Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Medicinal Chemistry
  4. Volume 31, Issue 41
  5. Article
Volume 31, Issue 41
  • ISSN: 0929-8673
  • E-ISSN: 1875-533X

Abstract

Background

Propolis and its major phenolic compound, caffeic acid phenethyl ester (CAPE), have garnered considerable scientific interest due to their anti-inflammatory properties and potential therapeutic applications.

Objectives

This narrative review explores the potential utility of CAPE in cancer treatment.

Methods

We comprehensively reviewed relevant studies from scientific databases (PubMed and Web of Science) from 2000 to 2022. Our search focused on keywords such as cancer, natural drugs, caffeic acid phenethyl ester, CAPE, cancer cell lines, antitumor effects, and propolis.

Results

CAPE exhibits diverse biological benefits, including antimicrobial, antioxidant, antiviral, anti-inflammatory, cytotoxic, and potentially anti-carcinogenic properties. Numerous studies have demonstrated its wide-ranging antitumor effects on various cancer cell lines, including growth inhibition, apoptosis induction, tumor invasiveness prevention, malignancy suppression, and anti-angiogenic activity.

Conclusion

Following comprehensive preclinical toxicity assessments, further evaluation of CAPE's efficacy and safety through clinical trials is highly recommended to elucidate its potential health benefits in diverse forms of human cancer.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cmc/10.2174/0109298673252993230921073502
2023-11-06
2024-11-20

  • From This Site

    /content/journals/cmc/10.2174/0109298673252993230921073502
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. DurazzoA. LucariniM. SoutoE.B. CicalaC. CaiazzoE. IzzoA.A. NovellinoE. SantiniA. Polyphenols: A concise overview on the chemistry, occurrence, and human health.Phytother. Res.20193392221224310.1002/ptr.641931359516
     [Google Scholar]
  2. MajidiniaM. BishayeeA. YousefiB. Polyphenols: Major regulators of key components of DNA damage response in cancer.DNA Repair (Amst.)20198210267910.1016/j.dnarep.2019.10267931450085
     [Google Scholar]
  3. BułdakR.J. HejmoT. OsowskiM. BułdakŁ. KuklaM. PolaniakR. BirknerE. The impact of coffee and its selected bioactive compounds on the development and progression of colorectal cancer in vivo and in vitro.Molecules20182312330910.3390/molecules2312330930551667
     [Google Scholar]
  4. EspíndolaK.M.M. FerreiraR.G. NarvaezL.E.M. Silva RosarioA.C.R. da SilvaA.H.M. SilvaA.G.B. VieiraA.P.O. MonteiroM.C. Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma.Front. Oncol.2019954110.3389/fonc.2019.0054131293975
     [Google Scholar]
  5. Kabała-DzikA. Rzepecka-StojkoA. KubinaR. Jastrzębska-StojkoŻ. StojkoR. WojtyczkaR. StojkoJ. Comparison of two components of propolis: Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231.Molecules2017229155410.3390/molecules2209155428926932
     [Google Scholar]
  6. KuoC.C. WangR.H. WangH.H. LiC.H. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis.Support. Care Cancer201826124001400910.1007/s00520‑018‑4344‑530022350
     [Google Scholar]
  7. WaheedM. HussainM.B. JavedA. MushtaqZ. HassanS. ShariatiM.A. KhanM.U. MajeedM. NigamM. MishraA.P. HeydariM. Honey and cancer: A mechanistic review.Clin. Nutr.20193862499250310.1016/j.clnu.2018.12.01930639116
     [Google Scholar]
  8. ZabaiouN. FouacheA. TroussonA. BaronS. ZellaguiA. LahouelM. LobaccaroJ.A. Biological properties of propolis extracts: Something new from an ancient product.Chem Phys Lipids.2017207Pt B21422210.1016/j.chemphyslip.2017.04.005
     [Google Scholar]
  9. AlamM. AhmedS. ElasbaliA.M. AdnanM. AlamS. HassanM.I. PasupuletiV.R. Therapeutic implications of caffeic acid in cancer and neurological diseases.Front. Oncol.20221286050810.3389/fonc.2022.86050835359383
