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2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

In the last few years, coronavirus disease 2019 (COVID-19) has changed human lifestyle, behavior, and perception of life. This disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). In the literature, there are limited studies about the late renal effects of COVID-19 that reflect the systemic involvement of this disease.

Aim

In the present study, we aimed to compare sonoelastographic changes in both kidneys between patients who had totally recovered from COVID-19 and healthy individuals using strain wave elastography (SWE).

Methods

This study was conducted between June 2021 and May 2022 in Kahramanmaraş City Hospital Department of Radiology. File and archive records were retrospectively evaluated. Basic demographic, laboratory, and renal ultrasonography (USG) and sonoelastographic findings were screened and noted. Two groups were defined to compare sonoelastographic findings. Post-/long-COVID-19 group had 92 post-long COVID-19 patients, and the comparator group comprised healthy individuals”. Both groups’ demographic, laboratory, and ultrasound-elastographic findings were assessed.

Results

The post-long COVID-19 group had a higher renal elastographic value than the comparator group (1.52 [0.77–2.3] . 0.96 [0.54–1.54], p<0.001). There were no statistically significant differences between the two groups in terms of age (p=0.063), gender (p=0.654), or body mass index (BMI) (p=0.725), however, there was a significant difference observed between the two groups in the renal strain ratio (RSR). According to an receiver operating characteristic curve (ROC) analysis, an RSR cutoff of >1.66 predicted post-long COVID-19 with 44.9% sensitivity and 81.9% specificity. (AUC=0.655, p<0.001). A separate ROC analysis was performed to predict post-long COVID-19 with a BMI cutoff of <33.52, kg/m2 sensitivity of 92.4% and specificity of 17% (AUC=0.655, p<0.001).

Conclusion

We demonstrated that renal parenchymal stiffness increases with SWE in post-long COVID-19 patients.

© 2024 Çitil and Aksu
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-07-25

