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Abstract

Background

An antibiotic called doxorubicin is produced by the bacterium, which is a member of the anthracycline drug class and is used in chemotherapy. Usually, doxorubicin is employed to cure solid tumors in children and adult patients. The physical and biological stability of the medicine can be increased by encasing it in nanoparticles, which increases the active pharmaceutical ingredient's bioavailability.

Objective

This study aimed to create lungs targeting doxorubicin-loaded biodegradable polymeric nanoparticulate system by utilizing an appropriate method and conducting its evaluation.

Methods

The polymeric nanoparticles using biodegradable polymers were prepared by the emulsion polymerization method. Franz- diffusion cells were utilized to conduct drug diffusion investigations.

Results

Based on the outcomes of the experiments carried out for the research, polymeric nanoparticles of doxorubicin were prepared utilizing different concentrations of chitosan, Sodium alginate, and PLGA. The visual appearance of doxorubicin polymeric nanoparticles shows homogeneous dispersion with no phase separation form. The percentage yield, % entrapment efficiency, and drug content obtained for the final formulation were 93.43 ± 1.776, 87.31 ± 1.075, and 91.98 ± 0.493, respectively. A size dimension of 174.51 nm with a PDI of 0.242 and zeta potential value of -36.1 mV of prepared nanoparticles demonstrate the stability of the formulation. The presentation of the PNPs of the optimized formulation having 310mg Tween 80 showed diffusion of 98.93% ± 0.296% and an increased flux rate. Based on the determination coefficients, the Higuchi model (K = 20.43 and R2= 0.982) was determined to have the best fit for the release data.

Conclusion

Based on the trials conducted during the investigation, it was determined that the emulsion polymerization technique was best for the fabrication of the polymeric nanoparticles by utilizing different concentrations of chitosan, Sodium alginate, and PLGA. The formulation F6 containing 310mg Tween 80 suggested improved diffusion following the Higuchi model throughout all formulations. The findings suggest that a sustained process was responsible for the drug's release from the doxorubicin polymeric nanoparticles.

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2024-09-27
2024-11-23

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/content/journals/cnanom/10.2174/0124681873310972240918091434
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Formulation and Evaluation of Lungs-Specific Doxorubicin-Loaded Chitosan-PLGA-Alginate Polymeric Nanoparticles
Bentham Science Publishers ; https://doi.org/10.2174/0124681873310972240918091434
/content/journals/cnanom/10.2174/0124681873310972240918091434
/content/journals/cnanom/10.2174/0124681873310972240918091434
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  • Article Type:     Research Article
Keywords: correlation coefficients ; Polymeric nanoparticles ; preformulation studies ; specific targeting ; standard curve

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