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Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

Understanding brain changes in older patients with depression and their relationship with cognitive abilities may aid in the diagnosis of depression in this population. This study aimed to explore the association between brain lesions and cognitive performance in older patients with depression.

Methods

We utilized magnetic resonance imaging data from a previous study, which included older adults with and without depression. Smoothed Regional Homogeneity (ReHo) and local brain Amplitude of Low-frequency Fluctuation (ALFF) values were assessed to examine brain activity.

Results

The analysis revealed decreased ReHo in the left middle temporal gyrus, left middle frontal gyrus, and left precuneus, as well as increased local ALFF in the right middle occipital gyrus, left postcentral gyrus, and right precentral gyrus in older patients with depression. These alterations may contribute to behavioral and cognitive changes. However, no significant relationship was found between ReHo values and Montreal Cognitive Assessment (MoCA) scores. In contrast, increased local ALFF in the left postcentral gyrus and right precentral gyrus was negatively correlated with MoCA scores.

Conclusion

This study demonstrated a significant association between regional brain alterations in patients with depression and cognitive behavior. Thus, this work identified functional brain regions and cognitive performance in older adults with depression, highlighting specific brain regions that play a crucial role in cognitive abilities in this population.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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/content/journals/cmir/10.2174/0115734056281104241220113235
2025-01-01
2025-05-31

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/content/journals/cmir/10.2174/0115734056281104241220113235
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Magnetic Resonance Imaging Study on Older Patients with Cognitive Impairment and Depression
Curr. Med. Imaging 21, e15734056281104 (2025); https://doi.org/10.2174/0115734056281104241220113235
/content/journals/cmir/10.2174/0115734056281104241220113235
/content/journals/cmir/10.2174/0115734056281104241220113235
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  • Article Type:     Research Article
Keyword(s): Correlation analysis of cognitive ability; Depression; Difference analysis; Magnetic resonance imaging (MRI); Montreal cognitive assessment (MoCA); Older patients

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