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2000
Volume 18, Issue 6
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Background: Paclitaxel, a natural diterpenoid compound, has anti-tumor effect by acting on tubulin, whereas coumarin, another kind of natural product, has anti-tumor effect, along with some other effects, such as anti-bacterial-., Moreover, it also possesses fluorescence. Objective: Multi targeting is an effective strategy in drug design to combat tumor. Therefore, a combination of paclitaxel with other active molecular drugs for exploring the novel lead with multi-functions is in demand. Materials and Methods: To synthsize paclitaxel-coumarin conjugate via click chemistry and to investigate anticancer activity by MTT assay and the scratch test. Results and Discussion: The results of MTT assay showed that compared tothe paclitaxel, the anti-tumor activity of the conjugate was significantly improved. The results of flow cytometry showed that the conjugate had a stronger ability to induce apoptosis. The scratch test results showed that the conjugate had better anti- metastasis ability than paclitaxel. Conclusion: These findings indicated that paclitaxel and coumarin had a synergistic effect, which paved the way for the development of paclitaxel through fluorescence.

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/content/journals/cos/10.2174/1570179418666210303113406
2021-09-01
2025-07-10
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/content/journals/cos/10.2174/1570179418666210303113406
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  • Article Type:
    Research Article
Keyword(s): anti-metastasis; anti-tumor activity; conjugate; coumarin; Paclitaxel; synthesis
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