- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 13, Issue 32, 2007
Current Pharmaceutical Design - Volume 13, Issue 32, 2007
Volume 13, Issue 32, 2007
-
-
Editorial [Hot Topic:Resent and Future Therapies for the Hepatocellular Carcinoma (Executive Editor: G. Giannelli)]
By G. GiannelliHepatocellular carcinoma (HCC) is becoming a major health problem worldwide, both because of the constantly rising number of patients and of the poor prognosis of this disease. Therapies adopted so far mainly fight the cancer by removing the tumor or the whole liver whenever possible by transplantation, or by destroying it either by alcoholization, radiofrequency ablation (RFA) or transarterial chemoembolization (TACE). Th Read More
-
-
-
Liver Transplantation for Hepatocellular Carcinoma: Current Role and Future Opportunities
Authors: Felicitas L. Koller, Sunil K. Geevarghese and D. L. GordenHepatocellular carcinoma (HCC) is the most common primary malignancy of the liver. It represents the fifth most common cancer worldwide, and one whose incidence is on the rise. Liver cancer is the third most common cause of cancer mortality globally and thus a major health concern worldwide. Therapeutic options for this tumor include surgical resection, local ablative therapies, and systemic treatment. Liver transpla Read More
-
-
-
Transcutaneous Treatments of Hepatocellular Carcinoma in Patients with Cirrhosis: Present Status and Future Developments
Authors: Michel Beaugrand and Olivier SeroHepatocellular carcinoma is in 90% of cases associated with cirrhosis and to preserve liver function while destroying the tumor is a main issue in these patients justifying the development of local percutaneous ablative therapies. Alcoholization and radiofrequency ablation are the most widely used techniques of percutaneous ablation. Both have in common limitations linked to the size of the tumor and its situation and contra i Read More
-
-
-
Molecular Pathways and Related Target Therapies in Liver Carcinoma
Authors: S. Tommasi, R. Pinto, B. Pilato and A. ParadisoHepatocellular carcinoma (HCC) is a frequent neoplasia which still misses a therapeutical gold standard. Recently, new acquisitions in cancerogenesis process evidenced the genetic and epigenetic alterations of genes involved in the different metabolic pathways of liver cancer suggesting that antibodies, small molecules, demethylating agents, etc. specifically acting against molecular target can be utilized alone Read More
-
-
-
Rationale for New Drugs Targeting the Tissue Microenvironment in Patients with HCC
Authors: S. Antonaci and G. GiannelliA better knowledge of the mechanisms underlying hepatocellular carcinoma (HCC) growth and spread is essential to improve the available treatment options. So far, the only therapies available for HCC are mainly based on tumor-destructive approaches, whereas no therapies are available to consolidate these invasive therapies or to cure the tumor. The fact that HCC develops on cirrhotic liver strongly limits the us Read More
-
-
-
The Development of Targeted Therapies for Hepatocellular Cancer
Authors: D. Chattopadhyay, D. M. Manas and H. L. ReevesPresent treatment options for hepatocellular cancer (HCC) are limited to those individuals with good liver function and early stage disease. Unfortunately this includes only a minority of patients, few of which are actually cured of their cancer. Over the last 15-20 years biotechnology has made a very significant impact on medical research, to the extent that we know very much more about the regulation of normal cell gr Read More
-
-
-
Tyrosine Kinase Inhibitors: A Potential Approach to the Treatment of Hepatocellular Carcinoma
Authors: G. Giannelli, N. Napoli and S. AntonaciThe increasing number of patients with hepatocellular carcinoma (HCC) and the highly unfavourable prognosis of the disease are two important reasons why more effort needs to be devoted to investigating other therapies able to block or reduce tumor progression and cancer metastasis. The underlying cirrhosis on which HCC develops limits the use of common chemotherapies, mainly because of their toxicity. Recently, gr Read More
-
-
-
Cyclooxygenase-2 (COX-2) - A Therapeutic Target in Liver Cancer?
Authors: Marco Breinig, Peter Schirmacher and Michael A. KernTargeting COX-2, a key-enzyme of the prostaglandin metabolism, for the treatment of cancer has been in the focus of researchers for about a decade. However, only recently has this topic been related to hepatocellular carcinoma (HCC). HCC is one of the most common cancers and a growing health problem worldwide. At present, only few promising treatment options are available, accentuating the urgent need for no Read More
-
-
-
Editorial [Hot Topic:MALDI Imaging of Biomolecules (Executive Editor: Michel Salzet)]
More LessRecent studies performed these last years on the proteome have demonstrated the usefulness of mass spectrometry The combination of mass spectrometry with classical biochemical methods has lead to the determination and identification of different proteins using proteomics studies in close relation with genome databases. Although such methods generally lead to the identification of novel proteins, they do not allow de Read More
-
-
-
New Developments in MALDI Imaging for Pathology Proteomic Studies
With new emerging mass spectrometry technologies, it can now be demonstrated that direct tissue analysis is feasible using matrix-assisted laser desorption/ionization (MALDI) sources. A major advantage of direct MALDI analysis is to avoid time-consuming extraction, purification or separation steps, which have the potential for producing artifacts. Direct MALDI analysis of tissue sections enables the acquisition of cellular expres Read More
-
-
-
Mass Spectrometric Imaging of the Nervous System
Authors: S. S. Rubakhin, N. G. Hatcher, E. B. Monroe, M. L. Heien and J. V. SweedlerMass spectrometric imaging (MSI) integrates multiple fields of analytical and biomedical research with the goal of generating chemical maps that present the identity and location of the elements, molecules, and molecular complexes that comprise biological structures. Rapid advances in the development of MSI, which include a broad range of sampling and mass spectrometry strategies, allow the increasingly information-rich Read More
-
-
-
Recent Advances in Biological Tissue Imaging with Time-of-Flight Secondary Ion Mass Spectrometry: Polyatomic Ion Sources, Sample Preparation, and Applications
Authors: Alain Brunelle and Olivier LaprevoteRecent technological and methodological improvements have greatly enhanced the sensitivity of the Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS), thus making this technique now very attractive in the field of molecular imaging of biological samples such as tissue sections or cells. This paper reviews the most recent advances in this field. After a short reminder of the basic physics involved, the instr Read More
-
-
-
A Snapshot of Tissue Glycerolipids
Authors: Amina S. Woods, Hay-Yan J. Wang and Shelley N. JacksonThe lipid membrane is the portal to the cell and its first line of defense against the outside world. Its plasticity, diversity and powers of accommodation in a myriad of environments, mirrored by the varied make up of the cells it protects, are unparalleled. Glycerophospholipids are one of its major components. In cell membranes the extracellular layer is mainly made up of positively charged glycolipids, while the intr Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
-
Volume 13 (2007)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
