Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Medical Imaging
  4. Fast Track Articles
  5. Fast Track Article
image of Imaging Characteristics of Primary Mucinous Cystadenocarcinoma of the Breast: A Case Report and Literature Review
file format pdf download PDF

Abstract

Introduction:

Mucinous Cystadenocarcinoma (MCA) of the breast remains a relatively rare condition, and to date, there is no systematic summary of its imaging manifestations. Therefore, this report presents a detailed account of the diagnosis and treatment of mucinous cystadenocarcinoma in a 40-year-old woman, with a particular focus on imaging findings. Additionally, we conducted a comprehensive literature review on this disease and summarized its key imaging features. This manuscript provides valuable insights and methodologies for the accurate diagnosis of mucinous cystadenocarcinoma.

Case Presentation:

We report a 40-year-old premenopausal woman who discovered multiple cysts in her left breast five years ago. Over the past two years, the size of these tumors has increased. Ultrasound examination indicated that the cysts had grown to 27 x 17mm. Following a puncture, the cysts were confirmed to be benign and were not monitored regularly. A year later, the patient's mass in the left breast increased, and an ultrasound exam indicated a suspicious mixed echo area in the upper outer quadrant, suggestive of a malignant lesion. Mammography showed amorphous suspicious calcifications in the lesion area, distributed in segments. Contrast-enhanced magnetic resonance imaging displayed non-mass-type enhancement of the lesion, with a dynamic enhanced imaging time-signal intensity curve (TIC) showing a rapidly rising plateau pattern. Postoperative pathology confirmed invasive carcinoma of the left breast along with mucinous cystadenocarcinoma. Four months after surgery, the patient developed multiple abnormal lymph nodes in the left axilla, which were confirmed to be metastasis upon pathology examination. Following radiotherapy, the patient's condition remained stable during the follow-up period.

Conclusion:

Most MCA lesions typically exhibit clear borders and irregular edges, with some displaying expansive growth and compression of surrounding tissues. Mammography can reveal calcified components in lesions. Ultrasound often reveals an isoechoic or hypoechoic mass with well-defined borders but irregular edges. Magnetic resonance imaging (MRI) can show clear boundaries and uneven enhancement of the lesions, and the time-intensity curve (TIC) of the mass area often shows an inflow enhancement pattern.

© 2024 The Author(s). Published by Bentham Science.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056345716241213075234
2025-01-02
2025-01-18

  • From This Site

    /content/journals/cmir/10.2174/0115734056345716241213075234
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/cmir/10.2174/0115734056345716241213075234/e15734056345716.html?itemId=/content/journals/cmir/10.2174/0115734056345716241213075234&mimeType=html&fmt=ahah

