Full text loading...
- ISSN: 1381-6128
- E-ISSN: 1873-4286
-
The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas' Disease
- Source: Current Pharmaceutical Design, Volume 17, Issue 20, Jul 2011, p. 2074 - 2099
-
- 01 Jul 2011
Abstract
Trypanosoma cruzi is the causative agent of Chagas' disease, which affects some 8 - 10 million people in the Americas. The only two drugs approved for the etiological treatment of the disease in humans were launched more than 40 years ago and have serious drawbacks. In the present work, we revisit the unique characteristics of T. cruzi mitochondria and mitochondrial metabolism. The possibility of taking advantage of these peculiarities to target new drugs against this parasite is also discussed.
© Bentham Science Publishers