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- Volume 15, Issue 34, 2009
Current Pharmaceutical Design - Volume 15, Issue 34, 2009
Volume 15, Issue 34, 2009
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Editorial [Hot topic: New Therapeutic Strategies for Treatment of Neurodegenerative Diseases (Executive Editor: Aleksey G. Kazantsev)]
More LessCurrently there is no cure for neurodegenerative disorders such as Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, and many others, which cause long-term suffering and ultimately death of patients. These devastating neurodegenerative diseases affect the lives of many thousands of patients and their families. Basic research on neurodegenerative disorders has revealed a highly complex picture Read More
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Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions
By G. D. CunyKinases, which number > 500 in humans, are a class of enzymes that participate in an array of important functions within normal cellular physiology and during various pathological conditions. Due to the key role of kinases in the regulation of all aspects of cellular signaling and the well established contribution of kinase dysregulation to the etiology of many human pathologies, the development of kinase inhibitors has e Read More
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Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise
Authors: Antonello Mai, Dante Rotili, Sergio Valente and Aleksey G. KazantsevNeurodegenerative disorders (NDs) such as Huntington's disease, Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis, spinal muscular atrophy, Friedreich's ataxia, and others are multi-factorial illnesses, in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. Thus, presently there are no effective cures for these diseases. Some phenotypic as Read More
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Turning REST/NRSF Dysfunction in Huntington's Disease into a Pharmaceutical Target
Authors: Dorotea Rigamonti, Cesare Mutti, Chiara Zuccato, Elena Cattaneo and Alessandro ContiniREST/NRSF is a transcription factor that represses transcription of several neuronal genes by binding to a DNA regulatory motif known as Repressor Element 1/Neuron-restrictive silencer element (RE1/NRSE). In Huntington's Disease, an inherited degenerative disease affecting the brain, REST/NRSF enters pathologically into the nucleus of affected cells, leading to the activation of the RE1/NRSE sites and causing decreased Read More
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Current and Future Therapeutic Strategies for Parkinson's Disease
Authors: Tiago F. Outeiro and Joaquim FerreiraThe heterogeneity of symptoms and disease progression observed in synucleinopathies, of which Parkinson's disease (PD) is the most common representative, poses large problems for its treatment and for the discovery of novel therapeutics. The molecular basis for pathology is currently unclear, both in familial and in sporadic cases. While the therapeutic effects of L-DOPA and dopamine receptor agonists are still the gold Read More
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RNAi Applications in Therapy Development for Neurodegenerative Disease
More LessRNA-mediated interference (RNAi) is a powerful tool for experimental manipulation of gene expression and is widely used to investigate gene function both in vitro and in vivo. RNAi refers to an evolutionarily conserved cellular mechanism for sequence-specific post-transcriptional gene silencing, in which double-stranded RNAs promote selective degradation of homologous cellular mRNAs. Because RNAi-based technique Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
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- Issue 8
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- Issue 2
- Issue 1
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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