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- Volume 12, Issue 36, 2006
Current Pharmaceutical Design - Volume 12, Issue 36, 2006
Volume 12, Issue 36, 2006
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Editorial [Hot Topic: Nanomedicine and Drug Delivery (Executive Editors: A.V. Kabanov and K. Levon)]
Authors: Alexander V. Kabanov and Kalle LevonA new interdisciplinary field of nanomedicine that promises breakthrough advances to human health has emerged over last years. This field develops innovative nanomaterials, tools and devices operating at the nanoscale to diagnose, treat, prevent and monitor diseases and traumatic injury, relieve pain, and, overall, preserve and improve the human health [1]. This field joins physical and engineering sciences with phar Read More
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Polymeric Micelles for Drug Delivery
Authors: S. R. Croy and G. S. KwonPolymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes. An emphasis of this review has been placed on both the description and characterization techniques of the physical properties of polymeric micelles. Relevant properties discussed include micel Read More
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Formulation of Drugs in Block Copolymer Micelles: Drug Loading and Release
More LessBlock copolymer micelles have become accepted as a viable strategy for drug formulation and delivery. Block copolymer micelles may serve as solubilizers and/or true drug carriers depending on their drug retention properties in vivo. Indeed the formulation of hydrophobic drugs in these micelle systems has been shown to provide up to a 30 000 fold increase in the water solubility of some compounds. In addition, the adm Read More
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Colloidal Microgels in Drug Delivery Applications
More LessColloidal microgels have recently received attention as environmentally responsive systems and now are increasingly used in applications as carriers for therapeutic drugs and diagnostic agents. Synthetic microgels consist of a crosslinked polymer network that provides a depot for loaded drugs, protection against environmental hazards and template for post-synthetic modification or vectorization of the drug carriers. The Read More
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Liposome-Nanogel Structures for Future Pharmaceutical Applications
Authors: Sergey Kazakov and Kalle LevonNanoparticles have been extensively studied as drug delivery systems. In this review, we focus on a relatively new type of nanoparticles - lipobeads - a liposome-hydrogel assembly as a novel drug delivery system. An appropriate assemblage of spherical hydrogel particles and liposomes combines the properties of both classes of materials and may find a variety of biomedical applications. The bi-compartmental structure Read More
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Nanocarriers for Nuclear Imaging and Radiotherapy of Cancer
Authors: Amitava Mitra, Anjan Nan, Bruce R. Line and Hamidreza GhandehariSeveral nanoscale carriers (nanoparticles, liposomes, water-soluble polymers, micelles and dendrimers) have been developed for targeted delivery of cancer diagnostic and therapeutic agents. These carriers can selectively target cancer sites and carry large payloads, thereby improving cancer detection and therapy effectiveness. Further, the combination of newer nuclear imaging techniques providing high sensitivity and spatial Read More
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The Role of Electrospinning in the Emerging Field of Nanomedicine
Authors: S. Y. Chew, Y. Wen, Y. Dzenis and K. W. LeongThe fact that in vivo the extracellular matrix (ECM) or substratum with which cells interact often includes topography at the nanoscale underscores the importance of investigating cell-substrate interactions and performing cell culture at the submicron scale. An important and exciting direction of research in nanomedicine would be to gain an understanding and exploit the cellular response to nanostructures. Electrospinning is a Read More
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Statins and Solid Organ Transplantation
Authors: I. F. Gazi, E. N. Liberopoulos, V. G. Athyros, M. Elisaf and D. P. MikhailidisDyslipidaemia is common in solid organ transplant recipients and its presence is associated with chronic rejection and accelerated atherosclerosis, leading to an increased prevalence of cardiovascular disease (CVD). CVD is a major cause of morbidity and mortality in transplant recipients. It is therefore of interest and clinical value to introduce agents that effectively and safely reduce the incidence of this outcome. In the prese Read More
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Exploiting EPR in Polymer Drug Conjugate Delivery for Tumor Targeting
Authors: Sweta Modi, Jay Prakash Jain, A. J. Domb and Neeraj KumarTreatment of tumor tissue without affecting normal cells has always been formidable task for drug delivery scientists and this task is effectively executed by polymer drug conjugate (PDC) delivery. The novelty of this concept lies in the utilization of a physical mechanism called enhanced permeability and retention (EPR) for targeting tumors. EPR is a physiological phenomenon that is customary for fast growing tumor and Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
- Issue 27
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- Issue 12
- Issue 11
- Issue 10
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- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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