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- Volume 12, Issue 11, 2006
Current Pharmaceutical Design - Volume 12, Issue 11, 2006
Volume 12, Issue 11, 2006
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Editorial [Hot Topic: Recent Advances in Antiviral Agents (Executive Editor: Shin-Ru Shih)]
By Shin R. ShihOver 400 pathogenic viruses that infect humans have been identified. Moreover, newly emerging viruses, such as SARS-CoV, and avian flu, post a constant threat. Unfortunately, only limited approved treatments exist for viral infections. Therefore, it is urgent and crucial to develop more effective and nontoxic antiviral agents. In preparation this issue, we have sought to provide useful information for scientists with an inter Read More
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Antiviral Drug Discovery Targeting to Viral Proteases
Authors: John T. A. Hsu, Hsiang-Ching Wang, Guang-Wu Chen and Shin-Ru ShihProteases fulfill multiple roles in health and disease, and considerable interest has been expressed in the design and development of synthetic inhibitors of disease-related proteases. Virus-encoded proteases have been shown to be involved in the replication of many viruses. The success of anti-HIV-1 therapy using specific and potent protease inhibitors suggests that viral proteases can be the valid molecular targets for the d Read More
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Understanding Helicases as a Means of Virus Control
Authors: D. N. Frick and A. M. I. LamHelicases are promising antiviral drug targets because their enzymatic activities are essential for viral genome replication, transcription, and translation. Numerous potent inhibitors of helicases encoded by herpes simplex virus, severe acute respiratory syndrome coronavirus, hepatitis C virus, Japanese encephalitis virus, West Nile virus, and human papillomavirus have been recently reported in the scientific literature. So Read More
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Antiviral Therapy Targeting Viral Polymerase
Authors: Ching-Hsiu Tsai, Pei-Yu Lee, Victor Stollar and Mei-Ling LiViral DNA and RNA polymerases are enzymes, which are responsible for copying the genetic materials of viruses and are therefore central components in the life cycles of viruses. The polymerases are essentially required for the replication of viruses. The reverse transcriptase (RT) of the retroviruses and the hepadnaviruses is the sole viral enzyme required for the synthesis of DNA from viral RNA. Viral polymerases ar Read More
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Herpes Simplex Viruses in Antiviral Drug Discovery
More LessSince the 1950's, herpes simplex viruses (HSV) have played prominent roles in the development of antivirals. The first efficacious antivirals, as well as the first safe for systemic use, were developed against HSV. It was only in 1995 when the first antiviral against a target not validated first with HSV was approved for clinical use (sequinavir). The early successes of targeting HSV DNA replication were most influential in developing Read More
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Recent Advances in Antiviral Agents: Antiviral Drug Discovery for Hepatitis Viruses
By K. TanikawaHepatitis B virus (HBV)- or hepatitis C virus (HCV)- associated liver diseases are now one of the important health problems in the world because of the high numbers of patients and the serious consequences. Recently, however, relatively effective treatments with antiviral agents have become available. Interferon (IFN), lamivudine and adefovir are now approved for treatment of HBV-associated liver diseases and they have bee Read More
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Current Status of Anti-Picornavirus Therapies
More LessPicornaviruses are important human pathogens causing severe morbidity and some mortality with the potential to cause worldwide crippling disease. Currently, there are few treatments for many of the viruses in the Picornaviridae, For rhinoviruses, there are no approved treatments, although ruprintrivir looks promising in clinical trials and pyridazinyl oxime ethers may prove useful. Poliovirus treatments are needed to Read More
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New Strategies for Immune-Mediated Anti-Viral Drug and Vaccine Development
Authors: Chiann-Chyi Chen and Yacov RonSubstantial progress in the development of new anti-viral drugs has taken place in recent years. Most of these new drugs belong to three groups of compounds, nucleoside analogs, thymidine kinase-dependent nucleotide analogs and specific viral enzyme inhibitors. Although these drugs revolutionized the treatment of several viral diseases, the involvement of the immune system is crucial for complete recovery and prev Read More
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Soft Condensed Matter in Pharmaceutical Design
Authors: Gaio Paradossi, Francesca Cavalieri and Ester ChiessiIn recent years pharmaceutical design has been facing the needs expressed by new therapeutic methodologies such as gene therapy, targeted delivery and closely related diagnostic fields as contrast enhancing agents for ultrasonic investigations. In this context pharmaceutical research has diversified the efforts toward a more integrated approach where the efficacy of an active molecule is enhanced and assisted by the surr Read More
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Porcine Cytochrome P450 and Metabolism
More LessThe pig and especially the minipig are becoming increasingly used as a test animal both in pharmacological and toxicological testing of new compounds. The minipig is used because of its size, it is easy to handle and less test substrate is required. When using an animal species for testing it is of importance to know if the test animal's posses the same abilities to metabolize drugs as humans. Some of the P450 enzymes hav Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
- Issue 36
- Issue 35
- Issue 34
- Issue 33
- Issue 32
- Issue 31
- Issue 30
- Issue 29
- Issue 28
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- Issue 22
- Issue 21
- Issue 20
- Issue 19
- Issue 18
- Issue 17
- Issue 16
- Issue 15
- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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