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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background:

MRI of patients with locally advanced rectal cancer (LARC) can predict the pathological complete response (pCR) to preoperative chemoradiation therapy (CRT). Our purpose was to use MRI results to evaluate the diagnostic value of combined changes in signal intensity (SI) and volume (V) of patients with LARC for predicting pCR to CRT.

Methods:

This retrospective study on 100 patients with LARC analyzed clinical and imaging data that were collected from March, 2018, to March, 2020. Before and after CRT, T2-weighted (T2W), apparent diffusion coefficient (ADC), and contrast-enhanced T1-weighted (ceT1W) data were analyzed. Percent changes of V (%∆V) and relative SI ratio (%∆SIR) on different sequences were calculated. After CRT, patients had pathological confirmation as pCR or non-pCR. Data were analyzed using nonparametric tests and receiver operating characteristic (ROC) analysis.

Results:

There were 34 pCR and 66 non-pCR patients. Except for ADC-%∆SIR, the combined parameters and single parameters had a greater decrease in the pCR group. The combination of ADC-%∆V and T2W-%∆SIR had the greatest diagnostic value (AUC=0.85,cutoff=0.23%) and the combination of ADC-%∆V% and ∆SIR had the best accuracy (89%, cutoff=44.11%). Except for T2W-%∆V and T2W-%∆SIR, the different sequences had moderate differences in diagnostic performance. The diagnostic performance of combined parameters or single parameters on ADC and T2W was significantly better than those on ceT1W (p<0.01).

Conclusion:

All sequences except ADC-%∆SIR provided reliable predictions of pCR, although ceT1W data had limited usefulness.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2023-11-28
2025-06-26

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/content/journals/cmir/10.2174/0115734056258900231025043146
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Combination of Multiple MRI Parameters Related to Signal Intensity and Volume for Predicting Response to Neoadjuvant Chemoradiotherapy by Patients with Locally Advanced Rectal Cancer
Curr. Med. Imaging 20, e15734056258900 (2024); https://doi.org/10.2174/0115734056258900231025043146
/content/journals/cmir/10.2174/0115734056258900231025043146
/content/journals/cmir/10.2174/0115734056258900231025043146
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  • Article Type:     Research Article
Keyword(s): Chemoradiotherapy; Complete response; LARC; MRI; Rectal cancer; Tumor volumetry

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