Current Organic Chemistry - Volume 4, Issue 5, 2000

Recent applications of the naked sugar methodology are reviewed. General methods have been developed to transform enantiomerically pure 7-oxabicyclo­(2.2.1)heptyl derivatives into rare monosaccharides, carbasugars, into a new doubly-branched imino-dideoxyalditol (iminosugar), into long-chain carbohydrates, C-disaccharides, imino-C-disaccharides and new polyhydroxylated quinolizidines. The methods allow to prepar Read More

Glycobiology is a rapidly evolving field and tackles many phenomena of biomedical importance. Driven by the need to create more efficient methods for the synthesis of complex oligosaccharides, the last few years have seen a major push toward a general approach amenable to solid-phase synthesis. Different strategies have been explored and a host of glycosylating agents have been investigated. New linker systems, Read More

Many cellular events such as secretion or proliferation require activation of proteins by calcium ions. Intracellular calcium is mobilized by the formation of the second messenger D-myo-inositol 1,4,5-trisphosphate (InsP3) and subsequent binding to a receptor located on the endoplasmic reticulum. Pharmacological studies of these biological processes have stimulated the search for new ligands of the InsP3 receptor (InsP3 Read More

Microbial carbohydrate structures show a considerable complexity due to the presence of an immense variety in the integral substituents and monosaccharide residues, both regarding structure and position. This severely complicates both the analyses and syntheses of these compounds. This article discusses the synthetic preparation of structures containing some of these intricate structural features. The inner core regio Read More