Current Organic Synthesis - Volume 2, Issue 4, 2005

Room Temperature Ionic Liquids (RTILs) have recently been introduced as new solvents in the chemical and biotechnological arenas. Carbohydrates are important natural products that play important biological and commercial roles as foods, drugs and chemical feedstocks. They have two properties that complicate their use a low solubility in most solvents and complex, highly chiral structures. We are currently witnessing a Read More

this review focuses on the regio- and stereoselective synthesis of β-, γ-, and δ-aminophosphonic derivatives by combining dienophiles and dienes substituted by phosphono- and amino-groups. The initially formed cyclohexene adducts have been further transformed: chemoselective deprotections of masked P, C, and N functions, double bond oxidation and cleavage. Our Diels-Alder strategy has been successfully appli Read More

The stereoselective allylation of imines and related compounds is one of the most effective methods for the introduction of an amino group into carbon skeletons. Moreover, by extending the process to other C=N functionalities such as oximes, hydrazones, nitrones and iminium ions, a variety of nitrogen-containing functional groups can be prepared with the concomitant introduction of the allyl moiety. In several instances it is Read More

2-Amino-2'-hydroxy-1,1'-binaphthyl (NOBIN, 3) can be considered as the analogue of 1,1'-bi-2- naphthol (BINOL, 1) and 1,1'-bi-2-naphthylamine (BINAM, 2) in terms of its functionality and scaffold. Since the first report on the synthesis of NOBIN by Kocovsky, the chemistry of NOBIN has been developed rapidly in the last decade. This article summarizes its synthesis, modification and application of its derivatives as the chiral lig Read More

This review introduces the broad general topic of asymmetric organic synthetic reactions and reagents. Reagents containing both frequently used metallic ions, e.g. Zn++, Cu+(++) and Ru++, and rarely used ions, such as Ag+, employed in the construction of designed chiral centers, are updated here. Enantioselective 1,2-additions and 1,4-conjugate additions, transfer hydrogenations, and diasteroselective aldol reaction Read More