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Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Aim:

This study aims to assess the accuracy of computed tomography (CT) in detecting recurrent laryngeal tumors after failed chemoradiation therapy (CRT).

Background:

Local recurrence of laryngeal tumors following CRT has been reported in approximately 25%, yet it is often difficult to detect.

Methods:

Ten patients with laryngeal cancer who failed CRT and subsequently underwent salvage total laryngectomy were included. The laryngeal subsites involved in the tumor were identified based on postoperative pathology. The corresponding preoperative CT scans were selected for review by seven experts (head-and-neck surgeons or radiologists) who scored the extent of tumor spread on each scan on a 5-point scale, from no tumor detected to clearly visible tumor.

Results:

The rates of high tumor detectability (scores 4-5) varied according to laryngeal subsite, from 75% in the glottic region, to 45% in the subglottic region, and to 19% in the supraglottic region (=0.01). The detectability rates were higher on scans performed 2 years or more after CRT.

Conclusion:

The CT evaluation of laryngeal cancer after CRT has limited value, particularly in the epiglottis and subglottis.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2023-10-19
2025-04-22

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References

  1. JemalA. SiegelR. WardE. MurrayT. XuJ. ThunM.J. Cancer statisticsCA Cancer J. Clin.2007571436610.3322/canjclin.57.1.4317237035
     [Google Scholar]
  2. JemalA. MurrayT. WardE. SamuelsA. TiwariR.C. GhafoorA. FeuerE.J. ThunM.J. Cancer Statistics,CA Cancer J. Clin.2005551103010.3322/canjclin.55.1.1015661684
     [Google Scholar]
  3. MorganR.J. AlvarezR.D. ArmstrongD.K. Ovarian cancer, version 2.2013.J Natl Compr Canc Netw.201311101199120910.6004/jnccn.2013.014224142821
     [Google Scholar]
  4. MukherjiS.K. WeadockW.J. Imaging of the post-treatment larynx.Eur. J. Radiol.200244210811910.1016/S0720‑048X(02)00068‑212413679
     [Google Scholar]
  5. AllenC.T. LeeC.J. MeratiA.L. Clinical assessment and treatment of the dysfunctional larynx after radiation.Otolaryngol Head Neck Surg201314968309
     [Google Scholar]
  6. STEPHENB.E> DAVIDR.B. AJCC Cancer Staging Handbook.7th ed.Springer2010
     [Google Scholar]
  7. MukherjiS.K. MancusoA.A. KotzurI.M. MendenhallW.M. KubilisP.S. TartR.P. LeeW.R. FreemanD. Radiologic appearance of the irradiated larynx. Part I. Expected changes.Radiology1994193114114810.1148/radiology.193.1.80908828090882
     [Google Scholar]
  8. ChampsaurP. Parlier-CuauC. BrunetC. MoulinG. ChagnaudC. LassauJ.P. KasbarianM. Serial anatomy of the larynx in MRI: MRI-histologic correlations.Surg. Radiol. Anat.200022151110.1007/s00276‑000‑0005‑710863740
     [Google Scholar]
  9. ChuM.M.A.Y. KositwattanarerkA. LeeD.J. MakkarJ.S. GendenE.M. KaoJ. PackerS.H. SomP.M. KostakogluL. FDG PET with contrast-enhanced CT: A critical imaging tool for laryngeal carcinoma.Radiographics20103051353137210.1148/rg.30509576420833855
     [Google Scholar]
  10. MukherjiS.K. MancusoA.A. KotzurI.M. MendenhallW.M. KubilisP.S. TartR.P. FreemanD. LeeW.R. Radiologic appearance of the irradiated larynx. Part II. Primary site response.Radiology1994193114915410.1148/radiology.193.1.80908838090883
     [Google Scholar]
  11. BeckerM. BurkhardtK. DulguerovP. AllalA. Imaging of the larynx and hypopharynx.Eur. J. Radiol.200866346047910.1016/j.ejrad.2008.03.02718495402