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References

  1. van der HoekL. PyrcK. JebbinkM.F. Vermeulen-OostW. BerkhoutR.J.M. WolthersK.C. Wertheim-van DillenP.M.E. KaandorpJ. SpaargarenJ. BerkhoutB. Identification of a new human coronavirus.Nat. Med.200410436837310.1038/nm102415034574
     [Google Scholar]
  2. BulutC. KatoY. Epidemiology of COVID-19.Turk. J. Med. Sci.202050SI-156357010.3906/sag‑2004‑17232299206
     [Google Scholar]
  3. PetersenE. Gökengi̇nD. SARS-CoV-2 epidemiology and control, different scenarios for Turkey.Turk. J. Med. Sci.202050SI-150951410.3906/sag‑2003‑26032283894
     [Google Scholar]
  4. SalianV.S. WrightJ.A. VedellP.T. NairS. LiC. KandimallaM. TangX. Carmona PorqueraE.M. KalariK.R. KandimallaK.K. COVID-19 transmission, current treatment, and future therapeutic strategies.Mol. Pharm.202118375477110.1021/acs.molpharmaceut.0c0060833464914
     [Google Scholar]
  5. LiY. JiD. CaiW. HuY. BaiY. WuJ. XuJ. Clinical characteristics, cause analysis and infectivity of COVID-19 nucleic acid repositive patients: A literature review.J. Med. Virol.20219331288129510.1002/jmv.2649132890414
     [Google Scholar]
  6. HuB. GuoH. ZhouP. ShiZ.L. Characteristics of SARS-CoV-2 and COVID-19.Nat. Rev. Microbiol.202119314115410.1038/s41579‑020‑00459‑733024307
     [Google Scholar]
  7. PiazzaG. CampiaU. HurwitzS. SnyderJ.E. RizzoS.M. PfefermanM.B. MorrisonR.B. LeivaO. FanikosJ. NauffalV. AlmarzooqZ. GoldhaberS.Z. Registry of arterial and venous thromboembolic complications in patients With COVID-19.J. Am. Coll. Cardiol.202076182060207210.1016/j.jacc.2020.08.07033121712
     [Google Scholar]
  8. AliM.A.M. SpinlerS.A. COVID-19 and thrombosis: From bench to bedside.Trends Cardiovasc. Med.202131314316010.1016/j.tcm.2020.12.00433338635
     [Google Scholar]
  9. LuY. PanL. ZhangW.W. ChengF. HuS.S. ZhangX. JiangH. A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19.Int. J. Infect. Dis.2020100344110.1016/j.ijid.2020.08.02332798659
     [Google Scholar]
  10. WichmannD. SperhakeJ.P. LütgehetmannM. SteurerS. EdlerC. HeinemannA. HeinrichF. MushumbaH. KniepI. SchröderA.S. BurdelskiC. de HeerG. NierhausA. FringsD. PfefferleS. BeckerH. Bredereke-WiedlingH. de WeerthA. PaschenH.R. Sheikhzadeh-EggersS. StangA. SchmiedelS. BokemeyerC. AddoM.M. AepfelbacherM. PüschelK. KlugeS. Autopsy findings and venous thromboembolism in patients with COVID-19.Ann. Intern. Med.2020173426827710.7326/M20‑200332374815
     [Google Scholar]
  11. KayeA.D. OkeaguC.N. TortorichG. PhamA.D. LyE.I. BrondeelK.C. EngM.R. LuediM.M. UrmanR.D. CornettE.M. COVID-19 impact on the renal system: Pathophysiology and clinical outcomes.Baillieres. Best Pract. Res. Clin. Anaesthesiol.202135344945910.1016/j.bpa.2021.02.00434511232
     [Google Scholar]
  12. BenedettiC. WaldmanM. ZazaG. RiellaL.V. CravediP. COVID-19 and the kidneys: An update.Front. Med.2020742310.3389/fmed.2020.0042332793615
     [Google Scholar]
  13. PrasadN. AgrawalS. NephrologyO. COVID 19 and acute kidney injury.Indian J. Nephrol.202030316116510.4103/ijn.IJN_120_2033013062
     [Google Scholar]
  14. LiZ. WuM. YaoJ. Caution on kidney dysfunctions of COVID-19 patients.Rochester, NYSocial Science Research Network202010.2139/ssrn.3559601
     [Google Scholar]
  15. AksuY. KahveciS. TiryakiŞ. ŞahinM. MutluF. Assessment of cerebral arterial flow volume changes with carotid vertebral artery duplex doppler ultrasound in young-middle-aged subclinical hashimoto thyroiditis patients.Curr. Med. Imaging Rev.2023197e22122221210710.2174/157340561966622122210580136567281
     [Google Scholar]
  16. MakitaA. NagaoT. MiyoshiK. KoizumiY. KurataM. KondoF. ShichijoS. HirookaM. YamaguchiO. The association between renal elasticity evaluated by Real-time tissue elastography and renal fibrosis.Clin. Exp. Nephrol.202125998198710.1007/s10157‑021‑02063‑233963937
     [Google Scholar]
  17. PerideI. RădulescuD. NiculaeA. EneV. BratuO.G. ChecherițăI.A. Value of ultrasound elastography in the diagnosis of native kidney fibrosis.Med. Ultrason.201618336236910.11152/mu.2013.2066.183.per27622414
     [Google Scholar]
  18. DeWallR.J. Ultrasound elastography: Principles, techniques, and clinical applications.Crit. Rev. Biomed. Eng.201341111910.1615/CritRevBiomedEng.201300699123510006
