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- Volume 15, Issue 22, 2009
Current Pharmaceutical Design - Volume 15, Issue 22, 2009
Volume 15, Issue 22, 2009
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Editorial [Hot Topic: Perspectives in Psychopharmacological Neuroimaging (Executive Editor: Paolo Fusar-Poli)]
More LessOver the past decade, psychiatry has grown in close contact with the advancements of clinical neurosciences. In particular, basic and clinical psychopharmacology has largely benefited from a large array of neuroimaging studies, which provided a direct way of investigating the pathophysiology of mental disorders in vivo. The structural cerebral abnormalities of gray and white matter underlying the clinical featur Read More
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The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? A Systematic Review
Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies Read More
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Mechanisms Underlying Psychosis and Antipsychotic Treatment Response in Schizophrenia: Insights from PET and SPECT Imaging
Authors: O. D. Howes, A. Egerton, V. Allan, P. McGuire, P. Stokes and S. KapurMolecular imaging studies have generated important in vivo insights into the etiology of schizophrenia and treatment response. This article first reviews the PET and SPECT evidence implicating dopaminergic dysfunction, especially presynaptic dysregulation, as a mechanism for psychosis. Second, it summarises the neurochemical imaging studies of antipsychotic action, focussing on D2/3 receptors. These studies show that Read More
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Functional Imaging as a Tool to Investigate the Relationship between Genetic Variation and Response to Treatment with Antipsychotics
Authors: A. Di Giorgio, F. Sambataro and A. BertolinoRecent evidence suggests that genetic variation is associated with individual variability in response to treatment with antipsychotics. Although numerous studies have been performed for identification of potential genetic variants affecting response to treatment, initial enthusiasm has been tempered by inconsistent results. Along with some specific methodological issues, another plausible explanation for such inconsistencies Read More
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What do ERPs and ERFs Reveal About the Effect of Antipsychotic Treatment on Cognition in Schizophrenia?
Authors: M. Korostenskaja and S. KahkonenCognitive dysfunction is considered to be a core feature in schizophrenia. It is believed that antipsychotic drugs, especially atypical ones, could improve cognitive functions in schizophrenia patients. Auditory event-related potentials (ERPs) such as mismatch negativity (MMN) and P300 response are potential candidates for objective investigation of pre-attentional and attention-dependent processing in schizophrenia pati Read More
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Imaging the Glutamate System in Humans: Relevance to Drug Discovery for Schizophrenia
More LessThere is growing evidence for the involvement of glutamatergic abnormalities in schizophrenia. Uncompetitive NMDA receptor (NMDAR) antagonists induce effects closely resembling both the positive and negative symptoms of schizophrenia; candidate risk genes for schizophrenia converge on the NMDAR expressing synapse; and a recent trial of a drug with direct action at metabotropic glutamate autoreceptors ha Read More
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Imaging the Neural Effects of Cannabinoids: Current Status and Future Opportunities for Psychopharmacology
Authors: S. Bhattacharyya, J. A. Crippa, R. Martin-Santos, T. Winton-Brown and P. Fusar-PoliAlthough recreational and medicinal use of cannabis has been known for many centuries, it is only in recent decades that it has again attracted considerable systematic attention because of its adverse psychological and potential beneficial effects. This has also been prompted by better understanding of the molecular targets of cannabinoids in the living organism. While cannabis has attracted the attention of mental heal Read More
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Connecting the Brain and New Drug Targets for Schizophrenia
Authors: H. C. Whalley, J. D. Steele, P. Mukherjee, L. Romaniuk, A. M. McIntosh, J. Hall and S. M. LawrieOne thing we know for certain after decades of functional imaging in schizophrenia is that it is not a disorder that can simply be attributed to circumscribed lesions in the brain. It is, in other words, a disorder of the connectivity of the brain. In this overview, we will consider the power of connectivity analyses of functional MRI (and PET) data as tools for translational neuroscience. We describe the patterns of functional an Read More
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Myelination in Bipolar Patients and the Effects of Mood Stabilizers on Brain Anatomy
Authors: Paolo Brambilla, Marcella Bellani, Ping-Hong Yeh and Jair C. SoaresIn this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.
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Neuroimaging and Genetics of Antidepressant Response to Sleep Deprivation: Implications for Drug Development
Authors: Francesco Benedetti and Enrico SmeraldiDespite confirmed evidences about some neurochemical effects of antidepressant treatments, there is still a high level of uncertainty about which biological changes are needed to recover from a major depressive episode. Changes of monoaminergic neurotransmission are paralleled by profound changes in brain metabolism, neural responses to stimuli, sleep architecture, biological rhythms, and, at the intracellular level, Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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