     [Google Scholar]
  10. MirzaeiS. GholamiM.H. ZabolianA. SalekiH. FarahaniM.V. HamzehlouS. FarF.B. SharifzadehS.O. SamarghandianS. KhanH. ArefA.R. AshrafizadehM. ZarrabiA. SethiG. Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer.Pharmacol. Res.202117110575910.1016/j.phrs.2021.10575934245864
     [Google Scholar]
  11. StohsS.J. Safety and efficacy of shilajit (mumie, moomiyo).Phytother. Res.201428447547910.1002/ptr.501823733436
     [Google Scholar]
  12. BoisardS. ShahaliY. AumondM.C. DerbréS. BlanchardP. DadarM. Le RayA.M. RichommeP. Anti-AGE activity of poplar-type propolis: Mechanism of action of main phenolic compounds.Int. J. Food Sci. Technol.201910.1111/ijfs.14284
     [Google Scholar]
  13. MainasaraM.M. Abu BakarM.F. C LinatocA.A. Malaysian medicinal plants’ potential for breast cancer therapy.Asian J. Pharm. Clin. Res.201811610111710.22159/ajpcr.2018.v11i6.24322
     [Google Scholar]
  14. BjørklundG. DadarM. ChirumboloS. LysiukR. Flavonoids as detoxifying and pro-survival agents: What’s new?Food Chem. Toxicol.201711024025010.1016/j.fct.2017.10.03929079495
     [Google Scholar]
  15. ChirumboloS. BjørklundG. LysiukR. VellaA. LenchykL. UpyrT. Targeting cancer with phytochemicals via their fine tuning of the cell survival signaling pathways.Int. J. Mol. Sci.20181911356810.3390/ijms1911356830424557
     [Google Scholar]
  16. LysiukR. HudzN. Differential spectrophotometry: Application for quantification of flavonoids in herbal drugs and nutraceuticals. Int. J Trends.Food Nutr. (Roma)20171e102
     [Google Scholar]
  17. TolbaM.F. AzabS.S. KhalifaA.E. Abdel-RahmanS.Z. Abdel-NaimA.B. Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects.IUBMB Life201365869970910.1002/iub.118923847089
     [Google Scholar]
  18. AkyolS. OzturkG. GinisZ. ArmutcuF. YigitogluM.R. AkyolO. In vivo and in vitro antıneoplastic actions of caffeic acid phenethyl ester (CAPE): Therapeutic perspectives.Nutr. Cancer201365451552610.1080/01635581.2013.77669323659443
     [Google Scholar]
  19. MurtazaG. KarimS. AkramM.R. KhanS.A. AzharS. MumtazA. Bin AsadM.H.H. HassanM.H. Caffeic acid phenethyl ester and therapeutic potentials.BioMed Res. Int.201420141910.1155/2014/14534224971312
     [Google Scholar]
  20. MurtazaG. SajjadA. MehmoodZ. ShahS.H. SiddiqiA.R. Possible molecular targets for therapeutic applications of caffeic acid phenethyl ester in inflammation and cancer.J. Food Drug Anal.2015231111810.1016/j.jfda.2014.06.00128911433
     [Google Scholar]
  21. NaveedM. HejaziV. AbbasM. KambohA.A. KhanG.J. ShumzaidM. AhmadF. BabazadehD. FangFangX. Modarresi-GhazaniF. WenHuaL. XiaoHuiZ. Chlorogenic acid (CGA): A pharmacological review and call for further research.Biomed. Pharmacother.201897677410.1016/j.biopha.2017.10.06429080460
     [Google Scholar]
  22. KoshovyiO. ZagaykoA. KolychevI. AkhmedovE.Y. KomissarenkoA. Phytochemical study of the dry extract from bilberry leaves.Azerbaijan Pharm. Pharmacother. J.201611823
     [Google Scholar]
  23. ShinkovenkoI.L. KashpurN.V. IlyinaT.V. KovalyovaA.M. GoryachaO.V. KoshovyiO.M. ToryanykE.L. KryvoruchkoO.V. The immunomodulatory activity of the extracts and complexes of biologically active compounds of Galium verum L. herb.Ceska Slov. Farm.2018671252930157664
     [Google Scholar]
  24. JiangY. LinY. HuY.J. SongX.J. PanH.H. ZhangH.J. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model.BMC Complement. Altern. Med.201717132010.1186/s12906‑017‑1834‑928623927
     [Google Scholar]
  25. LeeY.J. JangY.N. HanY.M. KimH.M. JeongJ.M. SonM.J. JinC.B. KimH.J. SeoH.S. Caffeoylquinic acid-rich extract of Aster glehni F. Schmidt ameliorates nonalcoholic fatty liver through the regulation of PPARdelta and adiponectin in ApoE KO mice.PPAR Res.2017201711910.1155/2017/391256729201040