     [Google Scholar]
  19. JiaW. LuoT. DongY. ZhangX. ZhanW. ZhouJ. Breast elasticity imaging techniques: Comparison of strain elastography and shear-wave elastography in the same population.Ultrasound Med. Biol.202147110411310.1016/j.ultrasmedbio.2020.09.02233109379
     [Google Scholar]
  20. InciM.F. KalayciT.O. TanS. KarasuS. AlbayrakE. CakirV. OcalI. OzkanF. Diagnostic value of strain elastography for differentiation between renal cell carcinoma and transitional cell carcinoma of kidney.Abdom. Radiol.20164161152115910.1007/s00261‑016‑0658‑226880174
     [Google Scholar]
  21. KolesovaO. VanagaI. LaivacumaS. DerovsA. KolesovsA. RadzinaM. PlatkajisA. EgliteJ. HaginaE. ArutjunanaS. PutrinsD.S. StorozenkoJ. RozentaleB. ViksnaL. Intriguing findings of liver fibrosis following COVID-19.BMC Gastroenterol.202121137010.1186/s12876‑021‑01939‑734635073
     [Google Scholar]
  22. SigristR.M.S. LiauJ. KaffasA.E. ChammasM.C. WillmannJ.K. Ultrasound elastography: Review of techniques and clinical applications.Theranostics2017751303132910.7150/thno.1865028435467
     [Google Scholar]
  23. OzturkA. GrajoJ.R. DhyaniM. AnthonyB.W. SamirA.E. Principles of ultrasound elastography.Abdom. Radiol.201843477378510.1007/s00261‑018‑1475‑629487968
     [Google Scholar]
  24. BarrR.G. Shear wave liver elastography.Abdom. Radiol.201843480080710.1007/s00261‑017‑1375‑129116341
     [Google Scholar]
  25. KocA. SumbulH. GülümsekE. Increased renal cortical stiffness in patients with advanced diabetic kidney disease.Saudi J. Kidney Dis. Transpl.201930113815010.4103/1319‑2442.25290330804275
     [Google Scholar]
  26. DemirtasC.O. KeklikkiranC. ErgencI. Erturk SengelB. EskidemirG. CinelI. OdabasiZ. KortenV. YilmazY. Liver stiffness is associated with disease severity and worse clinical scenarios in coronavirus disease 2019: A prospective transient elastography study.Int. J. Clin. Pract.2021759e1436310.1111/ijcp.1436333993597
     [Google Scholar]
  27. EffenbergerM. GranderC. FritscheG. Bellmann-WeilerR. HartigF. WildnerS. SeiwaldS. AdolphT.E. ZollerH. WeissG. TilgH. Liver stiffness by transient elastography accompanies illness severity in COVID-19.BMJ Open Gastroenterol.202071e00044510.1136/bmjgast‑2020‑00044532665398
     [Google Scholar]
  28. KeskinS. GüvenS. KeskinZ. ÖzbinerH. KerimoğluÜ. YeşildağA. Strain elastography in the characterization of renal cell carcinoma and angiomyolipoma.Can. Urol. Assoc. J.201591-26710.5489/cuaj.234925737764
     [Google Scholar]
  29. LeongS.S. WongJ.H.D. Md ShahM.N. VijayananthanA. JalalonmuhaliM. NgK.H. Shear wave elastography in the evaluation of renal parenchymal stiffness in patients with chronic kidney disease.Br. J. Radiol.20189110892018023510.1259/bjr.2018023529869920
     [Google Scholar]
  30. YildirimU.M. Şahi̇nE. SolakA. ÖrsB. SerterS. Diagnostic accuracy of kidney shear wave elastography at the diagnosis of ureteral stones.Acta Medica Alanya2022613810.30565/medalanya.876543
     [Google Scholar]
  31. BobF. GrosuI. SporeaI. BotaS. PopescuA. SimaA. ŞirliR. PetricaL. TimarR. SchillerA. Ultrasound-based shear wave elastography in the assessment of patients with diabetic kidney disease.Ultrasound Med. Biol.201743102159216610.1016/j.ultrasmedbio.2017.04.01928720285
     [Google Scholar]
  32. MahalingasivamV. SuG. IwagamiM. DavidsM.R. WetmoreJ.B. NitschD. COVID-19 and kidney disease: Insights from epidemiology to inform clinical practice.Nat. Rev. Nephrol.202218848549810.1038/s41581‑022‑00570‑335418695
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056258544231115103528
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Does Post-/Long-COVID-19 Affect Renal Stiffness without Causing any Chronic Systemic Disorders?
Curr. Med. Imaging 20, e15734056258544 (2024); https://doi.org/10.2174/0115734056258544231115103528
/content/journals/cmir/10.2174/0115734056258544231115103528
/content/journals/cmir/10.2174/0115734056258544231115103528
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  • Article Type:     Research Article
Keyword(s): Elastography; Kidneys; Post-long COVID-19; SARS-COV-2 diseases; Ultrasound

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