Current Pharmaceutical Biotechnology - Volume 24, Issue 5, 2023

The domoic acid (DA) produced by certain species of the marine pennate diatom genus Pseudo-nitzschia is highly neurotoxic and can induce nerve excitability and neurotoxicity by binding with ionotropic glutamate receptors, causing amnesic shellfish poisoning in humans who consume seafood contaminated with DA. In recent years, poisoning of humans caused by DA has occurred around the world, which has attracted increasi Read More

Hepatitis, an inflammation of the liver parenchyma, is a viral disease. Addressing the challenges of hepatitis is very important. Therefore, using nanoparticles (NPs) in solving the problems of hepatitis diagnosis and treatment can be considered a promising approach. To the best of our knowledge, there are few studies to review the most widely used and effective NPs in the field of hepatitis. A literature review was perfo Read More

Background: Non-alcoholic fatty liver disease (NAFLD) is now considered the most common chronic liver disease worldwide. NAFLD is related to changes in lipid metabolism and is characterized by the increase or accumulation of fat in hepatocytes that may progress to nonalcoholic steatohepatitis (NASH), which leads to the appearance of inflammatory processes. Treatment consists of changes in diet, physical activit Read More

Helicobacter pylori infection is a common health problem, which can cause gastric and extragastric diseases. Accurate detection of H. pylori is critical for appropriate patient management and bacterial eradication. In this regard, there are several methods for the diagnosis of H. pylori infection, which are classically divided into two major groups of invasive and non-invasive methods. Invasive methods, such as endoscop Read More

Plant lectins are carbohydrate-binding proteins that are ubiquitously found in almost all plant species and have different structures and functions depending on the sources. Purifying lectins from their plant sources and determining their sugar specificity become an important goal for evaluating their potential biomedical applications. Here, we report the affinity purification of a Dgalactose specific lectin from the seeds Read More

Background: Dysregulated Yes-associated protein 1 (YAP1) is closely associated with cancer progression and chemo-resistance. We aim to explore the role of YAP1/Hippo pathway in regulating doxorubicin (ADM)-resistance in acute myeloid leukemia (AML). Methods: In this study, we established two ADM-resistant cell lines (THP-1/ADM and K562/ ADM). Then, cell viability and apoptosis were detected by MTT assay and FCM assay, Read More

Background: Glioblastoma multiforme (GBM) is a heterogeneous and highly vascularized brain tumor that avoids apoptosis due to P-glycoprotein (P-gp) mediated multidrug resistance. Therefore, the development of new therapeutic strategies that induce apoptosis and inhibit proliferation is urgently warranted. Objectives: We examined the efficacy of the combination of baicalin (BAI) and knockdown of miR-148a gene in hum Read More

Introduction: The marine ecosystem contains many microbial species that produce unique, biologically active secondary metabolites with complex chemical structures. We aimed to isolate and identify bioactive compounds with antimicrobial properties produced by a facultative anaerobic strain of Bacillus subtilis (AU-RM-1), isolated from marine sediment. Methodology: We optimized the AU-RM-1 growth conditions, analyzed its gr Read More

Background: Gastric cancer (GC) is the most aggressive malignant tumor with limited treatment alternatives post metastasis. Vernodalin (VN) induced apoptosis has been reported in various types of human cancer cells. However, the precise molecular mechanisms underlying the anti-metastasis action of VN on GC cells are yet to be elucidated. Objective: In this study, we investigated the anti-metastatic and apoptotic e Read More