     [Google Scholar]
  26. LenchykL. OvezgeldiyevD. UpyrD. Phytochemical investigation of bird cherry fruits.Pharm. Lett.2016867376
     [Google Scholar]
  27. LenchykL.V. SaidovN.B. Investigation of phenolic compounds in cherry leaves extract.Res. J. Pharm. and Tech.201710124402440610.5958/0974‑360X.2017.00811.3
     [Google Scholar]
  28. MortonL.W. CaccettaR.A-A. PuddeyI.B. CroftK.D. Chemistry and biological effects of dietary phenolic compounds: Relevance to cardiovascular disease.Clin. Exp. Pharmacol. Physiol.200027315215910.1046/j.1440‑1681.2000.03214.x10744340
     [Google Scholar]
  29. KanimozhiG. PrasadN.R. Coffee in Health and Disease Prevention. VrP. AmsterdamAcademic Press201565566110.1016/B978‑0‑12‑409517‑5.00073‑5
     [Google Scholar]
  30. PopovaM. ReyesM. Le ConteY. BankovaV. Propolis chemical composition and honeybee resistance against Varroa destructor.Nat. Prod. Res.2014281178879410.1080/14786419.2014.88136624483289
     [Google Scholar]
  31. BankovaV. TrushevaB. PopovaM. Caffeic acid phenethyl ester (CAPE)-natural sources, analytical procedures and synthetic approaches.Dokl. Bulg. Akad. Nauk.20187191157116910.7546/CRABS.2018.09.01
     [Google Scholar]
  32. KečkešS. GašićU. VeličkovićT.Ć. Milojković-OpsenicaD. NatićM. TešićŽ. The determination of phenolic profiles of Serbian unifloral honeys using ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry.Food Chem.20131381324010.1016/j.foodchem.2012.10.02523265452
     [Google Scholar]
  33. WuJ. OmeneC. KarkoszkaJ. BoslandM. EckardJ. KleinC.B. FrenkelK. Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer.Cancer Lett.20113081435310.1016/j.canlet.2011.04.01221570765
     [Google Scholar]
  34. ChenH.C. ChenJ.H. ChangC. ShiehC.J. Optimization of ultrasound-accelerated synthesis of enzymatic caffeic acid phenethyl ester by response surface methodology.Ultrason. Sonochem.201118145545910.1016/j.ultsonch.2010.07.01820797894
     [Google Scholar]
  35. KimH. ParkC. Enzymatic synthesis of phenethyl ester from phenethyl alcohol with acyl donors.Enzyme Microb. Technol.2017100374410.1016/j.enzmictec.2017.02.00428284310
     [Google Scholar]
  36. WangX. PangJ. MaffucciJ.A. PadeD.S. NewmanR.A. KerwinS.M. BowmanP.D. StavchanskyS. Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats.Biopharm. Drug Dispos.200930522122810.1002/bdd.65719544289
     [Google Scholar]
  37. KleczkaA. KubinaR. DzikR. JasikK. StojkoJ. CholewaK. Kabała-DzikA. Caffeic acid phenethyl ester (CAPE) induced apoptosis in serous ovarian cancer OV7 cells by deregulation of BCL2/BAX genes.Molecules20202515351410.3390/molecules2515351432752091
     [Google Scholar]
  38. Rzepecka-StojkoA. Kabała-DzikA. MoździerzA. KubinaR. WojtyczkaR. StojkoR. DziedzicA. Jastrzębska-StojkoŻ. JurzakM. BuszmanE. StojkoJ. Caffeic acid phenethyl ester and ethanol extract of propolis induce the complementary cytotoxic effect on triple-negative breast cancer cell lines.Molecules20152059242926210.3390/molecules2005924226007182
     [Google Scholar]
  39. ChengC.C. ChiP.L. ShenM.C. ShuC.W. WannS.R. LiuC.P. TsengC.J. HuangW.C. Caffeic acid phenethyl ester rescues pulmonary arterial hypertension through the inhibition of AKT/ERK-dependent PDGF/HIF-1α in vitro and in vivo.Int. J. Mol. Sci.2019206146810.3390/ijms2006146830909527
     [Google Scholar]
  40. YordanovY. Caffeic acid phenethyl ester (CAPE): Pharmacodynamics and potential for therapeutic application.Pharmacia201966310711410.3897/pharmacia.66.e38573
     [Google Scholar]
