- Home
- A-Z Publications
- Current Pharmaceutical Design
- Previous Issues
- Volume 10, Issue 23, 2004
Current Pharmaceutical Design - Volume 10, Issue 23, 2004
Volume 10, Issue 23, 2004
-
-
Transcription Factors in Autoimmune Diseases
Authors: Martin Eggert, Andreas Kluter, Uwe K. Zettl and Gunther NeeckThe analysis of the molecular basis of autoimmune diseases is currently under intense investigation. The identification of novel mechanisms underlying the pathogenesis of these diseases generates the possibility for the development of new therapeutic agents. In this review we summarize the results leading to novel insights concerning the molecular processes involved in the pathogenesis of rheumatoid arthritis, Read More
-
-
-
Immunomodulatory Activities of Glucocorticoids: Insights from Transgenesis and Gene Targeting
More LessThe glucocorticoid receptor (GR) is involved in the regulation of numerous physiological processes. In the immune system, it is thought to participate in lymphocyte apoptosis, T cell development and inflammatory responses. The extensive use of synthetic glucocorticoids as anti-inflammatory, immunosuppressive and anti-neoplastic drugs underscores the importance of the GR in immunomodulation. However, no Read More
-
-
-
Negative Glucocorticoid Receptor Response Elements and their Role in Glucocorticoid Action
Authors: Dostert A. and Heinzel T.The glucocorticoid receptor (GR) belongs to the steroid hormone receptor subclass of nuclear receptors and controls physiological processes through activation and repression of specific target genes. The ligand-activated receptor dimer activates gene expression by binding to specific DNA sequences (glucocorticoid response element, GRE) in the promoter regions of glucocorticoid-regulated genes. In contrast to the re Read More
-
-
-
Novel Ligands: Fine Tuning the Transcriptional Activity of the Glucocorticoid Receptor
More LessGlucocorticoids are the first line medication used in the therapy of many severe inflammatory disorders. They exert their activity through binding to the glucocorticoid receptor, a ligand-dependent transcription factor, and result in either activation or repression of a large set of glucocorticoid responsive genes. The desired immunosuppressive effect is apparently due largely to the down-regulation of a variety of pro-inflammat Read More
-
-
-
The NF-kB Pathway as a Potential Target for Autoimmune Disease Therapy
Authors: Susanne Bacher and M. L. SchmitzA battery of proinflammatory agents triggers the activation of NF-κB. This inducible transcription factor participates in the expression of an exceptionally large number of target genes, many of them contributing to the regulation of innate and adaptive immunity. Since some target genes also function as NF-κB activators, activation of this transcription factor allows the establishment of a signal amplification loop. Dysregula Read More
-
-
-
The Role of STATs in Inflammation and Inflammatory Diseases
Authors: E. Pfitzner, S. Kliem, D. Baus and M. C. LitterstThe immune response is regulated by the concerted action of pro- and anti-inflammatory cytokines. The deregulation of this process causes immunological disorders like allergic and autoimmune diseases. The Janus Kinase (JAK) - Signal transducer and activator of transcription (STAT) pathway is one major signaling pathway converting the cytokine signal into gene expression programs regulating the proliferation and di Read More
-
-
-
Nuclear Architecture and Gene Expression in the Quest for Novel Therapeutics
More LessThe architecture of the cell nucleus has long been a matter of debate, and is still not completely understood yet. However, much progress has been made in the last few years, gradually unraveling nuclear infrastructure and its importance of the regulation of key genetic events. It is now established that the readout of genetic information and its faithful duplication are not only affected by regulatory sequences in the geno Read More
-
-
-
Pituitary Adenylate Cyclase Activating Polypeptide: A Potential Neuroprotective Peptide
Authors: Aniko Somogyvari-Vigh and Dora ReglodiPituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from hypothalamic extracts on the basis of its ability to stimulate cAMP formation in pituitary cells. PACAP is widely distributed in the central and peripheral nervous systems and exerts numerous effects. Currently available data indicate that PACAP is a promising neuroprotective peptide. PACAP plays an important role during the development of the Read More
-
-
-
Antimicrobial Peptides: Mediators of Innate Immunity as Templates for the Development of Novel Anti-Infective and Immune Therapeutics
Authors: P. S. Hiemstra, B. A. Fernie-King, J. McMichael, P. J. Lachmann and J.- M. SallenaveAntimicrobial molecules are ancient and essential small cationic molecules of the host defence system which are found in a wide variety of species. They display antimicrobial activity against a wide range of bacteria, fungi and viruses, an activity that has been mostly attributed to the disruption of microbial membranes. In this article, we will review the “classical” functions of 3 classes of antimicrobial molecules, namely defensins Read More
-
Volumes & issues
-
Volume 31 (2025)
-
Volume 30 (2024)
-
Volume 29 (2023)
-
Volume 28 (2022)
-
Volume 27 (2021)
-
Volume 26 (2020)
-
Volume 25 (2019)
-
Volume 24 (2018)
-
Volume 23 (2017)
-
Volume 22 (2016)
-
Volume 21 (2015)
-
Volume 20 (2014)
-
Volume 19 (2013)
-
Volume 18 (2012)
-
Volume 17 (2011)
-
Volume 16 (2010)
-
Volume 15 (2009)
-
Volume 14 (2008)
-
Volume 13 (2007)
-
Volume 12 (2006)
-
Volume 11 (2005)
-
Volume 10 (2004)
-
Volume 9 (2003)
-
Volume 8 (2002)
-
Volume 7 (2001)
-
Volume 6 (2000)
Most Read This Month
Article
content/journals/cpd
Journal
10
5
false
en
