Current Organic Synthesis - Volume 10, Issue 2, 2013

Stereocontrolled formation of C-C bonds in polyfunctionalized carbohydrate derivatives, which are crucial synthetic intermediates, is sometimes very challenging. The application of low valent organometallic reagents for C-C bond formation in carbohydrate chemistry has recently attracted a great deal of attention, largely due to the mild reaction conditions required. We present here an overview of the application of different Read More

2'-Deoxy-methanocarba nucleosides are a class of compounds with important antiviral and antitumor activities. (N)-2'-deoxymethanocarbathymidine, (N)-MCT, is known as active and specific agent against herpes simplex viruses (HSV1 and 2) and Kaposi's sarcoma- associated herpes virus (KSHV). Some analogues such MRS2500 and MRS2279 have potent antithrombotic therapeutic effect due to thei Read More

Amide is the key functional group in organic and biological chemistry as it is present in many natural products of therapeutic importance, peptides and polymers. There is continuous exploration of methodologies that can facilitate the user to choose the method of its interest regarding the availability of substrates and high atom economy. In this review, the catalytic methods developed in the past decade mainly focusing on Read More

In this review article we have gathered relatively recent publications involving modern methodologies for iodination reactions of aromatic and heteroaromatic compounds using pure water or mixtures containing water as environmentally friendly media.

Tandem or sequential processes involving the Wittig reaction have been extensively used over the past decade in light of their potential in organic synthesis for the construction of complex molecules from simple precursor in a single process. This review is centered on the use of one-pot processes involving Wittig as the core reaction for the synthesis of highly functionalized and biologically important compounds and also f Read More

Novel, symmetrically distributed bisphenol A glycerolate dimethacrylate cross-linked polystyrene support (PS-BGD) for solid phase organic synthesis is presented here. PS-BGD support was synthesized in various mole densities of BGD by suspension copolymerization method. The swelling nature of PS-BGD in various polar/non-polar media was tested and used to compare with commercially available Merrifield, TentaGel and CLEAR Read More

A simple and efficient synthesis of isoquinoline derivatives by the condensation of ortho-alkynyl aromatic aldehydes/ketones with urea in the presence of copper salts is developed.

Hydrochloric acid activated bentonite was used as a catalyst for hydroamination of cyclohexene with p-toluenesulfonamide under atmospheric pressure. The structure and surface acid property of the catalyst were studied by XRD and NH3-TPD. The effects of acid treatment condition and solvent on the yield of N-cyclohexyl-p-toluenesulfonamide were specifically studied. It was found that apolar aprotic solvents were the su Read More