  41. ShenH. YamashitaA. NakakoshiM. YokoeH. SudoM. KasaiH. TanakaT. FujimotoY. IkedaM. KatoN. SakamotoN. ShindoH. MaekawaS. EnomotoN. TsubukiM. MoriishiK. Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus.PLoS One2013812e8229910.1371/journal.pone.008229924358168
     [Google Scholar]
  42. LinH.P. LinC.Y. HuoC. HsiaoP.H. SuL.C. JiangS.S. ChanT.M. ChangC.H. ChenL.T. KungH.J. WangH.D. ChuuC.P. Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.Oncotarget2015696684670710.18632/oncotarget.324625788262
     [Google Scholar]
  43. LinH.P. LinC.Y. LiuC.C. SuL.C. HuoC. KuoY.Y. TsengJ.C. HsuJ.M. ChenC.K. ChuuC.P. Caffeic acid phenethyl ester as a potential treatment for advanced prostate cancer targeting akt signaling.Int. J. Mol. Sci.20131435264528310.3390/ijms1403526423466879
     [Google Scholar]
  44. MotawiT.K. AbdelazimS.A. DarwishH.A. ElbazE.M. ShoumanS.A. Could caffeic acid phenethyl ester expand the antitumor effect of tamoxifen in breast carcinoma?Nutr. Cancer201668343544510.1080/01635581.2016.115366927007181
     [Google Scholar]
  45. D’AlmeidaR.E. AlbertoM.R. QuispeC. Schmeda-HirschmannG. IslaM.I. Antimicrobial phenylpropanoids from the Argentinean highland plant Parastrephia lucida (Meyen) Cabrera.J. Ethnopharmacol.2012142240741410.1016/j.jep.2012.05.01022735664
     [Google Scholar]
  46. JungW.K. LeeD.Y. KimJ.H. ChoiI. ParkS.G. SeoS.K. LeeS.W. LeeC.M. ParkY.M. JeonY.J. LeeC.H. JeonB-T. QianZ-J. KimS-K. ChoiI-W. Anti-inflammatory activity of caffeic acid phenethyl ester (CAPE) extracted from Rhodiola sacra against lipopolysaccharide-induced inflammatory responses in mice.Process Biochem.200843778378710.1016/j.procbio.2008.03.004
     [Google Scholar]
  47. RussoA. LongoR. VanellaA. Antioxidant activity of propolis: Role of caffeic acid phenethyl ester and galangin.Fitoterapia200273Suppl. 1S21S2910.1016/S0367‑326X(02)00187‑912495706
     [Google Scholar]
  48. IrazM. OzerolE. GulecM. TasdemirS. IdizN. FadilliogluE. NazirogluM. AkyolO. Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat.Cell Biochem. Funct.200624435736110.1002/cbf.123216437419
     [Google Scholar]
  49. NurG. HusunetM. GulerI. DeveciA. KocE. NurO. KilicleP. The effect of caffeic acid phenethyl ester (CAPE) on hepatic histopathology and oxidative stress in rats treated with malathion.Med. Sci. (Turkey)20187060460910.5455/medscience.2018.07.8833
     [Google Scholar]
  50. ReuterS. GuptaS.C. ChaturvediM.M. AggarwalB.B. Oxidative stress, inflammation, and cancer: How are they linked?Free Radic. Biol. Med.201049111603161610.1016/j.freeradbiomed.2010.09.00620840865
     [Google Scholar]
  51. BilikovaK. PopovaM. TrushevaB. BankovaV. New anti-Paenibacillus larvae substances purified from propolis.Apidologie (Celle)201344327828510.1007/s13592‑012‑0178‑1
     [Google Scholar]
  52. KooH.J. LeeK.R. KimH.S. LeeB.M. Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers.Food Chem. Toxicol.20191309910810.1016/j.fct.2019.05.02931112706
     [Google Scholar]
  53. IshikawaH. GotoM. MatsuuraN. MurakamiY. GotoC. SakaiT. KanazawaK. A pilot, randomized, placebo-controlled, double-blind phase 0/biomarker study on effect of artepillin C-rich extract of Brazilian propolis in frequent colorectal adenoma polyp patients.J. Am. Coll. Nutr.201231532733710.1080/07315724.2012.1072043423529990
     [Google Scholar]
  54. AltuğM.E. SerarslanY. BalR. KontaşT. EkiciF. MelekI.M. AslanH. DumanT. Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: A biochemical and planimetric study.Brain Res.2008120113514210.1016/j.brainres.2008.01.05318308295
     [Google Scholar]
  55. OzerM.K. ParlakpinarH. AcetA. Reduction of ischemia–reperfusion induced myocardial infarct size in rats by caffeic acid phenethyl ester (CAPE).Clin. Biochem.200437870270510.1016/j.clinbiochem.2004.01.01215302615
