Current Organocatalysis - Volume 11, Issue 1, 2024

Introduction: Resiquimod (formula C17H22N4O2, ChEMBL Id 383322) is an immune response modifier that stimulates immune responses to tumor lesions mostly through toll-like receptors (TLR) 7 and 8 dependent pathways. Methods: This study considers the potential use of Resiquimod in the topical treatment of mycosis fungoides tumor stage, for which standard-of-care is radiation therapy which has a very wellknown dosage Read More

Background: Benzimidazole is a remarkable heterocyclic chemical compound in which the phenyl ring is fused with the imidazole ring at positions 4 and 5. Benzimidazole derivatives have lots of medicinal activity in the pharmaceutical industry. Therefore, the synthesis of benzimidazole derivatives is challenging in this scientific field. Methods: In benzimidazole synthesis, simple nucleophilic substitution and condensation re Read More

We easily synthesized two ionic liquids, [BMIM][OH] and [BPy][OH], with high yield. We found that hydrotalcite clay, mediated by these ionic liquids, is a highly effective catalyst for synthesizing biologically active 1,2-dihydroquinazoline derivatives. Using a simple reaction protocol and easy product isolation steps, we successfully synthesized 18 different 1,2-dihydroquinazoline derivatives and were able to recycle the catalyst Read More

Aims: Understanding nucleophilicity of poor nucleophiles like pyridine-N-oxides. Background: Nucleophilicity plays a vital role in substitution reactions. It helps to determine the possibility and extent of the substitution reactions. The study of the nucleophilicity of poor nucleophiles is challenging, and it has limited substrate scope. Understanding the strength of nucleophilicity of such poor nucleophiles in a quantitative Read More

Aim: Computational Quantum and Spectroscopic analysis of 4-Hydroxy-1-Naphthaldehyde Background: Known also as 4-Hydroxynaphthalene-1-carbaldehyde, 4-hydroxy-1-naphthaldehyde (4H1NA) is a crucial precursor of many coordinating agents. A commercial compound called 4- hydroxy-1-naphthaldehyde (4H1NA) can be used to make a number of different sensors. In the development of many chemosensors, th Read More

Introduction: Pharmaceutical research currently focuses on methods that allow for more sustainable and natural approaches. In this way, the use of discarded by-products, such as avocado seed, becomes a profitable and sustainable practice. Methods: This study evaluated the extraction of phytochemicals from avocado seed (Soxhlet extraction) and compared the antioxidant capacity of avocado seed (DPPH method). The e Read More

Background: Catechol is a phenolic molecule found naturally in plants. It is also known as pyrogallic acid or 1, 2-dihydroxybenzene. Catechol is currently produced commercially by decarboxylating gallic acid at high temperatures and pressures. Aims and Objectives: This research aimed to understand the biological importance of catechol and perform molecular structural analysis on catechol molecules. Methods: Catechol ( Read More