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Volume 6, Issue 1
  • ISSN: 2666-7967
  • E-ISSN: 2666-7975

Abstract

Background and Objective

Thinqure20 is a polyherbal, reverse-pharmacology-based formulation that contains , and rock salt as active ingredients. It is designed to work as an effective antiviral agent and also as a preventive measure against SARS-CoV-2. Clinical and non-clinical studies have established significant safety efficacy and tolerability of Thinqure20 formulation in the treatment of COVID-19 infection.

Methods

human study was conducted on COVID-19 patients for 5 days. A total of 30 Covid-19 patients (n = 30) were enrolled. , cell line studies were also carried out to evaluate the potential effectiveness of Thinqure20 polyherbal formulation as an antiviral, antifungal, and Angiotensin-Converting Enzyme 2 (ACE2) inhibition.

Results

Human studies have demonstrated mean percentage of reduction in viral load from baseline to end of the study visit was found to be 75.4%. The minimum and maximum reduction in viral load was found to be 59.3% and 99% respectively. Viral load testing was carried out by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) test. studies of Thinqure, 20 extracts showed potential antiviral activity against MS2 bacteriophage, influenza, and human coronavirus, antifungal activity against Mucor racemosus, and significant ACE2 receptor inhibition.

Conclusion

Thinqure20, a polyherbal formulation, is a potentially effective antiviral agent against non-enveloped viruses (MS2 bacteriophage), enveloped viruses (influenza and human coronavirus), and antifungal agent against strains. It is also proven to be effective in the treatment of COVID-19 and can be attributed to an early recovery by the reduction in viral load.

Clinical Trail Registration Number

CTRI/2021/03/032471.

© 2025 Bentham Science Publishers
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2024-03-13
2025-01-04

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/content/journals/covid/10.2174/0126667975283266240304095915
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Clinical Trial to Evaluate Safety and Efficacy of Thinqure20 (A Herbal Composition) in the Treatment and Prophylaxis of Novel Coronavirus and Testing its In vitro- Potential against MS2 Bacteriophagae, Corona Virus, Influenza Virus and Mucor racemosus
Coronaviruses 6, E130324227963 (2025); https://doi.org/10.2174/0126667975283266240304095915
/content/journals/covid/10.2174/0126667975283266240304095915
/content/journals/covid/10.2174/0126667975283266240304095915
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  • Article Type:     Research Article
Keyword(s): ACE 2 inhibition; ayurvedic formulation; COVID; herbal formulation; Thinqure20; viral load
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