     [Google Scholar]
  56. AmaliaE. DiantiniA. Endang PrabandariE. WaluyoD. SubarnasA. Caffeic acid phenethyl ester as a DHODH inhibitor and its synergistic anticancer properties in combination with 5-fluorouracil in a breast cancer cell line.J. Exp. Pharmacol.20221424325310.2147/JEP.S36515935910085
     [Google Scholar]
  57. FuY.K. WangB.J. TsengJ.C. HuangS.H. LinC.Y. KuoY.Y. HourT.C. ChuuC.P. Combination treatment of docetaxel with caffeic acid phenethyl ester suppresses the survival and the proliferation of docetaxel-resistant prostate cancer cells via induction of apoptosis and metabolism interference.J. Biomed. Sci.20222911610.1186/s12929‑022‑00797‑z35197069
     [Google Scholar]
  58. ChangK.S. TsuiK.H. HsuS.Y. SungH.C. LinY.H. HouC.P. YangP.S. ChenC.L. FengT.H. JuangH.H. The antitumor effect of caffeic acid phenethyl ester by downregulating mucosa-associated lymphoid tissue 1 via ar/p53/nf-kappab signaling in prostate carcinoma cells.Cancers (Basel)202214227410.3390/cancers1402027435053438
     [Google Scholar]
  59. FraserS.P. HemsleyF. DjamgozM.B.A. Caffeic acid phenethyl ester: Inhibition of metastatic cell behaviours via voltage-gated sodium channel in human breast cancer in vitro.Int. J. Biochem. Cell Biol.20167111111810.1016/j.biocel.2015.12.01226724521
     [Google Scholar]
  60. DemestreM. MesserliS.M. CelliN. ShahhossiniM. KluweL. MautnerV. MarutaH. CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.Phytother. Res.200923222623010.1002/ptr.259418726924
     [Google Scholar]
  61. OzturkG. GinisZ. AkyolS. ErdenG. GurelA. AkyolO. The anticancer mechanism of caffeic acid phenethyl ester (CAPE): Review of melanomas, lung and prostate cancers.Eur. Rev. Med. Pharmacol. Sci.201216152064206823280020
     [Google Scholar]
  62. JiangX. XieH. LiC. YouM. ZhengY. LiG.Q. ChenX. ZhangC. HuF. Chinese propolis inhibits the proliferation of human gastric cancer cells by inducing apoptosis and cell cycle arrest.Evid. Based Complement. Alternat. Med.2020202011110.1155/2020/274305832774408
     [Google Scholar]
  63. AkyolS. GinisZ. ArmutcuF. OzturkG. YigitogluM.R. AkyolO. The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity.Cell Biochem. Funct.201230543844310.1002/cbf.281722431158
     [Google Scholar]
  64. CauliO. Oxidative stress and cognitive alterations induced by cancer chemotherapy drugs: A scoping review.Antioxidants2021107111610.3390/antiox1007111634356349
     [Google Scholar]
  65. LuoC. XuX. WeiX. FengW. HuangH. LiuH. XuR. LinJ. HanL. ZhangD. Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms.Pharmacol. Res.201914810440910.1016/j.phrs.2019.10440931446039
     [Google Scholar]
  66. SungH.C. ChangK.S. ChenS.T. HsuS.Y. LinY.H. HouC.P. FengT.H. TsuiK.H. JuangH.H. Metallothionein 2A with antioxidant and antitumor activity is upregulated by caffeic acid phenethyl ester in human bladder carcinoma cells.Antioxidants2022118150910.3390/antiox1108150936009228
     [Google Scholar]
  67. GongZ. GaoX. YangQ. LunJ. XiaoH. ZhongJ. CaoH. Phosphorylation of ERK-dependent NF-κB triggers NLRP3 inflammasome mediated by vimentin in EV71-infected glioblastoma cells.Molecules20222713419010.3390/molecules2713419035807435
     [Google Scholar]
  68. SucuB.O. KocE.B. Savlug IpekO. MiratA. AlmasF. GuzelM.A. DoganB. UludagD. KarakasN. DurdagiS. GuzelM. Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines.J. Mol. Graph. Model.202211310816010.1016/j.jmgm.2022.10816035248814
     [Google Scholar]
  69. PireddaM. FacchinettiG. BiagioliV. GiannarelliD. ArmentoG. ToniniG. De MarinisM.G. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial.Eur. J. Cancer Care (Engl.)2017266e1275710.1111/ecc.1275728840622
     [Google Scholar]