     [Google Scholar]
  12. ShahJ.P. LoreeT.R. KowalskiL. Conservation surgery for radiation-failure carcinoma of the glottic larynx.Head Neck199012432633110.1002/hed.28801204092361863
     [Google Scholar]
  13. Rodríguez-CuevasS. LabastidaS. GonzalezD. BriseñoN. CortesH. Partial laryngectomy as salvage surgery for radiation failures in T1–T2 laryngeal cancer.Head Neck199820763063310.1002/(SICI)1097‑0347(199810)20:7<630::AID‑HED9>3.0.CO;2‑K9744464
     [Google Scholar]
  14. ClarkJ. MorganG. VenessM. DaltonC. KalninsI. Salvage with supracricoid partial laryngectomy after radiation failure.ANZ J. Surg.2005751195896210.1111/j.1445‑2197.2005.03587.x16336387
     [Google Scholar]
  15. GussackGS HudginsPA Imaging modalities in recurrent head and neck tumors.Laryngoscope.1991101211912410.1288/00005537‑199102000‑00003
     [Google Scholar]
  16. O’BrienP.C. Tumour recurrence or treatment sequelae following radiotherapy for larynx cancer.J. Surg. Oncol.199663213013510.1002/(SICI)1096‑9098(199610)63:2<130::AID‑JSO11>3.0.CO;2‑A8888807
     [Google Scholar]
  17. ZbärenP. ChristeA. CaversaccioM.D. StaufferE. ThoenyH.C. Pretherapeutic staging of recurrent laryngeal carcinoma: Clinical findings and imaging studies compared with histopathology.Otolaryngol. Head Neck Surg.2007137348749110.1016/j.otohns.2007.03.02217765781
     [Google Scholar]
  18. HanM.W. KimS.A. ChoK.J. LeeJ.H. LimH.K. RohJ.L. ChoiS.H. KimS.Y. NamS.Y. Diagnostic accuracy of computed tomography findings for patients undergoing salvage total laryngectomy.Acta Otolaryngol.2013133662062510.3109/00016489.2012.76135223448356
     [Google Scholar]
  19. Shoffel-HavakukH. LahavY. MeidanB. HaimovichY. WarmanM. HainM. HamzanyY. BrodskyA. Landau-ZemerT. HalperinD. Does narrow band imaging improve preoperative detection of glottic malignancy? A matched comparison study.Laryngoscope2017127489489910.1002/lary.2626327753087
     [Google Scholar]
  20. PurohitB.S. AilianouA. DulguerovN. BeckerC.D. RatibO. BeckerM. FDG-PET/CT pitfalls in oncological head and neck imaging.Insights Imaging20145558560210.1007/s13244‑014‑0349‑x25154759
     [Google Scholar]
  21. ErdiY.E. Limits of tumor detectability in nuclear medicine and PET.Mol. Imaging Radionucl. Ther.2012211232823486256
     [Google Scholar]
  22. ZhangM. ZhaoX. LiW. ZhangY. TaoR. DuQ. Cross-scene joint classification of multisource data with multilevel domain adaption network.IEEE Trans. Neural Netw. Learn. Syst.2023PP111310.1109/TNNLS.2023.326259937023167
     [Google Scholar]
  23. ZhangY. LiW. SunW. TaoR. DuQ. Single-source domain expansion network for cross-scene hyperspectral image classification.IEEE Trans. Image Process.20233211498151210.1109/TIP.2023.324385337027628
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056240028231016074150
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The Value of Computed Tomography in Recurrent Laryngeal Cancer Following Organ Preservation Therapy
Curr. Med. Imaging 20, e15734056240028 (2024); https://doi.org/10.2174/0115734056240028231016074150
/content/journals/cmir/10.2174/0115734056240028231016074150
/content/journals/cmir/10.2174/0115734056240028231016074150
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  • Article Type:     Research Article
Keyword(s): Chemoradiotherapy; Computed tomography; Laryngeal cancer; Organ preservation therapy; Recurrence; Salvage laryngectomy

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