Current Organic Synthesis - Volume 10, Issue 4, 2013

The last decade has been characterized by an extraordinary development of glycochemistry. Availability of synthetic glycoconjugates is, therefore, becoming more and more crucial to disclose the structural and functional aspects of glycoconjugates naturally present in cells and living organisms. Modern carbohydrate chemistry is engaged in the challenging task of providing more efficient methods to deliver pure well-defined oligo Read More

The photo physical characterization of synthetic amino acids with side chain chromophoric systems has particular importance as fluorescent probes for extending our understanding of protein folding, stabilization and various fields of biological research. Chemists are now designing bio mimetic chromophore based amino acids that have characteristic spectral properties, which change significantly after formation of secondary a Read More

α-Amino acids play vital roles in protein and synthetic chemistries. Access to those molecules has been an intensive focus of research in recent years, and new methods are continuously being explored. The present review gives an overview of syntheses of α- amino acids based on glycine equivalents.

The literature on the syntheses of amido-, carbamido- and carbamatoalkylnaphthol derivatives is reviewed. With regard to the appreciable number of publications (over 110) that have appeared in the past 6 years, the various reactions are classified according to the types of nitrogen sources used (nitriles, amides, thioamide, ureas, thioureas or carbamates).

The synthesis of substituted norbornadienes has drawn a significant amount of interest as they possess a great deal of synthetic utility. Although substituted norbornadienes have typically been synthesized through Diels-Alder [4+2] cycloaddition methods, several other methods have been developed to synthesize various substituted norbornadienes. The purpose of this review is to discuss the many methods that have been Read More

1,2-Diaza-1,3-dienes bearing electron-withdrawing groups react with electron-poor alkenes by means of an uncommon aza- Diels-Alder reaction furnishing novel tetrahydropyridazines with high regio- and stereoselectivity. Conducting these cycloadditions in solvent free conditions under thermal conditions the reaction times are significantly reduced, the yields are improved and the stereoselectivity remained unchanged.

Ibandronate and Alendronate/Alendronic acid were prepared by the reaction of the corresponding amino acids (N-methyl-Npentylalanine and γ-aminobutyric acid) with 3.2 equivalents of phosphorus trichloride, in the absence of any phosphorous acid, in methanesulfonic acid at 75 °C for 12 h followed by hydrolysis, pH adjustment and purification. The first intermediate of the reaction sequence is the corresponding chloride (> Read More

An efficient method for the synthesis of pyridines related to nicotinic acid and their fused derivatives is described. The overall process involves a sequence comprising a four-component reaction that creates the heterocyclic framework from very simple open-chain precursors and two elimination steps, that are performed without the need for purifying any intermediate.

An efficient and one-pot synthesis of 2,4,6-triarylpyridines by palladium-catalyzed cyclocondensation of benzaldehydes, terminal aromatic alkynes and ammonium bifluoride in the presence of tert-butyl peroxide (TBP) as oxidant is developed.