  70. SforcinJ.M. Propolis and the immune system: A review.J. Ethnopharmacol.2007113111410.1016/j.jep.2007.05.01217580109
     [Google Scholar]
  71. MarucciL. FarnetiA. Di RidolfiP. PinnaroP. PelliniR. GiannarelliD. ViciP. ConteM. LandoniV. SanguinetiG. Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer.Head Neck20173991761176910.1002/hed.2483228560780
     [Google Scholar]
  72. AkhavanKarbassi Randomized double blind placebo controlled trial of propolis for oral mucositis in patients receiving chemotherapy for head and neck cancer.Asian Pac. J. Cancer Prev.20161773611361427510017
     [Google Scholar]
  73. NoronhaV. AraujoG. GomesR. IwanagaS. BarbosaM. AbdoE. e FerreiraE. VianaA. SouzaA. AbreuS. SantosV. Mucoadhesive propolis gel for prevention of radiation-induced oral mucositis.Curr. Clin. Pharmacol.20149435936410.2174/157488470966614020521005124502424
     [Google Scholar]
  74. AbdulrhmanM. Samir ElbarbaryN. Ahmed AminD. Saeid EbrahimR. Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: A randomized controlled pilot study.Pediatr. Hematol. Oncol.201229328529210.3109/08880018.2012.66902622475306
     [Google Scholar]
  75. TomaževičT. JazbecJ. A double blind randomised placebo controlled study of propolis (bee glue) effectiveness in the treatment of severe oral mucositis in chemotherapy treated children.Complement. Ther. Med.201321430631210.1016/j.ctim.2013.04.00223876561
     [Google Scholar]
  76. ShinS.H. LeeS.R. LeeE. KimK.H. ByunS. Caffeic acid phenethyl ester from the twigs of Cinnamomum cassia inhibits malignant cell transformation by inducing c-Fos degradation.J. Nat. Prod.20178072124213010.1021/acs.jnatprod.7b0043328682072
     [Google Scholar]
  77. ErdisE. Can CAPE be used as ideal antitumor agent “safely”?Eur. Rev. Med. Pharmacol. Sci.201317456723467961
     [Google Scholar]
  78. OmeneC. KalacM. WuJ. MarchiE. FrenkelK. O’ConnorO.A. Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action.J. Cancer Sci. Ther.201351033434224466386
     [Google Scholar]
  79. OmeneC.O. WuJ. FrenkelK. Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells.Invest. New Drugs20123041279128810.1007/s10637‑011‑9667‑821537887
     [Google Scholar]
  80. KosovaF. KurtF.O. OlmezE. TuğluI. ArıZ. Effects of caffeic acid phenethyl ester on matrix molecules and angiogenetic and anti-angiogenetic factors in gastric cancer cells cultured on different substrates.Biotech. Histochem.2016911384710.3109/10520295.2015.107276926523612
     [Google Scholar]
  81. KimH.G. HanE.H. ImJ.H. LeeE.J. JinS.W. JeongH.G. Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1α.Biochem. Biophys. Res. Commun.2015465356256810.1016/j.bbrc.2015.08.06026296470
     [Google Scholar]
  82. KuoY.Y. JimW.T. SuL.C. ChungC.J. LinC.Y. HuoC. TsengJ.C. HuangS.H. LaiC.J. ChenB.C. WangB.J. ChanT.M. LinH.P. ChangW.S. ChangC.R. ChuuC.P. Caffeic acid phenethyl ester is a potential therapeutic agent for oral cancer.Int. J. Mol. Sci.20151612107481076610.3390/ijms16051074825984601
     [Google Scholar]
  83. BalkhiH.M. GulT. SanaS. HaqE. Potential synergism of caffeic acid phenethyl ester and dasatinib in c6 glioma cell model: Adumbrating the molecular mechanism.Brain Disord. Ther.201872210.4172/2168‑975X.1000245
     [Google Scholar]
  84. BudisanL. GuleiD. JurjA. BraicuC. ZanoagaO. CojocneanuR. PopL. RadulyL. BarbatA. MoldovanA. MoldovanC. TiguA. IonescuC. AtanasovA. IrimieA. Berindan-NeagoeI. Inhibitory effect of cape and kaempferol in colon cancer cell lines—possible implications in new therapeutic strategies.Int. J. Mol. Sci.2019205119910.3390/ijms2005119930857282
     [Google Scholar]
