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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

The neural mechanisms underlying Congenital Sensorineural Hearing Loss (CSNHL) remain elusive.

Objective

This study evaluated the function of the glymphatic system in children with CSNHL compared to normal-hearing children using the DTI-ALPS approach, which utilizes diffusion tensor imaging along the perivascular space.

Methods

Twenty-six children with CSNHL and 30 age- and sex-matched Healthy Controls (HCs) with normal hearing thresholds were recruited. The DTI-ALPS index was calculated for each group. We analyzed the discrepancies in the DTI-ALPS index between patients with CSNHL and healthy controls. Additionally, Spearman's correlation analysis was performed to investigate the relationship between the DTI-ALPS index and age in children with CSNHL.

Results

Significant differences in the DTI-ALPS index were observed between the two groups. Compared with HCs, the DTI-ALPS index in CSNHL patients was significantly lower (1.49388±0.11441 . 1.61402±0.15430, =0.002). In addition, diffusivity along the z-axis in the association fiber (Dzzassoc) index was significantly higher in the CSNHL group than in the HC group (0.00041±0.00006 . 0.00036±0.00004, =0.003). Furthermore, we discovered a noteworthy downward correlation between the DTI-ALPS index and age in children with CSNHL (rho = -0.544, =0.005).

Conclusion

In this present study, glymphatic system activity in CSNHL children was investigated for the first time using the DTI-ALPS index. A significant decrease in glymphatic system function was detected in CSNHL children, which correlated well with age. The DTI-ALPS index could serve as a valuable biomarker for tracking disease progression and treatment in CSNHL and unraveling the neural mechanisms of early hearing deprivation in children with CSNHL.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-06-30

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/content/journals/cmir/10.2174/0115734056305276240730113140
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Glymphatic System Dysfunction in Congenital Sensorineural Hearing Loss: A DTI-ALPS Study
Curr. Med. Imaging 20, e15734056305276 (2024); https://doi.org/10.2174/0115734056305276240730113140
/content/journals/cmir/10.2174/0115734056305276240730113140
/content/journals/cmir/10.2174/0115734056305276240730113140
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  • Article Type:     Research Article
Keyword(s): Congenital sensorineural hearing loss; Diffusion tensor imaging; Glymphatic system; Magnetic resonance imaging; Perivascular space; sex-matched healthy controls

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