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Volume 31, Issue 40
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

Tuberculosis (TB) is a serious disease that still affects humanity, despite being old, caused by the bacterium (). The emergence of drug-resistant strains has alarmed governments and international organizations, such as the World Health Organization (WHO). The need for research on new drugs that are effective in a shorter treatment time and active against resistant strains still persists.

Objective

The objective of this study is to synthesize and evaluate forty-four substituted 2-trifluoromethyl-4-quinolinylhydrazone analogs, as probable inhibitors of growth.

Methods

The anti-mycobacterial activities of all tested compounds against strains, as well as the cytotoxicity test, were evaluated using the microplate procedure with broth microdilution assay.

Results

Thirteen compounds exhibited some activity against sensitive strain ATCC 27294, six of which were the most active: , , , , , and ; with MIC around 7 - 8 μM, close to that presented by ethambutol (15.9 μM), a drug used in the treatment of tuberculosis. These same compounds also were active against a resistant strain of (T113), with MIC around 7 – 8 μM. Three of these compounds , , and were not cytotoxic against Vero cells at concentrations near the MIC.

Conclusion

This study indicates the importance of the hydrazone function to obtain promising anti-TB compounds and open new perspectives for drug development.

© 2024 Bentham Science Publishers
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2023-10-15
2025-06-22

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/content/journals/cmc/10.2174/0109298673267136231003113803
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Synthesis and Anti-bacterial Activity of New Substituted 2-trifluoromethyl-4-quinolinylhydrazone Analogs against Mycobacterium tuberculosis Strains
Curr. Med. Chem. 31, 6713 (2024); https://doi.org/10.2174/0109298673267136231003113803
/content/journals/cmc/10.2174/0109298673267136231003113803
/content/journals/cmc/10.2174/0109298673267136231003113803
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  • Article Type:     Research Article
Keyword(s): anti-bacterial activity; cytotoxicity; Mycobacterium tuberculosis; Quinolinylhydrazone; resistant strain; tuberculosis

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