  85. ChungL.C. ChiangK.C. FengT.H. ChangK.S. ChuangS.T. ChenY.J. TsuiK.H. LeeJ.C. JuangH.H. Caffeic acid phenethyl ester upregulates N-myc downstream regulated gene 1 via ERK pathway to inhibit human oral cancer cell growth in vitro and in vivo.Mol. Nutr. Food Res.2017619160084210.1002/mnfr.20160084228181403
     [Google Scholar]
  86. DziedzicA. KubinaR. Kabała-DzikA. TanasiewiczM. Induction of cell cycle arrest and apoptotic response of head and neck squamous carcinoma cells (Detroit 562) by caffeic acid and caffeic acid phenethyl ester derivative.Evid. Based Complement. Alternat. Med.2017201711010.1155/2017/679345628167973
     [Google Scholar]
  87. ChangH. WangY. YinX. LiuX. XuanH. Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy.BMC Complement. Altern. Med.201717147110.1186/s12906‑017‑1984‑928950845
     [Google Scholar]
  88. ImaiM. YokoeH. TsubukiM. TakahashiN. Growth inhibition of human breast and prostate cancer cells by cinnamic acid derivatives and their mechanism of action.Biol. Pharm. Bull.20194271134113910.1248/bpb.b18‑0100230982786
     [Google Scholar]
  89. Kabała-DzikA. Rzepecka-StojkoA. KubinaR. WojtyczkaR.D. BuszmanE. StojkoJ. Caffeic acid versus caffeic acid phenethyl ester in the treatment of breast cancer MCF-7 cells: Migration rate inhibition.Integr. Cancer Ther.20181741247125910.1177/153473541880152130246565
     [Google Scholar]
  90. ChiangK.C. YangS.W. ChangK.P. FengT.H. ChangK.S. TsuiK.H. ShinY.S. ChenC.C. ChaoM. JuangH.H. Caffeic acid phenethyl ester induces N-myc downstream regulated gene 1 to inhibit cell proliferation and invasion of human nasopharyngeal cancer cells.Int. J. Mol. Sci.2018195139710.3390/ijms1905139729738439
     [Google Scholar]
  91. LiangY. FengG. WuL. ZhongS. GaoX. TongY. CuiW. QinY. XuW. XiaoX. ZhangZ. HuangG. ZhouX. Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway.Drug Des. Devel. Ther.2019131335134510.2147/DDDT.S19918231118570
     [Google Scholar]
  92. LiuG.L. HanN.Z. LiuS.S. Caffeic acid phenethyl ester inhibits the progression of ovarian cancer by regulating NF-κB signaling.Biomed. Pharmacother.20189982583110.1016/j.biopha.2018.01.12929710481
     [Google Scholar]
  93. KhoramN.M. BigdeliB. NikoofarA. GoliaeiB. Caffeic acid phenethyl ester increases radiosensitivity of estrogen receptor-positive and-negative breast cancer cells by prolonging radiation-induced DNA damage.J. Breast Cancer2016191182510.4048/jbc.2016.19.1.1827066092
     [Google Scholar]
  94. OmeneC. PatelM. KaragozK. GatzaM.L. Barcellos-HoffM.H. Abstract P4-07-03: Immunomodulation of triple negative breast cancer by caffeic acid phenethyl ester (CAPE).Cancer Res.2019794_SupplementP4-07-0310.1158/1538‑7445.SABCS18‑P4‑07‑03
     [Google Scholar]
  95. OnoriP. DeMorrowS. GaudioE. FranchittoA. MancinelliR. VenterJ. KoprivaS. UenoY. AlvaroD. SavageJ. AlpiniG. FrancisH. Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-κB and induction of apoptosis.Int. J. Cancer2009125356557610.1002/ijc.2427119358267
     [Google Scholar]
  96. FıratF. ÖzgülM. Türköz UluerE. InanS. Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines.Biotech. Histochem.201994749149710.1080/10520295.2019.158957430991851
     [Google Scholar]
  97. KurauchiY. HisatsuneA. IsohamaY. MishimaS. KatsukiH. Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor.Br. J. Pharmacol.201216631151116810.1111/j.1476‑5381.2012.01833.x22224485
     [Google Scholar]
  98. WadhwaR. NigamN. BhargavaP. DhanjalJ.K. GoyalS. GroverA. SundarD. IshidaY. TeraoK. KaulS.C. Molecular characterization and enhancement of anticancer activity of caffeic acid phenethyl ester by γ cyclodextrin.J. Cancer20167131755177110.7150/jca.1517027698914
     [Google Scholar]
  99. WuW. GaoF. SongX.H.F. ZhaoY. XuM. ZhangX. YangZ. YangZ. Caffeic Acid Phenethyl Ester (CAPE) mediated decrease in metastasis of colon cancer cells: An in vitro and in vivo study.Afr. J. Tradit. Complement. Altern. Med.2017145637110.21010/ajtcam.v14i5.9
