Skip to content
2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
side by side viewer icon HTML

Abstract

Background

The definition of oligometastasis is still controversial. Cytoreductive nephrectomy and metastasectomy are important approaches in selected patients with oligometastasis for improving survival. We aimed to present our laparoscopic metastasectomy experience in a rare case of contralateral adrenal metastasis in an oligometastatic kidney tumor.

Case Report

A 52-year-old male patient was admitted to our clinic with the diagnosis of an incidental right renal mass. On contrast-enhanced abdominal CT revealed a mass reaching approximately 8 cm in diameter in the right kidney located in the middle pole. On contrast-enhanced thorax, CT showed a metastatic lesion in the left main bronchus bifurcation. The patient underwent an open radical nephrectomy with the diagnosis of an oligometastatic right renal mass. His pathology was reported as clear cell renal cell carcinoma (ccRCC). The patient was referred to the medical oncology clinic for immunotherapy. The metastatic lesion in the lung completely regressed in the follow-up of the patient who was started on Chek point inhibitors. However, he was referred to our clinic after an incidental metachronous mass was detected in the contralateral left adrenal in FDG PET/CT (SUVmax: 6.7) in 1st year. Dynamic contrast-enhanced MRI was performed to reevaluate and for mass characterization, and a 4 cm mass was observed in the left contralateral adrenal. Laparoscopic metastasectomy was performed for the left adrenal mass. No recurrence or adrenal insufficiency developed in the 6-month follow-up after discharge.

Conclusion

Transperitoneal adrenalectomy is a minimally invasive method that can be safely performed in metastatic adrenal masses. Although contralateral adrenal metastasis is rare in ccRCC, it should be kept in mind that adrenal metastasis may develop in the late period in patients with a history of renal cancer.

© 2024 The Author(s). Published by Bentham Open. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056244676231016094516
2024-01-01
2024-11-22
Loading full text...

Full text loading...

/deliver/fulltext/cmir/20/1/CMIM-20-e15734056244676.html?itemId=/content/journals/cmir/10.2174/0115734056244676231016094516&mimeType=html&fmt=ahah

