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Volume 12, Issue 1
  • ISSN: 2213-3372
  • E-ISSN: 2213-3380

Abstract

Background

Biotransformation is a powerful process for producing steroid compounds, and fungi are commonly regarded as effective biological agents for this purpose. They facilitate reactions that are difficult to perform conventional chemical methods.

Objective

In the current study, the ability of to biotransform progesterone was studied.

Methods

Forty-eight hours after the incubation of active with substrate (progesterone), the reaction medium was extracted and chromatography methods isolated metabolites. The chemical structures of the products were characterized by various spectroscopic techniques.

Results

Two main hydroxylated products, 14α-hydroxyprogesterone, and 7α,14α-dihydroxyprogesterone, were finally identified.

Conclusion

may be considered a functional biocatalyst for some biotransformation processes.

© 2025 Bentham Science Publishers
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2024-09-09
2025-06-21

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Biocatalytic Hydroxylation of Progesterone by Penicillium aculeatum
Curr. Organocatal. 12, 70 (2025); https://doi.org/10.2174/0122133372334969240902092741
/content/journals/cocat/10.2174/0122133372334969240902092741
/content/journals/cocat/10.2174/0122133372334969240902092741
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  • Article Type:     Research Article
Keyword(s): 14α-hydroxyprogesterone; 7α,14α-dihydroxyprogesterone; Biohydroxylation; biotransformation; Penicillium aculeatum; progesterone

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