Current Pharmaceutical Biotechnology - Volume 24, Issue 12, 2023

Vesicular delivery systems are a kind of drug delivery system that is gaining popularity due to its sustained release nature. This article was designed to understand the characteristics of a drug carrier called multivesicular liposomes, which have the potential to be the future of sustainedrelease drug delivery systems. Multivesicular liposomes have a honeycomb-like structure made up of non-concentric aqueous polyhedral compa Read More

Background: Esophageal cancer (EC), including esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), is a highly prevalent malignancy that occurs predominantly in the Asian region and is related to ethnicity, genetics, diet, and lifestyle. The nuclear receptor (NR) superfamily consists of 48 members of the human body. It is a collection of a large class of transcription factors, including Peroxiso Read More

Background: Preclinical and clinical evidence implies that destructive therapies in local and malignant tissue are frequently used on patients with head and neck cancer. Consequently, the microbiome of the treated and adjacent regions is affected. Disruption of the normal microbiome plays an important role not only in the disease progression but also in its emergence, therefore new therapies involving probiotics, prebiotics, Read More

The severe respiratory infections in the current pandemic coronavirus disease-19 (COVID-19) have influenced more or less every human life. The first person to get infected with this virus was reported in the capital of Hubei province (Wuhan), China, in late December 2019. Since the disease has been declared a pandemic, research scholars and experts have been manufacturing new vaccines or targeted therapies to curb the Read More

Background: Knema (the Myristicaceae family) is a large genus of small-medium trees found in Southeast Asia, Africa, and Australia. Historical records dealt with the uses of Knema species as medicinal plants against various diseases, especially cancer remedies, or their application as tonic agents in Asian communities Objective: The aim of this review is to provide the most current knowledge on the traditional uses, chemica Read More

Colorectal cancer (CRC) is considered a lethal cancer all around the world, and its incidence has been reported to be increasing. Chemotherapeutic drugs commonly used for treating this cancer have shown some drawbacks, including toxicity to healthy cells and non-precise delivery. Thus, there is a necessity for discovering novel diagnostic and therapeutic options to increase the survival rate of CRC patients. Chitosan, as a natur Read More

Background: Alzheimer’s disease (AD) is an age-related neurodegenerative disease and is featured by cognitive impairment. Procyanidins have been shown to have a potential protective effect against neurodegenerative diseases, but the underlying mechanism is not comprehensive enough. Objective: To further investigate the effects of procyanidins from lotus seedpod (LSPC) on cognition in AD. Methods: The APP/PS1 transg Read More

Background: Rhizopus delemar, the main causative pathogen for the lethal mucormycosis and a severe threat during the COVID-19 pandemic, is resistant to most antifungals, including fluconazole, a known selective antifungal drug. On the other hand, antifungals are known to enhance fungal melanin synthesis. Rhizopus melanin plays an important role in fungal pathogenesis and in escaping the human defense mechanism, thu Read More

Aims: We linked phenotypes and genotypes by PheGe-Net, a unified operation frame. Background: Genotype refers to the general name of all gene combinations of an individual. It reflects the genetic composition of organisms. Phenotype refers to the macroscopic characteristics of an organism that can be observed. Objective: Identifying the phenotype-genotype association assists in the explanation of the pathogenesis and the Read More

Objectives: The nuclear factor-ΚB (NF-ΚB) signaling pathway plays an important role in regulating tubular epithelial-mesenchymal transition (EMT), an indispensable cellular programme for driving organ fibrosis and tumor progression. Liuwei Dihuang Decoction (LWD) is an effective Chinese formula for treating chronic renal failure. Methods: First, by using morphological examination, immunofluorescence staining assay, RTqP Read More