References

  1. Chen W.Y. Chen C.S. Chen H.C. Hung Y.J. Chu J.S. Mucinous cystadenocarcinoma of the breast coexisting with infiltrating ductal carcinoma. Pathol. Int. 2004 54 10 781 786 10.1111/j.1440‑1827.2004.01755.x 15482568
    [Google Scholar]
  2. Lee S.H. Chaung C.R. Mucinous metaplasia of breast carcinoma with macrocystic transformation resembling ovarian mucinous cystadenocarcinoma in a case of synchronous bilateral infiltrating ductal carcinoma. Pathol. Int. 2008 58 9 601 605 10.1111/j.1440‑1827.2008.02278.x 18801076
    [Google Scholar]
  3. Petersson F. Pang B. Thamboo T.P. Putti T.C. Mucinous cystadenocarcinoma of the breast with amplification of the HER2-gene confirmed by FISH: The first case reported. Hum. Pathol. 2010 41 6 910 913 10.1016/j.humpath.2009.10.020 20338619
    [Google Scholar]
  4. Sentani K. Tashiro T. Uraoka N. Aosaki Y. Yano S. Takaeko F. Yasui W. Primary mammary mucinous cystadenocarcinoma: Cytological and histological findings. Diagn. Cytopathol. 2012 40 7 624 628 10.1002/dc.21638 21472867
    [Google Scholar]
  5. Kim S.E. Park J.H. Hong S. Koo J.S. Jeong J. Jung W.H. Primary mucinous cystadenocarcinoma of the breast: Cytologic finding and expression of MUC5 are different from mucinous carcinoma. Korean J. Pathol. 2012 46 6 611 616 10.4132/KoreanJPathol.2012.46.6.611 23323116
    [Google Scholar]
  6. Deng Y. Xue D. Wang X. Xu S. Ao Q. Hu Z. Wang G. Mucinous cystadenocarcinoma of the breast with a basal‐like immunophenotype. Pathol. Int. 2012 62 6 429 432 10.1111/j.1440‑1827.2012.02810.x 22612513
    [Google Scholar]
  7. Nayak A. Bleiweiss I.J. Dumoff K. Bhuiya T.A. Mucinous cystadenocarcinoma of the breast: Report of 2 cases including one with long-term local recurrence. Int. J. Surg. Pathol. 2018 26 8 749 757 10.1177/1066896918775810 29745281
    [Google Scholar]
  8. Kamrani G. Nikbakhsh N. Hosseini A. Ghorbani H. Arefisigaroudi N. Davarian A. Mucinous cystadenocarcinoma of breast in a 69-year-old woman with positive hormone receptors, the first case reported. Caspian J. Intern. Med. 2021 12 S2 S444 S446 34760102
    [Google Scholar]
  9. Jain E. Kumar A. Jain R. Sharma S. Primary mucinous cystadenocarcinoma of the breast: A rare case report with review of literature. Int. J. Surg. Pathol. 2021 29 7 740 746 10.1177/1066896921991650 33635116
    [Google Scholar]
  10. Wang X. Li Y. Zhao P. Jia H. Dong X. Zhang L. Wang C. Primary mucinous cystadenocarcinoma of the breast: A clinicopathologic analysis of one case and review of the literature. Int. J. Clin. Exp. Pathol. 2020 13 10 2562 2568 33165376
    [Google Scholar]
  11. Zuo C. Xie J. Mixed primary mucinous cystadenocarcinoma and invasive ductal carcinoma of the breast: A case report and literature review. Transl. Cancer Res. 2022 11 12 4455 4464 10.21037/tcr‑22‑1596 36644191
    [Google Scholar]
  12. Moatasim A. Mamoon N. Primary breast mucinous cystadenocarcinoma and review of literature. Cureus J. Med. Sci. 2022 14 3 e23098 10.7759/cureus.23098
    [Google Scholar]
  13. Rosen P.P. Scott M. Cystic hypersecretory duct carcinoma of the breast. Am. J. Surg. Pathol. 1984 8 1 31 42 10.1097/00000478‑198401000‑00003 6320685
    [Google Scholar]
  14. Lin L.H. Hernandez O. Zhu K. Guth A. Cotzia P. Darvishian F. Genetic profile of primary mucinous cystadenocarcinoma of the breast—A case report. Breast J. 2021 27 9 731 734 10.1111/tbj.14265 34180564
    [Google Scholar]
  15. Seong M. Ko E.Y. Han B.K. Cho S.Y. Cho E.Y. Lee S.K. Lee J.E. Radiologic findings of primary mucinous cystadenocarcinoma of the breast: A report of two cases and a literature review. J. Breast Cancer 2016 19 3 330 333 10.4048/jbc.2016.19.3.330 27721884
    [Google Scholar]
  16. Domoto H. Terahata S. Yamazaki T. Sato K. Takeo H. Tamai S. Mucinous cystadenocarcinoma of the breast showing sulfomucin production. Histopathology 2000 36 6 567 569 10.1046/j.1365‑2559.2000.00918‑3.x 10849102
    [Google Scholar]
  17. Lin D.L. Hu J.L. Shao S.H. Sun D.M. Wang J.G. Primary mucinous cystadenocarcinoma of the breast with endocervical-like mucinous epithelium. Breast Care 2013 8 6 445 447 10.1159/000357657 24550753
    [Google Scholar]
  18. Sun M. Su S. Liu Q. Li Q. Wang K. Mammary synchronous mucinous cystadenocarcinoma and columnar cell mucinous carcinoma: A case report. Int. J. Clin. Exp. Pathol. 2020 13 9 2381 2386 33042347
    [Google Scholar]
  19. Rakıcı S. Gönüllü G. Gürsel Ş.B. Yıldız L. Bayrak İ.K. Yücel İ. Mucinous cystadenocarcinoma of the breast with estrogen receptor expression: A case report and review of the literature. Case Rep. Oncol. 2009 2 3 210 216 10.1159/000253866 20737039
    [Google Scholar]
  20. Li X. Peng J. Zhang Z. Zhang Y. Mammary mucinous cystadenocarcinoma. Breast J. 2012 18 3 282 283 10.1111/j.1524‑4741.2012.01238.x 22489551
    [Google Scholar]
  21. Hu Y. Tian C. Zhang X. Wei Q. Bian Y. 18F-FDG PET/CT findings in a patient with primary mucinous cystadenocarcinoma of the breast. Clin. Nucl. Med. 2020 45 2 159 160 10.1097/RLU.0000000000002902 31876834
    [Google Scholar]
  22. Kaur K. Shah A. Gandhi J. Trivedi P. Mucinous cystadenocarcinoma of the breast: A new entity with broad differentials—A case report. J. Egypt. Natl. Canc. Inst. 2022 34 1 9 10.1186/s43046‑022‑00112‑9 35224708
    [Google Scholar]
  23. Chen W.Y. Hu Y.H. Tsai Y.H. Hang J.F. Tan P.H. Chen C.J. Mucinous cystadenocarcinoma of the breast harbours TRPS1 expressions and PIK3CA alterations. Histopathology 2024 84 3 550 555 10.1111/his.15073 37983855
    [Google Scholar]
/content/journals/cmir/10.2174/0115734056345716241213075234
Loading
Imaging Characteristics of Primary Mucinous Cystadenocarcinoma of the Breast: A Case Report and Literature Review
Bentham Science Publishers , e15734056345716; https://doi.org/10.2174/0115734056345716241213075234
/content/journals/cmir/10.2174/0115734056345716241213075234
/content/journals/cmir/10.2174/0115734056345716241213075234
Loading

Data & Media loading...


  • Article Type:     Case Report
Keywords: Primary mucinous cystadenocarcinoma of the breast ; Imaging diagnosis ; Case report

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test