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- Volume 12, Issue 16, 2006
Current Pharmaceutical Design - Volume 12, Issue 16, 2006
Volume 12, Issue 16, 2006
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Editorial [Hot Topic: HIV Drug Design (Executive Editor: A.S. Bourinbaiar)]
More LessThe need to discover novel means to treat HIV infection remains as critical as ever since the epidemic of AIDS continues to grow unabated. The emergence of resistant virus strains and the toxic side effects of current drugs require new classes of therapeutic agents with better and safer properties. In this issue of "Current Pharmaceutical Design" several authors review their effort of accomplishing this task. Debra Meyer p Read More
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Iron Chelation as Therapy for HIV and Mycobacterium tuberculosis Co-Infection Under Conditions of Iron Overload
By Debra MeyerIron chelators, as treatment for conditions of iron overload, have implications for AIDS and tuberculosis (TB) since excess iron in the system assists HIV and Mycobacterium tuberculosis (M.tb) multiplication. Excess iron, especially due to dietary habits, is almost as common in sub-Saharan Africa as infections by the two organisms. That HIV and M.tb influence each other's replication during co-infection is well established, but in vitr Read More
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Potential Use of Pharmacological Cyclin-Dependent Kinase Inhibitors as Anti-HIV Therapeutics
Authors: Anne Pumfery, Cynthia d. l. Fuente, Reem Berro, Sergei Nekhai, Fatah Kashanchi and Sheng-Hao ChaoCyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II transcription. Several pharmacological CDK inhibitors (PCIs) are currently in clinical trials as potential cancer therapeutics since CDK hyperactivation is detected in the majority of neoplasias. Within the last few years, the anti-viral effects of PCIs have also been observed against various viruses, including human immunodeficiency virus (H Read More
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Cellular Entry of HIV: Evaluation of Therapeutic Targets
Authors: Stefan Pohlmann and Jacqueline D ReevesIn the absence of a vaccine which could stop the HIV/AIDS pandemic, the development of therapeutic options is of utmost interest. The combined use of inhibitors of reverse transcriptase and protease as highly active antiretroviral therapy (HAART) provided the first effective treatment of HIV/AIDS and significantly decreased the number of AIDS related deaths in industrialized countries. However, the emergence of resistan Read More
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Chromatin Modifications (Acetylation/ Deacetylation/ Methylation) As New Targets for HIV Therapy
Authors: Radhika A. Varier and Tapas K. KunduHuman immunodeficiency virus (HIV) is one of the most deadly threats to the human race. Though the developed countries have been able to control the epidemic by utilizing the discovery of very expensive diagnostics, the situation is dangerously alarming in developing and underdeveloped countries. However, development of highly active antiretroviral drugs has improved the survival and quality of life, but Read More
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Recent Developments in Delivery of Nucleic Acid-Based Antiviral Agents
Authors: M. E. Christopher and J. P. WongRapid advances in viral genomics, gene function and regulation, as well as in rational drug design, have led to the development of gene-based drugs that can induce protective antiviral immunity, interfere with viral replication, suppress viral gene expression or cleave viral mRNAs. Several such drug candidates have been developed in recent years against various viruses including HIV. Although gene-based agents show pro Read More
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Recombinant Human Polyclonal Antibodies: A New Class of Therapeutic Antibodies Against Viral Infections
Authors: Søren Bregenholt, Allan Jensen, Johan Lantto, Sara Hyldig and John S. HaurumThe mammalian immune system eliminates pathogens by generating a specific antibody response. Polyclonality is a key feature of this immune response: the immune system produces antibodies which bind to different structures on a given pathogen thereby increasing the likelihood of its elimination. The vast majority of current recombinant antibody drugs rely on monospecific monoclonal antibodies. Inherently, such antib Read More
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Therapeutic AIDS Vaccines
Therapeutic HIV vaccines represent promising strategy as an adjunct or alternative to current antiretroviral treatment options for HIV. Unlike prophylactic AIDS vaccines designed to prevent HIV infection, therapeutic vaccines are given to already infected individuals to help fight the disease by modulating their immune response. The first immunotherapeutic trial in AIDS patients was conducted in 1983. Since then several doz Read More
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Anti-HIV Therapy: Current and Future Directions
Authors: Lokesh Agrawal, Xihua Lu, Qingwen Jin and Ghalib AlkhatibAlthough combinations of drugs that target the HIV reverse transcriptase and protease enzymes have clearly revolutionized the treatment of HIV/AIDS, problems with these agents, such as viral escape mutants, persistence of viral reservoirs, poor patient compliance due to complicated regimens, and toxic side effects, have emphasized the need for development of new drugs with novel mechanisms of action, as well as Read More
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Effects of ACE Inhibitors on Skeletal Muscle
Authors: Graziano Ondera, Cecilia D. Vedova and Marco PahorcAngiotensin-converting enzyme (ACE) inhibitors reduce morbidity, mortality, hospital admissions, and decline in physical function and exercise capacity in congestive heart failure (CHF) patients. These therapeutic effects are attributed primarily to beneficial cardiovascular actions of these drugs. However, it has been suggested that ACE inhibitorinduced positive effects may also be mediated by direct action on the skeletal Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
- Issue 36
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- Issue 32
- Issue 31
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- Issue 19
- Issue 18
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- Issue 16
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- Issue 14
- Issue 13
- Issue 12
- Issue 11
- Issue 10
- Issue 9
- Issue 8
- Issue 7
- Issue 6
- Issue 5
- Issue 4
- Issue 3
- Issue 2
- Issue 1
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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