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- Volume 13, Issue 17, 2007
Current Pharmaceutical Design - Volume 13, Issue 17, 2007
Volume 13, Issue 17, 2007
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Editorial [Hot Topic: Trends in Vascular Biology; Functional Restoration of Damaged Endothelium (Executive Editors: J.A. Rodriguez-Feo and G. Pasterkamp)]
Authors: Juan A. Rodriguez-Feo and Gerard PasterkampEndothelial injury and dysfunction are early alterations in vessel wall biology preceding atherosclerotic plaque formation. In the presence of established cardiovascular risk factors, endothelial cells are constantly injured and repaired by the proliferation of resident cells and circulating endothelial progenitor cells. The maintenance of the endothelial layer physical continuity and function represents a major target for the Read More
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Understanding eNOS for Pharmacological Modulation of Endothelial Function: A Translational View
Authors: Branko Braam and Marianne C. VerhaarKnowledge about the function of endothelial nitric oxide synthase (eNOS), and its regulation in pathophysiological states has tremendously increased. It is now clear that diminished activity of nitric oxide (NO) contributes to endothelial dysfunction, which is a characteristic of impeding atherosclerosis. This review aims to summarize the available knowledge about the impact of important cardiovascular risk factors on N Read More
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Endothelial Function: A Surrogate Endpoint in Cardiovascular Studies?
Authors: Matthias Frick and Franz WeidingerEndothelial dysfunction is a well documented early phenomenon in atherosclerosis. Because it may precede structural changes and clinical manifestations, major research efforts have focused on the detection of endothelial dysfunction in humans. The utility of such tests in clinical practice critically depends on the proof of their prognostic value, their safety and reproducibility. First data supporting the prognostic im Read More
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The Dialogue Between Endothelial Cells and Monocytes/Macrophages in Vascular Syndromes
Authors: J. Martin, S. Collot-Teixeira, L. McGregor and J. L. McGregorThe aim of this chapter is to present and identify potential pharmacological targets in endothelial cell-monocyte interactions leading to vascular syndrome and involving inflammation, coagulation, vascular remodelling and thrombosis. Increasing evidence is indicating that endothelial cells play a key role in atherothombosis by their capacity to attract, bind and allow the extravasation of monocytes to sites of inflammation. S Read More
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Caveolae and Caveolin-1: Novel Potential Targets for the Treatment of Cardiovascular Disease
Authors: Philippe G. Frank, Ghada S. Hassan, Juan A. Rodriguez-Feo and Michael P. LisantiCaveolae are 50-100 nm cell surface plasma membrane invaginations that are highly enriched in cholesterol and sphingolipids and are characterized by the protein marker caveolin-1. Caveolin-1 is highly expressed in terminally differentiated cells. Among these cells, endothelial cells, smooth muscle cells, and macrophages have all been shown to play key roles in the development of vascular disease. Atherosclerosis a Read More
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Influence of Statin Use on Endothelial Function: From Bench to Clinics
Authors: Jose Martinez-Gonzalez and Lina BadimonEndothelial dysfunction has been shown to be a prognostic factor for cardiovascular disease and improvement of endothelial dysfunction prevents cardiovascular event presentation. Endothelial dysfunction is associated to a reduced nitric oxide (NO) bioactivity, as a result of the impairment of NO synthesis/release by the endothelial NO synthase (eNOS) or by inactivation of NO. Endothelial dysfunction measurements are valuabl Read More
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Matrix Metalloproteinases: New Routes to the Use of MT1-MMP As A Therapeutic Target in Angiogenesis-Related Disease
Authors: A. G. Arroyo, L. Genis, P. Gonzalo, S. Matias-Roman, A. Pollan and B. G. GalvezAngiogenesis, the formation of new vessels from pre-existing capillaries, is a fundamental physiological process which is also critical for the development of several pathological conditions; thus a diminished angiogenic response is related to ischemic disorders, whereas increased angiogenesis is associated with tumorigenesis and chronic inflammatory diseases. New ways of modulating angiogenesis therefore have Read More
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Growth Factor Therapy in Atherosclerotic Disease-Friend or Foe
Authors: Imo E. Hoefer, Leo Timmers and Jan J. PiekStimulation of neovascularization (angiogenesis, arteriogenesis) has emerged as a promising new strategy to treat patients with coronary disease. These strategies aim to improve cardiac function by ensuring myocardial perfusion and to reduce the risk of myocardial infarction. While angiogenesis describes a de-novo formation of small caliber capillary vessels, arteriogenesis leads to the outgrowth of pre-existing arter Read More
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The Importance of Reendothelialization After Arterial Injury
Authors: D. Versari, L. O. Lerman and A. LermanAtherosclerosis is still the principal cause of morbidity and mortality in Western countries and although a significant progress has been made in the understanding of its pathophysiology, the determinants of atherosclerotic plaque instability are still poorly understood. The endothelium plays a pivotal role for the development, progression, and complication of atherosclerosis. Endothelial dysfunction is widely recognized as one o Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
- Issue 26
- Issue 25
- Issue 24
- Issue 23
- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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