Current Organic Chemistry - Volume 4, Issue 1, 2000

Cells utilize myo-inositol for osmoregulation and phosphatidylinositol signaling. Mass spectrometric and in vivo magnetic resonance spectroscopic techniques have been complementarily used in our laboratories to investigate brain myo-inositol metabolism. Mass spectrometric quantitation methods are surveyed focusing primarily on derivatization reactions, gas chromatographic separation and detection of ions. Monitoring Read More

Isotope effects on chemical shifts of intramolecularly hydrogen bonded systems are reviewed. The effects are conveniently divided into localized (intrinsic) and equilibrium isotope effects. The review covers both primary and secondary isotope effects on chemical shifts. For the localized one it is very important to distinguish between RAHB and non-RAHB types. For the RAHB systems the OH group is shown to form a stronger hy Read More

Electron Spin Resonance (ESR) spectroscopy is the technique sine qua non for establishing the geometric and electronic structures of the free radicals participating in many organic reactions and syntheses. It also allows the mechanisms of the complex network of elementary reactions constituting the overall chemical change to be determined and the rate parameters of these reactions to be measured. Radicals can be Read More

Nuclear Magnetic Resonance (NMR) spectroscopy of molecules aligned in liquid crystalline media provides information on molecular structure and order parameters. The partial alignment of the molecules in the anisotropic phase of the liquid crystals gives rise to residual intramolecular dipolar couplings which are dependent on the internuclear distances and therefore yield information on the geometry of molecules. The spectr Read More