important genderdependent component and is benefitted by lifestyle strategies such as physical exercise, enriched environments and nutrition. Recently, the functional and redo Read More
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Physiologic Versus Diabetogenic Effects of Interleukin-1: A Question of Weight
Authors: Hugo O. Besedovsky and Adriana del ReyPleiotropic effects, great potency, and the capacity to induce its own production are distinguishing characteristics of IL-1. Among the multiple physiological effects of this cytokine, we emphasize here its role in supporting immune processes by stimulating most immune cells, and in re-setting glucose homeostasis. These aspects are complementary because stimulatory actions of IL-1 may be due to its capacity to increa Read More
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Inflammation, Infection and Preterm Birth
Preterm birth is the leading cause of perinatal morbidity and mortality. Pathological processes that have been linked with preterm birth infection and / or intrauterine inflammation are most frequently found associated with their induction. Studies in animal models and human research showed prior infections to the induction of labor, the anteriority of infection over labor induction, and the existence of a subclinical latency phase Read More
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Host Neuro- Immuno-Endocrine Responses In Periodontal Disease
Authors: Elisa Rettori, Andrea De Laurentiis, W. Les Dees, Axel Endruhn and Valeria RettoriPeriodontitis is a chronic inflammatory complex disease caused by microorganisms. It may be influenced by diverse systemic disorders, environmental, genetic and socio-psychological factors with the ability to alter the balance of the host neuro-immunoendocrine responses. It is characterized by the progressive destruction of the tooth supporting apparatus leading to tooth loss, with possible impact on general he Read More
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Neuroimmune Aspects of Sjogren’s Syndrome: Role of VIP/VPAC System in Immune and Salivary Gland Epithelial Cell Function
Sjogren’s syndrome (SS) is a chronic inflammatory disease characterized by salivary and lacrimal gland dysfunction although extraglandular manifestations are also found. Suitable study models and in vitro cell culture designs are used to approach SS pathogenic mechanisms. Cellular and molecular pathways involved in gland homeostasis loss and the autoimmune response are focused in the search of novel drug targets a Read More
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Neuroendocrine Stimulation of Mucosal Immune Cells in Inflammatory Bowel Disease
More LessCrohn’s disease and ulcerative colitis are the major inflammatory bowel diseases (IBD) in humans. With the incidence of increasing world-wide, it currently affects 4 million people in Europe and in the USA. It is an idiopathic, chronic relapsing intestinal disorder of complex pathogenesis. The etiology of both diseases remains unknown, but recent data suggest that they appear in genetically predisposed individuals, because of Read More
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Social Neuroeconomics: The Influence of Microbiota in Partner-Choice and Sociality
Authors: Montiel-Castro, Augusto J., Baez-Yanez, Mario G. and Pacheco-Lopez GustavoBy focusing on the studies of primate behaviour and human neuroscience, we describe how different neurological processes are the base of proximate aspects of social-decision making. We also review the fact that distinct aspects of animal behaviour are not under conscious or abstract control and that instead they may be regulated by adaptive ´rules of thumb´. In particular, by describing the microbiota- gut-brain axis Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
- Issue 42
- Issue 41
- Issue 40
- Issue 39
- Issue 38
- Issue 37
- Issue 36
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- Issue 31
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- Issue 29
- Issue 28
- Issue 27
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- Issue 25
- Issue 18
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- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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