References

  1. CapitanioU. BensalahK. BexA. BoorjianS.A. BrayF. ColemanJ. GoreJ.L. SunM. WoodC. RussoP. Epidemiology of renal cell carcinoma.Eur. Urol.2019751748410.1016/j.eururo.2018.08.03630243799
    [Google Scholar]
  2. VasudevN.S. WilsonM. StewartG.D. AdeyojuA. CartledgeJ. KimuliM. DattaS. HanburyD. HroudaD. OadesG. PatelP. SoomroN. SullivanM. WebsterJ. SelbyP.J. BanksR.E. Challenges of early renal cancer detection: symptom patterns and incidental diagnosis rate in a multicentre prospective UK cohort of patients presenting with suspected renal cancer.BMJ Open2020105e03593810.1136/bmjopen‑2019‑03593832398335
    [Google Scholar]
  3. MotzerR.J. BanderN.H. NanusD.M. Renal-cell carcinoma.N. Engl. J. Med.19963351286587510.1056/NEJM1996091933512078778606
    [Google Scholar]
  4. WangK. WangJ. SunJ. ZhongD. TaiS. XuD. FanY. Renal cell carcinoma with metachronous metastasis to the contralateral adrenal gland and urinary bladder: A case report.Oncol. Lett.20151052749275210.3892/ol.2015.372226722236
    [Google Scholar]
  5. MikhailM. ChuaK.J. KhizirL. TabakinA. SingerE.A. Role of metastasectomy in the management of renal cell carcinoma.Front. Surg.2022994360410.3389/fsurg.2022.94360435965871
    [Google Scholar]
  6. WeichselbaumR.R. HellmanS. Oligometastases revisited.Nat. Rev. Clin. Oncol.20118637838210.1038/nrclinonc.2011.4421423255
    [Google Scholar]
  7. CulpS.H. TannirN.M. AbelE.J. MargulisV. TamboliP. MatinS.F. WoodC.G. Can we better select patients with metastatic renal cell carcinoma for cytoreductive nephrectomy?Cancer2010116143378338810.1002/cncr.2504620564061
    [Google Scholar]
  8. CozzoliA. MilanoS. CancariniG. ZanotelliT. CunicoS.C. Surgery of lung metastases in renal cell carcinoma.Br. J. Urol.199575444544710.1111/j.1464‑410X.1995.tb07262.x7788253
    [Google Scholar]
  9. KollenderY. BickelsJ. PriceW.M. KellarK.L. ChenJ. MerimskyO. MellerI. MalawerM.M. Metastatic renal cell carcinoma of bone: Indications and technique of surgical intervention.J. Urol.200016451505150810.1016/S0022‑5347(05)67016‑411025692
    [Google Scholar]
  10. AndohH. KurokawaT. YasuiO. ShibataS. SatoT. Resection of a solitary pancreatic metastasis from renal cell carcinoma with a gallbladder carcinoma: Report of a case.Surg. Today200434327227510.1007/s00595‑003‑2680‑614999544
    [Google Scholar]
  11. BalabanD.V. ComanL. MarinF.S. BalabanM. TabaceliaD. VasilescuF. CostacheR.S. JingaM. Metastatic renal cell carcinoma to pancreas: Case series and review of the literature.Diagnostics2023138136810.3390/diagnostics1308136837189469
    [Google Scholar]
  12. WangW. LiH. LiY. GaoZ. FengF. LinC. Metachronous metastasis to contralateral retroperitoneal adipose tissue after radical nephrectomy: A case report and review of the literature.J. Int. Med. Res.20194721035104210.1177/030006051881617430556455
    [Google Scholar]
  13. KesslerO.J. MukamelE. WeinsteinR. GayerE. KonichezkyM. ServadioC. Metachronous renal cell carcinoma metastasis to the contralateral adrenal gland.Urology199851453954310.1016/S0090‑4295(97)00698‑59586603
    [Google Scholar]
  14. AntonelliA. CozzoliA. SimeoneC. ZaniD. ZanotelliT. PortesiE. Cosciani CunicoS. Surgical treatment of adrenal metastasis from renal cell carcinoma: A single-centre experience of 45 patients.BJU Int.200697350550810.1111/j.1464‑410X.2006.05934.x16469016
    [Google Scholar]
  15. RitchieA.W. deKernionJ.B. The natural history and clinical features of renal carcinoma.Semin. Nephrol.1987721311393306862
    [Google Scholar]
  16. KumarR. ShamimS.A. ShandalV. SharmaP. GadodiaA. MalhotraA. FDG PET/CT in detection of adrenal metastasis in patients with renal cell carcinoma.Clin. Nucl. Med.201136751351710.1097/RLU.0b013e318217543521637050
    [Google Scholar]
  17. CheeC. RavinthiranT. ChengC. Laparoscopic adrenalectomy: experience with transabdominal and retroperitoneal approaches.Urology1998511293210.1016/S0090‑4295(97)00468‑89457284
    [Google Scholar]
  18. MéjeanA. RavaudA. ThezenasS. ColasS. BeauvalJ.B. BensalahK. GeoffroisL. Thiery-VuilleminA. CormierL. LangH. GuyL. GravisG. RollandF. LinassierC. LechevallierE. BeislandC. AitchisonM. OudardS. PatardJ.J. TheodoreC. ChevreauC. LaguerreB. HubertJ. Gross-GoupilM. BernhardJ.C. AlbigesL. TimsitM.O. LebretT. EscudierB. Sunitinib alone or after nephrectomy in metastatic renal-cell carcinoma.N. Engl. J. Med.2018379541742710.1056/NEJMoa180367529860937
