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- Volume 17, Issue 1, 2011
Current Pharmaceutical Design - Volume 17, Issue 1, 2011
Volume 17, Issue 1, 2011
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Cytokines as Therapeutic Targets to Reduce Cardiovascular Risk in Chronic Inflammation
Authors: Ashley M. Miller and Iain B. McInnesPatients with chronic inflammatory diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus, psoriasis and Crohn's disease have an increased atherosclerotic risk which cannot be explained by traditional cardiovascular risk factors alone. Inflammatory pathways are implicated in this increased vascular risk. The involvement of cytokine-related signaling pathways in inflammatory diseases has prompted the devel Read More
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The Role of Coagulation in Chronic Inflammatory Disorders: A Jack of All Trades
Authors: Keren S. Borensztajn, Jan H. von der Thusen and C. Arnold SpekChronic inflammatory disorders constitute a heterogenous group of complex and multifactorial diseases, which are often associated with increased cardiovascular morbidity and mortality, independent of the established cardiovascular risk factors. In keeping with this observation, hypercoagulability is frequently observed in patients suffering from atherosclerosis, chronic obstructive pulmonary disease and rheumat Read More
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Chronic Inflammatory Disorders and Accelerated Atherosclerosis: Chronic Kidney Disease
Increasing evidence points to the fact that plasma HDL cholesterol levels do not always accurately predict HDL function including reverse cholesterol transport and modulation of inflammation. These functions appear to have evolved as part of our innate immune system. HDL is anti inflammatory in healthy individuals in the absence of systemic oxidative stress and inflammation. In those with chronic illnesses such as Read More
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Critical Determinants of Cardiovascular Risk in Rheumatoid Arthritis
Authors: R. J. Bisoendial, E. S.G. Stroes and P. P. TakRheumatoid arthritis (RA), a prototypical immune-mediated inflammatory disease, is characterized by increased cardiovascular morbidity and mortality, independent from the established cardiovascular risk factors. The chronic inflammatory state, a hallmark of RA, is considered to be a driving force for accelerated atherogenesis. Concurrent conditions that expedite the atherosclerotic process in RA involve endothelial dy Read More
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Oxidative Modification of Lipoproteins: Mechanisms, Role in Inflammation and Potential Clinical Applications in Cardiovascular Disease
Authors: Sotirios Tsimikas and Yury I. MillerAbnormalities of lipid metabolism often lead to pathologic lipid accumulation in the vessel wall, oxidative and chronic inflammatory sequelae and the formation of atherosclerotic lesions, ultimately leading to clinical events. Oxidation of lipoproteins, and in particular low density lipoprotein (LDL), is a seminal even that mediates many pro-atherogenic and pro-inflammatory pathways. Many in vivo mechanisms exist to oxidize Read More
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Pentraxins and Atherosclerosis: The Role of PTX3
Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxi Read More
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Mean Platelet Volume: A Link Between Thrombosis and Inflammation?
Authors: Armen Yuri Gasparyan, Lilit Ayvazyan, Dimitri P. Mikhailidis and George D. KitasPlatelet activation is a link in the pathophysiology of diseases prone to thrombosis and inflammation. Numerous platelet markers, including mean platelet volume (MPV), have been investigated in connection with both thrombosis and inflammation. This review considers MPV as a prognostic and therapeutic marker as well as the factors influencing its measurement. Established cardiovascular risk factors, such as smoking, hy Read More
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Omacetaxine as an Anticancer Therapeutic: What is Old is New Again
Authors: Meir Wetzler and David SegalOmacetaxine mepesuccinate was originally identified more than 35 years ago and initial studies in chronic myeloid leukemia (CML) showed promising activity. It has also been studied in other hematologic and solid tumors as both a single agent and in combination with other treatments. However, the introduction of imatinib and related tyrosine kinase inhibitors (TKIs) abated the clinical development of omacetaxine as a t Read More
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Self Assembling Polymers as Polymersomes for Drug Delivery
Authors: Jay Prakash Jain, Wubeante Yenet Ayen and Neeraj KumarPolymersomes are one of the most interesting and versatile architectures among various self assembled systems for drug delivery. The stability and ability to load both hydrophilic and hydrophobic molecules make them excellent candidates to use as drug delivery systems. They demand for certain physicochemical parameters; especially hydrophilic to hydrophobic block ratio of copolymer to form vesicular morphologies. Diff Read More
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Advances and Perspectives in Cell-Specific Aptamers
Authors: Wei Sun, Lupei Du and Minyong LiNucleic acid aptamers, generated by an in vitro selection procedure named SELEX (Systematic Evolution of Ligands by EXponential enrichment), have been popularly used in various biomedical implementations so far. An adaptation of the conventional SELEX practice to whole living cells was referred to as cell-SELEX, which is very promising in ample sophisticated analytical, therapeutic and diagnostic applications. The current Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
- Issue 38
- Issue 37
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- Issue 31
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- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
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- Issue 3
- Issue 2
- Issue 1
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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