- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 10, Issue 20, 2004
Current Pharmaceutical Design - Volume 10, Issue 20, 2004
Volume 10, Issue 20, 2004
-
-
Cardiac Sarcolemmal Ion Channels and Transporters as Possible Targets for Antiarrhythmic and Positive Inotropic Drugs: Strategies of the Past-Perspectives of the Future
Authors: Andras Varro, Peter P. Nanasi, Karoly Acsai, Laszlo Virag and Julius Gy. PappIn this article we overview the most important antiarrhythmic and positive inotropic mechanisms based on pharmacological modification of an ion channel or a transport protein in the surface membrane of cardiac myocytes. First we briefly characterize the ion currents mediated by these proteins in atrial and ventricular cells. Since the level of expression of ion channels is markedly altered in various types of chronic heart Read More
-
-
-
The Opioid Receptor Independent Actions of Kappa Receptor Agonists in the Cardiovascular System
More LessIt is not well known but the actions of opioid receptor agonist and antagonist drugs have not been well characterized in the heart and cardiovascular system. Under normal physiological conditions, opioid receptors have a limited role in the regulation of the cardiovascular system. Instead the primary focus of opioid receptor research, for many years, relates to the characterization of the actions as analgesics in the Read More
-
-
-
Possible Therapeutic Targets in Cardiac Myocyte Apoptosis
Authors: P. Andreka, Z. Nadhazi, G. Muzes, G. Szantho, L. Vandor, L. Konya, M. S. Turner, Z. Tulassay and N. H. BishopricSince Kerr described programmed cell death (apoptosis) as a process distinct from necrosis, there have been many studies of apoptosis in disease, especially of immunological origin. Because cardiac myocytes are terminally differentiated cells, they have typically been assumed to die exclusively by necrosis. However, during the last decade this view has been challenged by several studies demonstrating that a significa Read More
-
-
-
Cardiovascular Side Effects of New Antidepressants and Antipsychotics: New Drugs, old Concerns?
Authors: Pal Pacher and Valeria KecskemetiThe cardiovascular toxicity of older generation of tricyclic antidepressants (e.g. imipramine, desipramine, amitriptyline, clomipramine) and neuroleptics (e.g. haloperidol, droperidol, thioridazine, pimozide) is well established. These drugs inhibit cardiovascular Na+, Ca2+ and K+ channels often leading to life-threatening arrhythmia. To overcome the toxicity of old generation of antidepressants and antipsychotics, selective Read More
-
-
-
Acute Actions of Natriuretic Peptides in Coronary Vasculature and Ischaemic Myocardium
Authors: Yohann Rautureau and Gary F. BaxterThe natriuretic peptides are a family of widely distributed polypeptide mediators that exert a range of actions in several body systems. In cardiovascular homeostasis, the endocrine roles of the cardiac-derived atrial and B-type natriuretic peptide (ANP and BNP) in regulating central fluid volume and blood pressure have been recognised for two decades. However, there is a growing realisation that natriuretic peptide Read More
-
-
-
Interaction of NO and VIP in Gastrointestinal Smooth Muscle Relaxation
Authors: L.A. V. Geldre and R. A. LefebvreGastrointestinal (GI) smooth muscle cell activity is controlled by contractile cholinergic neurons and relaxant non-adrenergic non-cholinergic (NANC) neurons in the myenteric plexus between the circular and longitudinal muscle layer. Decreased or increased NANC relaxation might be involved in the pathophysiology of functional GI motility disorders. Vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) are the primary inhibi Read More
-
-
-
Regulation of Myometrial Smooth Muscle Functions
Authors: F. Hertelendy and T. ZakarRegulation of myometrial functions during gestation, labor and birth are in the forefront of research in reproductive sciences. The complexity of the problem is reflected by our scant understanding of the intimate cellular and molecular events underlying these phenomena, despite extensive efforts spanning several decades. Unlike other smooth muscles, the myometrium is, to a large extent, under hormonal control. Of these, Read More
-
-
-
Regulation of the Activity of the Human Drug Metabolizing Enzyme Arylamine N-Acetyltransferase 1: Role of Genetic and Non Genetic Factors
Authors: Fernando Rodrigues-Lima and Jean-Marie DupretHuman arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) are polymorphic phase II xenobioticmetabolising enzymes (XME) that acetylate arylamine compounds. They therefore play an important role in the detoxication and / or metabolic activation of certain therapeutic drugs, occupational chemicals and carcinogens. Although the use of the term “xenobiotic” implies that XME form a separate and distinct class Read More
-
-
-
The Therapeutic Potential of Hepatocyte Growth Factor for Myocardial Infarction and Heart Failure
Authors: Hongkui Jin, J. M. Wyss, Renhui Yang and Ralph SchwallHepatocyte growth factor (HGF) is a cytokine whose multipotent actions are mediated by c-Met receptor. This review focuses on effects of HGF on myocardial infarction (MI) and heart failure. Circulating concentrations of HGF and myocardial concentrations of HGF and c-Met mRNA and protein are substantially increased following acute MI. HGF has been shown to be cardioprotective towards acute cardiac ischemia-reperfusion i Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
-
Volume 13 (2007)
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