    [Google Scholar]
  19. AltA.L. BoorjianS.A. LohseC.M. CostelloB.A. LeibovichB.C. BluteM.L. Survival after complete surgical resection of multiple metastases from renal cell carcinoma.Cancer2011117132873288210.1002/cncr.2583621692048
    [Google Scholar]
  20. PetraliaG. RoscignoM. ZigeunerR. StradaE. SozziF. Da PozzoL. GuazzoniG. CestariA. SaloniaA. ScattoniV. MontorsiF. RigattiP. BertiniR. 450 Complete metastasectomy is an independent predictor of cancer-specific survival in patients with clinically metastatic renal cell carcinoma.Eur. Urol. Suppl.20109216210.1016/S1569‑9056(10)60446‑0
    [Google Scholar]
  21. PowlesT. TomczakP. ParkS.H. VenugopalB. FergusonT. SymeonidesS.N. HajekJ. GurneyH. ChangY.H. LeeJ.L. SarwarN. Thiery-VuilleminA. Gross-GoupilM. MahaveM. HaasN.B. SawryckiP. BurgentsJ.E. XuL. ImaiK. QuinnD.I. ChoueiriT.K. TomczakP. ChoueiriT. ParkS.H. VenugopalB. FergusonT.R. HajekJ. LinT-P. SymeonidesS.N. LeeJ.L. SawryckiP. HaasN.B. GurneyH.P. MahaveM. SarwarN. Thiery-VuilleminA. Gross-GoupilM. ChevreauC. BurkeJ.M. DoshiG. MelicharB. TopartD. OudardS. KopyltsovE. HammersH-J. QuinnD.I. AlvaA. MenezesJ.J. SilvaA.G. WinquistE.W. HamzajA. ProcopioG. KaraszewskaB. Nowakowska-ZajdelE.M. AlekseevB.Y. GafanovR.A. IzmailovA. SemenovA. AfanasyevS.G. LipatovO.N. PowlesT.B. SrinivasS. McDermottD. KochuparambilS.T. DavisI.D. PeltolaK. SabbatiniR. ChungJ. ShkolnikM.I. MatveevV.B. Gajate BorauP. McCuneS. HutsonT.E. DriA. SalesS.C. YeungC. Alcala CastroC.M. BostromP. LaguerreB. ButtiglieroC. de GiorgiU. FominE.A. ZakhariaY. HwangC. SingerE.A. YorioJ.T. WaterhouseD. KowalyszynR.D. AlfieM.S. Yanez RuizE. BuchlerT. KankaanrantaK. FerrettiG. KimuraG. NishimuraK. MasumoriN. TamadaS. KatoH. KitamuraH. DanielewiczI. Wojcik-TomaszewskaJ. Sala GonzalezN. ChiuK-Y. AtkinsM.B. HeathE. Rojas-UribeG.A. Gonzalez FernandezM.E. FeyerabendS. PignataS. NumakuraK. Cybulska StopaB. ZukovR. Climent DuranM.A. Maroto ReyP.J. Montesa PinoA. ChangC-H. VengalilS. WaddellT.S. CobbP.W. HaukeR. AndersonD.M. SarantopoulosJ. GourdinT. ZhangT. JayramG. FeinL.E. HarrisC. BeatoP.M.M. FloresF. EstayA. RubianoJ.A. BedkeJ. HauserS. NeisiusA. BuschJ. AnaiS. TsunemoriH. SawkaD. Sikora-KupisB. ArranzJ.A. DelgadoI. ChenC-H. GundersonE. TykodiS. KoletskyA. ChenK. AgrawalM. KaenD.L. SadeJ.P. TatangeloM.D. ParnisF. BarbosaF.M. FaucherG. IqbalN. MarceauD. ParadisJ-B. HannaN. AcevedoA. IbanezC. VillanuevaL. GalazP.P. DurangoI.C. MannehR. KralZ. HoleckovaP. HakkarainenH. RonkainenH. Abadie-LacourtoisieS. TartasS. GoebellP.J. GrimmM-O. HoefnerT. WirthM. PanicA. Schultze-SeemannW. YokomizoA. MizunoR. UemuraH. EtoM. TsujihataM. MatsukawaY. MurakamiY. KimM. HambergP. Marczewska-SkrodzkaM. SzczylikC. HumphreysA.C. JiangP. KumarB. LuG. DesaiA. KaramJ.A. KeoghG. FlemingM. ZarbaJ.J. LeivaV.E. MendezG.A. HarrisS.J. BrownS.J. Antonio JuniorJ.N. CostamilanR.C. RochaR.O. MunizD. BrustL. LalaniA-K. GrahamJ. LevesqueM. OrlandiF. KotasekR. DevilleJ.L. BorchielliniD. MerseburgerA. RinkM. RoosF. McDermottR. OyamaM. YamamotoY. TomitaY. MiuraY. IoritaniN. WestgeestH. KubiatowskiT. BalW. Girones SarrioR. RoweJ. ProwD.M. SenecalF. Hashemi-SadraeiN. ColeS.W. KendallS.D. RichardsD.A. SchnadigI.D. GuptaM. Pembrolizumab versus placebo as post-nephrectomy adjuvant therapy for clear cell renal cell carcinoma (KEYNOTE-564): 30-month follow-up analysis of a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.Lancet Oncol.20222391133114410.1016/S1470‑2045(22)00487‑936055304
    [Google Scholar]
  22. ImaiT. KikumoriT. OhiwaM. MaseT. FunahashiH. A case-controlled study of laparoscopic compared with open lateral adrenalectomy.Am. J. Surg.19991781505310.1016/S0002‑9610(99)00126‑910456703
    [Google Scholar]
  23. ObaT. SatoN. TamuraT. FujimotoK. MatsuyamaA. HirataK. Gallbladder metastasis of renal cell carcinoma presenting as a hypervascular polypoid lesion: Case report of two cases with immunohistochemical analysis.Surg. Case Rep.2020618610.1186/s40792‑020‑00814‑z32347406
    [Google Scholar]
/content/journals/cmir/10.2174/0115734056244676231016094516
Loading
/content/journals/cmir/10.2174/0115734056244676231016094516
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test