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- Volume 7, Issue 1, 2007
Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Central Nervous System Agents) - Volume 7, Issue 1, 2007
Volume 7, Issue 1, 2007
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Metabotropic Glutamate Receptors Modulate Periaqueductal Grey Descending Analgesic System
Authors: E. Palazzo, V. de Novellis, I. Marabese, F. Rossi and S. MaioneMetabotropic glutamate receptors (mGluRs) are a family of G-protein-coupled receptors which play an important role in the modulation of nociception transmission and plasticity [1,2]. In this review we will consider the control of supraspinal nociception by mGluR ligands in several animal models of pain through behavioural and biochemical approaches. More specifically, we will focus our attention on the mGluRs of Read More
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Pathophysiology of Status Epilepticus Induced by Pilocarpine
Status epilepticus (SE) is clinically defined as prolonged electrical and clinical seizure activity in which the patient does not regain consciousness to a normal alert state between repeated tonic-clonic attacks. The disorder is a neurological emergency associated with a mortality rate of 10-12% and an even greater morbidity. SE can lead to permanent pathological damage and altered physiological function in certain brain regions an Read More
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Neuromodulation of Hippocampal Synaptic Plasticity, Learning, and Memory by Noradrenaline
Authors: J. N. Gelinas and P. V. NguyenNeuromodulators are chemical substances that modify neural responses without directly triggering synaptic excitation. They broadly impact multiple brain functions, such as arousal, sleep, attention, perception, learning, and memory. The noradrenergic neuromodulatory system widely innervates the mammalian brain, including the hippocampus. Hippocampal synaptic plasticity is believed to importantly contribute to the Read More
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Neurochemistry and Pharmacological Treatments: Where is the Field of Anorexia Nervosa Heading?
More LessAnorexia nervosa is a debilitating psychiatric disorder characterized by severe dietary restriction and lifethreatening weight loss. The onset of the disorder typically occurs during adolescence with 90-95% of all cases occurring in females. Often characterized by a chronic and relapsing course, anorexia nervosa has one of the highest mortality rates of any psychiatric disorder. Although the etiology is unknown, a complex interpl Read More
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Kynurenines in the Central Nervous System: Recent Developments
Authors: Hajnalka Nemeth, Hermina Robotka, Jozsef Toldi and Laszlo VecseiThe intermediates of the kynurenine pathway, called kynurenines, are derived directly or indirectly from the tryptophan metabolism. This metabolic pathway is responsible for nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, which participate in basic cellular processes. It was discovered some thirty years ago that kynurenines have neuroactive properties. Kynurenine, the central compound of Read More
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PET Tracers for Mapping Adenosine Receptors as Probes for Diagnosis of CNS Disorders
Authors: Kiichi Ishiwata, Yuichi Kimura, Erik F. J. de Vries and Philip H. ElsingaAdenosine is an endogenous modulator of several physiological functions in the central nervous system (CNS). The effect is mediated by a receptor family that consists of at least four subtypes: A1, A2A, A2B and A3 receptors. The adenosine receptors play a role in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, epilepsy and schizophrenia. Knowledge on adenosine receptor densities and Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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