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image of Intracranial Structural Malformations in Children in Tibet: CT and MRI Findings in a Single Tertiary Center
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Abstract

Objectives:

The objective of this study was to summarize the findings of children’s intracranial congenital or developmental malformations found during imaging procedures in the Tibetan plateau.

Methods:

We retrospectively reviewed the imaging data of the suspected patients who presented with the central nervous system (CNS) malformations and were enrolled either through the clinic or after ultrasound examinations between June 2019 and June 2023 in our institution. All imaging data were interpreted by two experienced radiologists through consensus reading.

Results:

In this study, we recruited 36 patients, including two neonates, 17 infants and 17 children. Seven cases underwent an MRI examination, while the others had a CT scan. Polygyria and pachygyria malformation were the most common type of congenital neurological malformations (7 cases, 31.8%), followed by cystic changes of the cerebral parenchyma (3 cases, 13.6%). Cerebral atrophy was the most common type of secondary CNS abnormality(8 cases, 57.1%), followed by communicative hydrocephalus (3 cases, 21.4%). Five patients in the congenital group and 4 patients in the secondary group had complex malformations. In the current study group, there were 8 deaths, 12 cases with neurological sequelae, 1 case with normal development, and 15 cases lost to follow-up. There were no significant differences between the primary and secondary CNS groups in terms of the outcome for both the infants and children groups.

Conclusions:

CNS malformations in the Tibetan Plateau are associated with high mortality and morbidity rates. Better utilization of imaging modalities could help design tailored treatments as early as possible.

© 2024 The Author(s). Published by Bentham Science.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2025-01-02
2025-04-21

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References

  1. Huang JH Chen XL Xu SZ Yang XH The effect evaluation of standardized prenatal ultrasound screening was promoted for the first time in tibet autonomous region. Chin J Med Ultrasound 2020 17 05 457 462
    [Google Scholar]
  2. Huang J.H. Chen X.L. Xu S.Z. Yan Y.L. Yang X.H. Application of standardized prenatal ultrasound screening in the prenatal diagnosis of birth defects in the tibet autonomous region. Compilation of papers of the 7th National Obstetrics and Gynecology ultrasound Medicine Academic Conference of Chinese Society of Ultrasound Medical Engineering 2018
    [Google Scholar]
  3. Suolangzhuoma D. The current status of 322 Tibetan newborns with birth defects in Lhasa area. Tire Sci. Technol. 2018 9 36 40
    [Google Scholar]
  4. Lian G. Sheen V. Cerebral developmental disorders. Curr. Opin. Pediatr. 2006 18 6 614 620 10.1097/MOP.0b013e328010542d 17099359
    [Google Scholar]
  5. Wei W. Wang X. Gong Q. Fan M. Zhang J. Cortical thickness of native tibetans in the qinghai-tibetan plateau. AJNR Am. J. Neuroradiol. 2017 38 3 553 560 10.3174/ajnr.A5050 28104637
    [Google Scholar]
  6. Fayed N. Modrego P.J. Morales H. Evidence of brain damage after high-altitude climbing by means of magnetic resonance imaging. Am. J. Med. 2006 119 2 168.e1 168.e6 10.1016/j.amjmed.2005.07.062 16443427
    [Google Scholar]
  7. Perger E. Baillieul S. Esteve F. Pichon A. Bilo G. Soranna D. Doutreleau S. Savina Y. Ulliel-Roche M. Brugniaux J.V. Stauffer E. Oberholzer L. Howe C. Hannco I. Lombardi C. Tamisier R. Pepin J.L. Verges S. Parati G. Nocturnal hypoxemia, blood pressure, vascular status and chronic mountain sickness in the highest city in the world. Ann. Med. 2022 54 1 1884 1893 10.1080/07853890.2022.2091791 35786084
    [Google Scholar]
  8. Zhang X. Xie W. Liu Y. Li M. Lin J. Yin W. Yang L. Li P. Sun Y. Li T. Liu H. Ma H. Zhang J. Brain structural and functional alterations in native tibetans living at high altitude. Neuroscience 2023 520 134 143 10.1016/j.neuroscience.2023.01.019 36716913
    [Google Scholar]
  9. Baptiste C. Mellis R. Aggarwal V. Lord J. Eberhardt R. Kilby M.D. Maher E.R. Wapner R. Giordano J. Chitty L. Fetal central nervous system anomalies: When should we offer exome sequencing? Prenat. Diagn. 2022 42 6 736 743 10.1002/pd.6145 35411553
    [Google Scholar]
  10. Adle-Biassette J. A. Developmental and perinatal brain diseases. Handb Clin Neurol 2017 145 51 78 10.1016/B978‑0‑12‑802395‑2.00006‑7
    [Google Scholar]
  11. Barañano Burd I. CNS malformations in the newborn. Matern Health Neonatol Perinatol 2022 8 1 1
    [Google Scholar]
  12. Xiao H. Analysis of pre-pregnancy examination of pregnant couples and prenatal and prenatal education in the first district of Xizang Tibet. World's Latest Med. Inf. Abstract 2019 19 49 168 169
    [Google Scholar]
  13. Wang XP Birth defect monitoring report in the tibet autonomous region. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 1992 04 209 211
    [Google Scholar]
  14. Miller J.H. Bardo D.M.E. Cornejo P. Neonatal neuroimaging. Semin. Pediatr. Neurol. 2020 33 100796 10.1016/j.spen.2020.100796 32331611
    [Google Scholar]
  15. Pang T. Atefy R. Sheen V. Malformations of cortical development. Neurologist 2008 14 3 181 191 10.1097/NRL.0b013e31816606b9 18469675
    [Google Scholar]
  16. Barkovich A.J. Imaging of the newborn brain. Semin. Pediatr. Neurol. 2019 32 100766 10.1016/j.spen.2019.08.002 31813522
    [Google Scholar]
  17. Greicius M.D. Neuroimaging in developmental disorders. Curr. Opin. Neurol. 2003 16 2 143 146 10.1097/00019052‑200304000‑00004 12644740
    [Google Scholar]
  18. Specchio N. Curatolo P. Developmental and epileptic encephalopathies: What we do and do not know. Brain 2021 144 1 32 43 10.1093/brain/awaa371 33279965
    [Google Scholar]
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Intracranial Structural Malformations in Children in Tibet: CT and MRI Findings in a Single Tertiary Center
Bentham Science Publishers , e15734056321642; https://doi.org/10.2174/0115734056321642241213103658
/content/journals/cmir/10.2174/0115734056321642241213103658
/content/journals/cmir/10.2174/0115734056321642241213103658
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  • Article Type:     Research Article
Keywords: Central nervous system ; Newborn ; Infant ; Magnetic resonance imaging ; Computed tomography ; Abnormalities

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