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- Volume 17, Issue 20, 2011
Current Pharmaceutical Design - Volume 17, Issue 20, 2011
Volume 17, Issue 20, 2011
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Editorial [Hot Topic: Mitochondria as a Pharmacological Target: A Clue for Efficacy and a Reason for Toxicity (Executive Guest Editor: Nadezda Apostolova)]
More LessMitochondria have been in the focus of intense biomedical research over the last 10 years. The complex participation of these organelles in cellular pathophysiology arises from their versatile function which includes bioenergetics, ROS generation and redox balance, Ca2+ homeostasis maintainance, thermogenesis, essential anabolic pathways as well as active regulation of several cell survival/death pathways. Importan Read More
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Mitochondrial Dysfunction and Targeted Drugs: A Focus on Diabetes
Authors: Victor M Victor, Milagros Rocha, Celia Banuls, Lorena Bellod and Antonio Hernandez-MijaresDiabetes is a severe, heterogeneous, multifactorial, chronic disease. Diabetes and oxidative stress are related to continuous and acute overproduction of reactive oxygen species (ROS). These ROS are released principally from mitochondria, but also have other sources. Oxidative stress seems to play an important role in mitochondria-mediated disease processes, though the exact molecular mechanisms responsibl Read More
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Mitochondrial Drug Targets in Cell Death and Cancer
Authors: Gustavo Ferrin, Clara I. Linares and Jordi MuntaneMitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival. Since cancer cells have frequently disrupted different cell death pathways that promote their survival, mitochondria may be key organelles to promote cell death in cancer cells. The present review is focused on the different experimental and therapeutic cancer strategies addressed to ei Read More
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Mitochondrial Therapeutics for Cardioprotection
Authors: Raquel S. Carreira, Pamela Lee and Roberta A. GottliebMitochondria represent approximately one-third of the mass of the heart and play a critical role in maintaining cellular function- however, they are also a potent source of free radicals and pro-apoptotic factors. As such, maintaining mitochondrial homeostasis is essential to cell survival. As the dominant source of ATP, continuous quality control is mandatory to ensure their ongoing optimal function. Mitochondrial quality control i Read More
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Principles and Therapeutic Relevance for Targeting Mitochondria in Aging and Neurodegenerative Diseases
Aging is a physiologic state in which a progressive decline of organ functions may be accompanied by developing age-related diseases and neurodegenerative diseases. The causes of such conditions remain unknown, being probably related to a multifactor process. To date, the Free Radical and Mitochondrial theories seem to be the two most prominent that could explain both how and why aged people develop certai Read More
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Mitophagy and Disease: New Avenues for Pharmacological Intervention
Authors: Robert Taylor and Scott J. GoldmanThe process of intracellular macromolecular degradation known as macroautophagy has long been associated with the degradation of mitochondria. Recent studies have provided evidence that the process of mitochondria degradation via autophagy, now referred to as mitophagy, appears to be specifically targeted to mitochondria and highly regulated under both physiologic and pathologic conditions. This article pr Read More
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The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas' Disease
Trypanosoma cruzi is the causative agent of Chagas' disease, which affects some 8 - 10 million people in the Americas. The only two drugs approved for the etiological treatment of the disease in humans were launched more than 40 years ago and have serious drawbacks. In the present work, we revisit the unique characteristics of T. cruzi mitochondria and mitochondrial metabolism. The possibility of taking adva Read More
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New Insights in Drug-Induced Mitochondrial Toxicity
Authors: Sashi Nadanaciva and Yvonne WillDrug-induced mitochondrial toxicity is rapidly gaining recognition within the pharmaceutical industry as a contributor to compound attrition and post-market drug withdrawals. This article describes the mechanisms which lead to drug-induced mitochondrial toxicity, discusses high-throughput in vitro assays which are currently being used to identify mitochondrial dysfunction, and provides an overview on some of the drugs whi Read More
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Drug-induced Cardiac Mitochondrial Toxicity and Protection: From Doxorubicin to Carvedilol
Mitochondria have long been involved in several cellular processes beyond its role in energy production. The importance of this organelle for cardiac tissue homeostasis has been greatly investigated and its impairment can lead to cell death and consequent organ failure. Several compounds have been described in the literature as having direct effects on cardiac mitochondria which can provide a mechanistic expl Read More
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Mitochondrial Toxicity in HAART: An Overview of In Vitro Evidence
Authors: Nadezda Apostolova, Ana Blas-Garcia and Juan V. EspluguesThe combined antiretroviral therapeutic approach currently employed for the treatment of HIV infection, known as Highly Active Antiretroviral Therapy (HAART), has dramatically reduced AIDS-related morbidity and mortality. However, the adverse reactions associated with the long term use of this therapy have now become a major issue and researchers have focused on understanding the cellular mechanisms underlyin Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
- Issue 38
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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