     [Google Scholar]
  100. IshidaY. GaoR. ShahN. BhargavaP. FuruneT. KaulS.C. TeraoK. WadhwaR. Anticancer activity in honeybee propolis: Functional insights to the role of caffeic acid phenethyl ester and its complex with γ-cyclodextrin.Integr. Cancer Ther.201817386787310.1177/153473541775354529390900
     [Google Scholar]
  101. PattingreS. LevineB. Bcl-2 inhibition of autophagy: A new route to cancer?Cancer Res.20066662885288810.1158/0008‑5472.CAN‑05‑441216540632
     [Google Scholar]
  102. GongC. BauvyC. TonelliG. YueW. DeloménieC. NicolasV. ZhuY. DomergueV. Marin-EstebanV. TharingerH. DelbosL. Gary-GouyH. MorelA-P. GhavamiS. SongE. CodognoP. MehrpourM. Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells.Oncogene2013321822612272, 1-1110.1038/onc.2012.25222733132
     [Google Scholar]
  103. GongC. SongE. CodognoP. MehrpourM. The roles of BECN1 and autophagy in cancer are context dependent.Autophagy20128121853185510.4161/auto.2199622960473
     [Google Scholar]
  104. HuiB. ShiY.H. DingZ.B. ZhouJ. GuC.Y. PengY.F. YangH. LiuW.R. ShiG.M. FanJ. Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma.Cancer2012118225560557110.1002/cncr.2758622517429
     [Google Scholar]
  105. HeY.J. LiW-L. LiuB-H. DongH. MouZ-R. WuY-Z. Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.World J. Gastroenterol.20142033118401184910.3748/wjg.v20.i33.1184025206290
     [Google Scholar]
  106. GavilánE. GiráldezS. Sánchez-AguayoI. RomeroF. RuanoD. DazaP. Breast cancer cell line MCF7 escapes from G1/S arrest induced by proteasome inhibition through a GSK-3β dependent mechanism.Sci. Rep.2015511002710.1038/srep1002725941117
     [Google Scholar]
  107. Francielli de OliveiraP. LimaI.M.S. Monteiro NetoM.A.B. BastosJ.K. da Silva FilhoA.A. TavaresD.C. Evaluation of genotoxicity and antigenotoxicity of artepillin C in V79 cells by the comet and micronucleus assays.Nutr. Cancer20136571098110310.1080/01635581.2013.81523323915392
     [Google Scholar]
  108. MaistroE.L. AngeliJ.P.F. AndradeS.F. MantovaniM.S. In vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids.Genet. Mol. Res.20111021130114010.4238/vol10‑2gmr127821710465
     [Google Scholar]
  109. TanK.W. LiY. PaxtonJ.W. BirchN.P. ScheepensA. Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2).Food Chem.201313842267227410.1016/j.foodchem.2012.12.02123497885
     [Google Scholar]
  110. GaoM. ZhangW. LiuQ. HuJ. LiuG. DuG. Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio.Eur. J. Pharmacol.20085911-3737910.1016/j.ejphar.2008.06.07118625218
     [Google Scholar]
  111. BorrelliF. IzzoA.A. Di CarloG. MaffiaP. RussoA. MaielloF.M. CapassoF. MascoloN. Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon.Fitoterapia200273Suppl. 1S38S4310.1016/S0367‑326X(02)00189‑212495708
     [Google Scholar]
  112. DavoodiS.H. YousefinejadV. GhaderiB. AkbariM.E. DarvishiS. MehrabiY. DarvishiN. Oral propolis, nutritional status and quality of life with chemotherapy for breast cancer: A randomized, double-blind clinical trial.Nutr. Cancer20227462029203710.1080/01635581.2021.198811834622721
     [Google Scholar]
/content/journals/cmc/10.2174/0109298673252993230921073502
Loading
Caffeic Acid Phenethyl Ester: A Potential Therapeutic Cancer Agent?
Curr. Med. Chem. 31, 6760 (2024); https://doi.org/10.2174/0109298673252993230921073502
/content/journals/cmc/10.2174/0109298673252993230921073502
/content/journals/cmc/10.2174/0109298673252993230921073502
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): antitumor effects; caffeic acid phenethyl ester; Cancer; cancer cell lines; natural drugs; propolis

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test