Current Organic Chemistry - Volume 4, Issue 6, 2000

The synthetic potential of low molecular weight carbohydrates in the form of their hydrazones or bishydrazones as precursors for heterocyclic compounds and acyclic nucleosides, which could be degraded into functionalized heterocycles without polyol residues, is the subject of this review. The inherent functionalities in such hydrazone derivatives make them suitable for building the skeleton of heterocyclic compounds. This Read More

This account is devoted to a discussion of synthetic applications of olefin metathesis in carbohydrate chemistry.Olefin metathesis has emerged as a highly promising and exciting area in the contemporary organic synthesis of carbon-carbon bonds. Metathetic ring-closure (RCM) of diene precursors is advancing into one of the most useful and frequently applied transformations in modern organic chemistry. The developm Read More

Numerous methods for preparation of C-glycosylic compounds (C-glycosides) have been developed. One general approach to the synthesis of these important O-glycoside analogs is based on the use of three-membered cyclic intermediates. The review is focused on the application of glycal and exo-glycal derived epoxides and episulfonium and iodonium ions for preparation of C-glycosides. Reactions of glycal epoxides with o Read More

Vaccination is the most cost-efficient and the most powerful medical intervention in the control, prevention and eradication of many diseases that affect human population. Capsular polysaccharide based vaccines have been in use for many decades providing immunity against various bacterial infections. The advent of new efficient and sensitive analytical and synthetic methods in carbohydrate chemistry, together with our incre Read More