Current Organic Synthesis - Volume 18, Issue 6, 2021

This review article summarizes the applications of nickel(II) compounds in organic synthesis since 2016. In recent years, the field of nickel(II) catalysis is gaining considerable interest due to readily available, low-cost nickel(II)-compounds and several key properties of nickel. This review article is organized by the reaction type, although some reactions can be placed in multiple sections.

The subclass of compounds that have the nucleus 1, 4-naphthoquinone is the most diverse class of quinones, which have a large number of substances and have useful applications ranging from medicinal chemistry to application in materials with special properties. The introduction of one or two substituents with the sulfur heteroatom in the naphthoquinone nucleus generates products containing alkyl and aryl groups t Read More

Pyrazolopyrimidines are a privileged class of 5-6 bicyclic systems with three or four nitrogen atoms, including four possible isomeric structures. The significance of this class of compounds is that they can be applied in medical and pharmaceutical fields due to their unlimited biological aptitude, hence it is the basic skeleton of several synthetic drugs. The current review aimed to highlight all the synthetic routes that have been ap Read More

Background: Paclitaxel, a natural diterpenoid compound, has anti-tumor effect by acting on tubulin, whereas coumarin, another kind of natural product, has anti-tumor effect, along with some other effects, such as anti-bacterial-., Moreover, it also possesses fluorescence. Objective: Multi targeting is an effective strategy in drug design to combat tumor. Therefore, a combination of paclitaxel with other active molecular dru Read More

Aims: The aim of the present research was to synthesize glycoluril derivative 2,4-Bis(4- cyanobenzyl)glycoluril through a convergent scheme. Background: For this purpose, Sandmeyer reaction procedure was employed for the synthesis of said compound. The structure of the pure compound was confirmed by using different spectroscopic techniques, such as 1HNMR, 13C-NMR and (HR-MS) Mass spectrometry. Objec Read More

Aims and Objective: The main objective of the kinetic investigation of the reaction between ethyl acetoacetate 1, ammoniumacetat 2, dimedone 3, and diverse substitutions of benzaldehyde 4-X, (X= H, NO2, CN, CF3, Cl, CH (CH3)2, CH3, OCH3, OCH3, and OH) for generating 4-substituted 1, 4-dihydropyridine derivatives (product 5) was to recognize the most realistic reaction mechanism. The layout of the reaction mechanism Read More