Current Proteomics - Volume 19, Issue 4, 2022

Background: Picrophilus torridus is a thermoacidophilic archaeon that thrives in an extremely low pH (0-1) and high temperatures (50-60°C). Thus, it is a suitable organism to study microbial genetics and metabolic adaptations to the extremely acidic and moderate thermal environment. Objective: In the present study we have conducted a global proteome analysis of P. torridus and discerned the cytosolic proteome of P. t Read More

Objective: Meat is biochemically active. Various pre-and post-harvest processes affect meat quality. Metabolomics is a valuable tool to elucidate metabolite changes in meat. The overall goal of this mini-review was to provide an overview of various techniques, data analysis, and application of metabolomics in meat color research. Results: Both targeted and non-targeted approaches are used to determine metabolite profiles in Read More

Background: Spider venom show abundant diversity in both peptides and proteins, which play essential roles in new drug development and agrochemistry. The venoms of Macrothele yani species have strong toxicity on the victims. Objective: The purpose of this study is to comprehensively characterize the profile of venom proteins and peptides of spider Macrothele yani mainly inhabiting Yunnan province, Read More

Background: With the development of medicine and technological advancement, the concept of precision medicine is becoming popular, and the traditional principle of all-in-one therapy has been gradually fading. Utilizing the detection of genome, transcriptome, proteome, and metabolome, combined with big data analysis to discover new pathogenic mechanisms, provides more effective prescriptions with fewer side effects Read More

Background: Protein function is closely related to its location within the cell. Determination of protein subcellular location is helpful in uncovering its functions. However, traditional biological experiments to determine the subcellular location are of high cost and low efficiency, which cannot meet today’s needs. In recent years, many computational models have been set up to identify the subcellular location of proteins. Most model Read More

Background: Severe acute respiratory syndrome (SARS-CoV-2), a zoonotic virus, is the pathogenic causal agent for the ongoing pandemic. Despite the lethality of the disease, there are no therapeutic agents available to combat the disease outbreak, and the vaccines currently accessible are insufficient to control the widespread, fast-mutating virus infection. Objective: This research study focuses on determining potential epit Read More