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Volume 22, Issue 1
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Background

Condensation of 3-acetyl coumarin with 2‐(4-methoxy- benzylidene)malononitrile in ammonium acetate/acetic acid or absolute ethanol/piperidine affords pyridine and chromen-2-one derivatives, respectively.

Methods

In this study, the reaction of with an electrophilic reagent, namely, formic acid, acetic anhydride and formamide afforded the pyridopyrimidinone and pyridine derivatives . Also, treatment of with different aromatic aldehydes, carbon disulfide, NaN/NHCl, 2-(4-methoxybenzylidene)malononitrile and acetophenone afforded pyridopyrimidinone, carbamodithioic acid, tetrazol-5-yl-chromen-2-one, 2H-chromen-2-one, and pyridine derivatives , respectively.

Results

This study synthesized coumarins with antimicrobial activity and verified the structure and purity of the synthesized compounds using spectral data.

Conclusion

The new compounds were evaluated for their antimicrobial activity against gram-positive bacteria (, and gram-negative bacteria (, d), in addition to fungus (). The investigated substances and presented good activity against , and , while compounds and exhibited good to moderate activity.

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2024-04-03
2025-05-10

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Heteroaromatization of Coumarin Part II: Synthesis, Reactions, and Antimicrobial Activities of Novel Pyrido[2,3-d]pyrimidine Derivatives
Curr. Org. Synth. 22, 108 (2025); https://doi.org/10.2174/0115701794290718240322054346
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  • Article Type:     Research Article
Keyword(s): 3-acetyl coumarin; antimicrobial activities; condensation; pyridine; pyridopyrimidinone; Schiff base

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