Current Organic Synthesis - Volume 19, Issue 4, 2022

A convenient, efficient, and general procedure for the synthesis of diaryl diselenides has been developed by the reaction of aryl diazonium tetrafluoroborates and potassium selenocyanate on the surface of alumina under ball-milling in the absence of any solvent, transition metal catalyst, and base in room temperature. A wide range of functionalized diaryl diselenides are obtained in high purity and high yield by th Read More

The investigation of the procedures for the multi-component synthesis of heterocycles has attracted the interest of organic and medicinal chemists. The use of heterogeneous catalysts, especially transition metal catalysts in organic synthesis, can provide a new, improved alternative to traditional methods in modern synthetic chemistry. The main focus is on the utilization of silver as a catalyst for the multi-component synthesis of h Read More

Background: Tubulysins, linear tetrapeptides, show extraordinary cytotoxicity against various cancer cells, with IC50 values in the nano or picomolar range. Due to their extremely vigorous anti-proliferative and antiangiogenic characteristics, tubulysins exhibit captivating prospects in the development of anticancer drugs. This review focuses on diverse routes for the total synthesis of natural and synthetic tubulysins as well Read More

Constituted by ions, ionic liquids (ILs) are evolving as greener solvents for many organic syntheses. Due to their high solvent power and low volatility, ionic liquids are serving as an environment- friendly substitute to conventional volatile organic solvents. The present review introduces ionic liquids as an insight into the diverse recent applications of ILs in organic synthesis.

Background: A series of new pyrimidines and thiazoles containing camphor moiety were synthesized under both conventional and microwave irradiation techniques. Methods: The condensation of camphor either with aminoguanidine or thiosemicarbazide gives the camphor hydrazine carboximidiamide 2 and the camphor thiosemicarbazone 3, respectively. Refluxing of 3 with chloroacetonitrile afforded the camphor thi Read More