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- Volume 15, Issue 12, 2009
Current Pharmaceutical Design - Volume 15, Issue 12, 2009
Volume 15, Issue 12, 2009
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Editorial [Hot Topic: The Extracellular Matrix in Health and Disease(Executive Editor: Johannes A. Eble)]
More LessThe connective tissue is exceptional in terms of its huge versatility and variability. An important characteristic of the connective tissue is the intercellular space. The mesenchymal cells of the connective tissue are spaced widely apart and form a huge extracellular space between them. This space is filled with a dense meshwork of mainly fibrillar extracellular matrix (ECM) molecules, which together with elastic fibers best Read More
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Developmental and Pathogenic Mechanisms of Basement Membrane Assembly
Authors: Peter D. Yurchenco and Bruce L. PattonBasement membranes are sheet-like cell-adherent extracellular matrices that serve as cell substrata and solidphase agonists, contributing to tissue organization, stability and differentiation. These matrices are assembled as polymers of laminins and type IV collagens that are tethered to nidogens and proteoglycans. They bind to cell surface molecules that include signal-transducing receptors such as the integrins and dyst Read More
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A Fresh Prospect of Extracellular Matrix Hydrolytic Enzymes and Their Substrates
Authors: M. D. Roycik, X. Fang and Q.-X. SangExtracellular matrix (ECM) and ECM-hydrolytic enzymes play critical roles in reproduction, development, morphogenesis, wound healing, tissue repair, regeneration, and remodeling. They are also involved in pathological processes such as inflammation, arthritis, cardiovascular diseases, stroke, neurodegeneration, metabolic syndrome, and cancer invasion and metastasis. Other reviews summarized the structure and func Read More
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Cellular Receptors of Extracellular Matrix Molecules
Authors: Jyrki Heino and Jarmo KapylaExtracellular matrix (ECM) is composed of large collagen fibrils. Glycoproteins, such as fibronectin, can bind to collagen or form their own networks. Collagen fibrils are also decorated by proteoglycans, proteins that have large glycosaminoglycan sidechains. In addition, extracellular space often contains hyaluronan, a large glycosaminoglycan molecule that has no core protein. Basement membranes represent a specialized form Read More
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Regulation of Matrix Synthesis, Remodeling and Accumulation in Glomerulosclerosis
Authors: Ambra Pozzi, Paul A. Voziyan, Billy G. Hudson and Roy ZentAfter injury the body normally undergoes a repair process, however when this event becomes deregulated the pathological condition of fibrosis occurs. There are many similarities with respect to the fundamental mechanisms that regulate sclerosis in different organ systems. In this review we utilize the pathological entity of glomerulosclerosis in the kidney to highlight some of the general paradigms whereby extracellular m Read More
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Cartilage and Bone Extracellular Matrix
Authors: ChiaraGentili snm and Ranieri CanceddaThe extracellular matrix (ECM) is a complex of self assembled macromolecules. It is composed predominantly of collagens, non-collagenous glycoproteins, hyaluronan and proteoglycans. ECM is not only a scaffold for the cells; it serves also as a reservoir for growth factors and cytokines and modulates the cell activation status and turnover. ECM should be considered a dynamic network of molecules secreted by cells that Read More
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Multiple Roles of the Extracellular Matrix in Inflammation
Authors: E. Korpos, C. Wu and L. SorokinExtracellular matrix (ECM) provides a physical scaffold for cells but also provides specific molecular and spatial information that influences cell proliferation, differentiation and apoptosis. This review addresses the multiple roles of ECM in inflammatory responses, in particular in leukocyte extravasation at sites of inflammation, and the potential of exploiting such cell-ECM interactions to interfere with defined steps in the infl Read More
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Platelet Activation by Extracellular Matrix Proteins in Haemostasis and Thrombosis
More LessThe prevention of excessive blood loss to avoid fatal haemorrhage is a pivotal process for all organisms possessing a circulatory system. Increased circulating blood volume and pressure, as required in larger animals, make this process all the more important and challenging. It is essential to have a powerful and rapid system to detect damage and generate an effective seal, and which is also exquisitely regulated to prevent u Read More
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The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment
Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in today's routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the accumulation Read More
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The Extracellular Matrix of Blood Vessels
Authors: Johannes A. Eble and Stephan NilandBlood vessels are highly organized and complex structure, which are far more than simple tubes conducting the blood to almost any tissue of the body. They are able to autonomously regulate the blood flow, thus providing the tissues an optimal support of oxygen and nutrients and an efficient removal of waste products. In higher organisms, the blood vessel forms a closed circuit system, which additionally has the ability to seal Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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